DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and Nphs1

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_072150.1 Gene:Nphs1 / 64563 RGDID:620460 Length:1252 Species:Rattus norvegicus


Alignment Length:1294 Identity:367/1294 - (28%)
Similarity:580/1294 - (44%) Gaps:160/1294 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HWIKHLQLLRLLAVIV--LASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTK 106
            |....|..|.|:.::.  ||.:|||:.| .|.|.....:|..:||....:.|.|......|||.|
  Rat    17 HRTSSLTPLLLMGMLTSGLAESPVPTSA-PQGFWALSENLTAVEGTTVKLWCGVRAPGSVVQWAK 80

  Fly   107 DGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNS---------AI 162
            ||..||.:..:|||||||:.|||.:|.::|.|....::|||:|:||||.:.|..         :|
  Rat    81 DGLLLGPNPKMPGFPRYSLEGDRAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPKVILSI 145

  Fly   163 RANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYR---------GNV 218
            ..:.|:.:::|.|         .|.|.....|:..:.|:..:||||..|.:.:         .||
  Rat   146 LVSPKVLLLTPEA---------GSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSSNV 201

  Fly   219 EYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPP 283
            .          |.|..|...|.:..::.|...|:.....|:..:.||  |.|::|:..:::|:||
  Rat   202 N----------EGSEEKLCITEAEARVIPQSSDNGQLLVCEGSNPAL--DTPIKASFTMNILFPP 254

  Fly   284 GPPYIE--GYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRT--SGRLSENIYTF 344
            |||.|:  |.:.|. :|.|:.:||.|.:|||||||.|.|.|||..:..|:.|  :..::.::...
  Rat   255 GPPVIDWPGLNEGH-VRAGENLELPCTARGGNPPATLQWLKNGKPVSTAWGTEHAQAVAHSVLVM 318

  Fly   345 TAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPP 409
            |....|:.||..|::.|.:|....:..:.|.|.|.|:.:|::|.........|.|.|.|..|.|.
  Rat   319 TVRPEDHGARLSCQSYNSVSAGTQERSITLQVTFPPSAITILGSVSQSENKNVTLCCLTKSSRPR 383

  Fly   410 AEIKWMVGGRQVRNATSKTIVSP-EGGWTTTSNITAVVEPNKRSLVVICHGLNMQLT-ENVVSTH 472
            ..::|.:||||:. .|.:|::.. .||..:.||:|.:|......|.:.|...:...: |....:.
  Rat   384 VLLRWWLGGRQLL-PTDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFSDAFSKETFKKSL 447

  Fly   473 TINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRIN------------ 525
            |:||.||.....|.|..|||.|..|:..:|:|::.||||..:|.|:|:.:.::            
  Rat   448 TLNVKYPAQKLWIEGPPEGQYIRTGTRVRLVCLAIGGNPDPSLIWFKDSRPVSEPRQPQEPRRVQ 512

  Fly   526 -SVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEEL 589
             ..:..:..:.|.|:.::....||:|::.|:|..      |..||.|.|.|.|..:.|......|
  Rat   513 LGSVEKSGSTFSRELVLIIGPPDNRAKFSCKAGQ------LSASTQLVVQFPPTNLTILANSSAL 571

  Fly   590 RPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYT 654
            |||....:.|.|.|||||..|||.|:|..:|.:....:...:.|:.::....:.|:...:||..|
  Rat   572 RPGDALNLTCVSISSNPPVNLSWDKEGERLEDVAAKPQSAPFKGSAASRSVFLRVSSRDHGQRVT 636

  Fly   655 CQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTT 719
            |::.:|||:.:.......:|||.|:|:.........||...:.:.:...|||.|..:.||..|..
  Rat   637 CRAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVEQGQVLLPVSVSANPAPEAFNWTFRGYR 701

  Fly   720 IPQDGD--HRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVV 782
            :...|.  |||.: ||:|....:.|.|.|.|.....||:|.|...:.:.|.|..||:::.:...|
  Rat   702 LSPAGGPRHRILS-GGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALRDPTEV 765

  Fly   783 NPGEDAMLSCTVEGKPLTEEHVKWERVG---YDMTVKTSTTFANG-TSYLHIKDAKREDVGNFRC 843
            |.|....:.|||:..|:..|...|||:|   .|:.:......:.| |..|.|:.||....|.::|
  Rat   766 NVGGSVDIVCTVDANPILPEMFSWERLGEEEEDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAYQC 830

  Fly   844 VADNRVDNPTNRDILLIVKFAPEIAK-TP-TLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKD 906
            :.||.|.......:.|:|:|||::.: || |.:.||..:.....|.|||:|.|...|.|  .|..
  Rat   831 IVDNGVAPAARGLVRLVVRFAPQVDQPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTW--TKNG 893

  Fly   907 LPINRTYKYEVEERKIDSLTYESTLIVDKVAPA-DYGAYECVARNELGEAVETVRLEITSQPDPP 970
            :|::.......|.|....:.:.|.|.:..|:.| ||..::|.|.|.||.....::|...|:||||
  Rat   894 VPLDLQDPRYTEHRYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPP 958

  Fly   971 LSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLP-NSHKLTIGGLRMNTLY 1034
            |.|.:::::..:|.|.|.|||||||...:::||...:...:.::|.|| .:...|:.||:.:|.|
  Rat   959 LGLKVVSISPHSVGLEWKPGFDGGLPQRFQIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTRY 1023

  Fly  1035 LFSVMSWNELGQSSYL------------PDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTS 1087
            ...:::.|.||.|...            ||.|..:|....|...|.     |||.....|     
  Rat  1024 RIWLLASNALGDSGLTDKGIQVSVTTPGPDQAPEDTDHQLPTELPP-----GPPRLPLLP----- 1078

  Fly  1088 GMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFG 1152
              :|..||.  :::|.|...:|..|.:|..:||...:    :|.||..|...             
  Rat  1079 --VLFAVGG--LLLLSNASCVGGLLWRRRLRRLAEEI----SEKTEAGSEDR------------- 1122

  Fly  1153 FLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPS--------SYNDTVTGETLSSV--- 1206
             :........|......|.....|........::..::|.        .|:....||.::..   
  Rat  1123 -IRNEYEESQWTGDRDTRSSTVSTAEVDPNYYSMRDFSPQLPPTLEEVLYHQGAEGEDMAFPGHL 1186

  Fly  1207 -SEKSESYSNEGSSQPEYIDEVR---------------------KKAASTYLVEGSDMP 1243
             .|...:|...|:..|.| ||||                     :.||....||.|.:|
  Rat  1187 HDEVERAYGPPGAWGPLY-DEVRMDPYDLRWPEVQCEDPRGIYDQVAADMDAVEASSLP 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352 38/105 (36%)
Ig 76..155 CDD:299845 33/78 (42%)
IG_like 186..279 CDD:214653 23/101 (23%)
Ig 197..279 CDD:299845 20/90 (22%)
IG_like 296..376 CDD:214653 27/81 (33%)
Ig 300..361 CDD:299845 23/62 (37%)
Ig 380..454 CDD:299845 22/74 (30%)
IG_like 490..573 CDD:214653 25/95 (26%)
Ig 501..560 CDD:299845 16/71 (23%)
Ig 584..666 CDD:299845 26/81 (32%)
IG_like 585..666 CDD:214653 26/80 (33%)
I-set 678..767 CDD:254352 26/90 (29%)
IGc2 692..757 CDD:197706 21/66 (32%)
Ig 788..849 CDD:143165 20/64 (31%)
Ig 885..960 CDD:143165 23/75 (31%)
FN3 967..1051 CDD:238020 30/96 (31%)
Nphs1NP_072150.1 Ig 52..128 CDD:299845 32/75 (43%)
IG_like 52..127 CDD:214653 31/74 (42%)
C2-set_2 155..242 CDD:285423 23/107 (21%)
Ig_3 256..335 CDD:290638 29/79 (37%)
IG_like 268..350 CDD:214653 27/82 (33%)
C2-set_2 358..440 CDD:285423 23/82 (28%)
I-set 460..555 CDD:254352 27/100 (27%)
Ig 472..555 CDD:299845 21/88 (24%)
Ig 563..646 CDD:299845 27/82 (33%)
IG_like 670..750 CDD:214653 24/80 (30%)
Ig 676..750 CDD:299845 22/74 (30%)
Ig_3 753..834 CDD:290638 23/80 (29%)
IG_like 762..848 CDD:214653 25/85 (29%)
Ig 848..956 CDD:299845 34/109 (31%)
IG_like 859..949 CDD:214653 27/91 (30%)
FN3 955..1049 CDD:238020 30/93 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1043..1067 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1144 6/44 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337308
Domainoid 1 1.000 62 1.000 Domainoid score I10087
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20974
Inparanoid 1 1.050 493 1.000 Inparanoid score I1348
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 1 1.000 - - FOG0005450
OrthoInspector 1 1.000 - - otm44453
orthoMCL 1 0.900 - - OOG6_107508
Panther 1 1.100 - - LDO PTHR11640
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3304
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.760

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