DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and ROBO3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_071765.2	Gene:	ROBO3 / 64221	HGNCID:	13433	Length:	1386	Species:	Homo sapiens

Alignment Length:	1135	Identity:	232/1135 - (20%)
Similarity:	391/1135 - (34%)	Gaps:	330/1135 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 GLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKL------LCVSSG--------- 508
            |.|..|   ....||   |.||..|.::|...|   |..::.::      |.||.|
Human    32 GFNSSL---AALNHT---LLPPGDPSLNGSRVG---PEDAMPRIVEQPPDLLVSRGEPATLPCRA 87

  Fly   509 -GNPLATLTWYKN---------DKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASN----S 559
             |.|...:.||||         |.|.:.::..:.......|........::..|.|.|.|    :
Human    88 EGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAA 152

  Fly   560 ATEIPLFQSTTLSVHF--APETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGI 622
            |:.....:...|...|  :|..|.:.:       |..|.:.|.....:|...:||.|||..::
Human   153 ASRNASLEVAVLRDDFRQSPGNVVVAV-------GEPAVLECVPPRGHPEPSVSWRKDGARLK-- 208

  Fly   623 NNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSST 687
            ....:..:.||     :..::.|.:.:..:|.|.::|.|.:|.: .|..:.||.||.|:..|.:.
Human   209 EEEGRITIRGG-----KLMMSHTLKSDAGMYVCVASNMAGERES-AAAEVMVLERPSFLRRPVNQ 267

  Fly   688 AVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSA 752
            .| :....:....:.:.:|.| ..:|.|:...:| .|.:.|.:| .||....:..:|.|.|:|.|
Human   268 VV-LADAPVTFLCEVKGDPPP-RLRWRKEDGELP-TGRYEIRSD-HSLWIGHVSAEDEGTYTCVA 328

  Fly   753 SNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKT 817
            .||.|.|..:.::.|.....:.:..::.:..|||.....|..:|.|  ...:.|::.|..:.:..
Human   329 ENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNP--PPAIFWQKEGSQVLLFP 391

  Fly   818 STTF-------ANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLR 875
            |.:.       .:....|:|...:|.|.|.:.|.|.: |........||.:|.|......|.:|:
Human   392 SQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVS-VAGSILAKALLEIKGASLDGLPPVILQ 455

  Fly   876 AASG----TGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYES----TLI 932
            ..:.    .|....||||..|:|:|...|::|.:.|             :.|.|.:::    ||.
Human   456 GPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWL-------------QGDDLQFKTMANGTLY 507

  Fly   933 VDKVAPADYGAYECVARNELGEAVETVRLEITS----QPDPPLSLN----------ILNVTHDTV 983
            :..|...|.|.|.|||::..|||..:..|::..    .||||...:          :..:|.:::
Human   508 IANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSI 572

  Fly   984 TLAWTPG-FDGGLKASYRVR-YRMADREQYKYI-DGLP-NSHKLTIGGLRMNTLYLFSVMSWNEL 1044
            ||.|.|. ..|....||.:. :..|....::.: ||:. .:|  |:.||:.||:|||.|.:....
Human   573 TLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETH--TVSGLQPNTIYLFLVRAVGAW 635

  Fly  1045 GQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIG 1109
            |.|            |..|.|.|..:....|....:.|..|..|:..|.|
Human   636 GLS------------EPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAV--------------- 673

  Fly  1110 CCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFG-FLLVNASLVAWFFVHQRRKKV 1173
                     ||:..:.|.|..|.             :|....| ..||....|:|        :|
Human   674 ---------RLQEPIVLGPRTLQ-------------VSWTVDGPVQLVQGFRVSW--------RV 708

  Fly  1174 AETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVE 1238
            |..  :......:::.:||..:..:.|
Human   709 AGP--EGGSWTMLDLQSPSQQSTVLRG-------------------------------------- 733

  Fly  1239 GSDMPPP-----RYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSP 1298
               :||.     :.|..|                   :...|:.::.:||.          ||..
Human   734 ---LPPGTQIQIKVQAQG-------------------QEGLGAESLSVTRS----------IPEE 766

  Fly  1299 SPAPPPDGSYYNMNSDRYLSY-----PPM---------EYP--------------AALDFTAQPM 1335
            :|:.||.|....:..|...|.     ||:         ||.              :|..:....|
Human   767 APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAM 831

  Fly  1336 PMAHLQP----MTVTSLATNGG------PTL--------------IGNGSVAAVA---------G 1367
             :..|.|    .|:.:.||:.|      |.|              :|.|....:|         .
Human   832 -LRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLA 895

  Fly  1368 GSGTLRRGILRGVVGV------PQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSL 1426
            |||.....:|.|:...      .:.:::|:|::...:|             |.:...|..|:|:.
Human   896 GSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTP-------------AVSFPHSEGLSGAS 947

  Fly  1427 PTATATLPRQPHGILKD----PNRNKQQQQ 1452
            ......|...|:..|.|    |:|:...|:
Human   948 SRPPMGLGPAPYSWLADSWPHPSRSPSAQE 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	21/111 (19%)
		Ig	501..560	CDD:299845	17/87 (20%)
		Ig	584..666	CDD:299845	17/81 (21%)
		IG_like	585..666	CDD:214653	17/80 (21%)
		I-set	678..767	CDD:254352	23/88 (26%)
		IGc2	692..757	CDD:197706	17/64 (27%)
		Ig	788..849	CDD:143165	13/67 (19%)
		Ig	885..960	CDD:143165	24/78 (31%)
		FN3	967..1051	CDD:238020	27/97 (28%)
ROBO3	NP_071765.2	Ig	64..162	CDD:299845	18/97 (19%)
		I-set	64..161	CDD:254352	18/96 (19%)
		I-set	168..249	CDD:254352	20/95 (21%)
		Ig	170..254	CDD:299845	20/98 (20%)
		I-set	258..343	CDD:254352	23/88 (26%)
		Ig	275..343	CDD:299845	19/70 (27%)
		I-set	347..441	CDD:254352	19/96 (20%)
		Ig	361..450	CDD:299845	20/91 (22%)
		I-set	451..531	CDD:254352	26/92 (28%)
		IGc2	465..528	CDD:197706	22/75 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..563		4/21 (19%)
		FN3	556..649	CDD:238020	27/106 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..662		5/22 (23%)
		FN3	680..760	CDD:238020	19/162 (12%)
		FN3	770..863	CDD:238020	19/93 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..989		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910