DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Jam2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001029176.1	Gene:	Jam2 / 619374	RGDID:	1561692	Length:	298	Species:	Rattus norvegicus

Alignment Length:	215	Identity:	58/215 - (26%)
Similarity:	95/215 - (44%)	Gaps:	40/215 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 EATIICDSSSSNPPAKLSWWKDGIPIEGIN----NTSKPGLWGGTVSTLEFRV---NVTQEMNGQ 651
            ||.:.|.:......::|.|.|.|   :|::    ..:..|.:......::|.:   |||:...|:
  Rat    46 EAILACKTPKKTTSSRLEWKKLG---QGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTRHDAGE 107

  Fly   652 VYTCQ--SANEALQRSAHEAVSLDVLYRPKFVPP---PSSTAVGVEGESLQVSLQTR-ANPTPVT 710
             |.|:  :..|..|....:.|.|:||..|. ||.   |:|.   :.|..:::..|.: .||.| .
  Rat   108 -YRCEVSAPTEQGQNLQEDTVMLEVLVAPA-VPSCEVPTSV---MSGSVVELRCQEKEGNPAP-E 166

  Fly   711 YKWTKDGTTI---PQDGDHR-----IFADGGSLNFTRLHRDDAGIYSCSASNSQG-----GATLN 762
            |.|.||||::   |:.|.||     :....|:|.|..:.:.|:|.|.|.|.||.|     |..:.
  Rat   167 YIWFKDGTSLLGNPKGGAHRNSSYTMNTKSGTLQFNMISKMDSGEYYCEARNSVGHRRCPGKRMQ 231

  Fly   763 ITVVVEYGTTIKSVSENIVV 782
            :.|:     .|..:...:||
  Rat   232 VDVL-----NISGIIAAVVV 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	18/80 (23%)
		IG_like	585..666	CDD:214653	18/80 (23%)
		I-set	678..767	CDD:254352	33/105 (31%)
		IGc2	692..757	CDD:197706	25/73 (34%)
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Jam2	NP_001029176.1	IG_like	37..131	CDD:214653	20/88 (23%)
		Ig	47..113	CDD:143165	15/69 (22%)
		IG_like	143..221	CDD:214653	27/81 (33%)
		IGc2	148..221	CDD:197706	25/73 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910