DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and obsl1b

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:XP_021334748.1 Gene:obsl1b / 606585 ZFINID:ZDB-GENE-050809-29 Length:2929 Species:Danio rerio


Alignment Length:1669 Identity:337/1669 - (20%)
Similarity:559/1669 - (33%) Gaps:550/1669 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QQQQHIKWQQHATKRRR-CRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHD---LQVL 84
            |||..:..|...|.|:. .....:||..:....||..|.:..|...|....|...|.|   ..::
Zfish  1526 QQQSGLDIQSEGTMRKMIIHSAELKHSGVYSCEAVDDLIAFKVDVAAPPVTFAYIPEDDLHRNIV 1590

  Fly    85 EGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADY 149
            |....::.|:|:......||.|||..|..::        :||.:.:..|..|.|.:|.::|...|
Zfish  1591 EQDNILLHCQVSRSDATAQWYKDGVELKSTS--------NVLIEVENDIRRLIILSAHLSDSGTY 1647

  Fly   150 QCQVGPARLNSAIRANAK---LTVISPPASIEIKGY------------SHNSKV-------EVRE 192
            .|:.|.:.|  ..:.|.:   :.::.|...:.:..:            ..|.||       :::|
Zfish  1648 TCRAGDSAL--VFKVNVREPPVMIVYPKEDVHLDRHVPEEIVLSCELSRPNGKVTWFKDGQKLQE 1710

  Fly   193 NQDLQLK----------------------CIVAN------------------------------- 204
            :::::||                      |..|:                               
Zfish  1711 SENIKLKTEGPYRRLKILHSGIEDSGEYVCDTADDSIFFNLNIKEPPVRIVSPSQSQMELCQQTS 1775

  Fly   205 ---------AKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLK----------PGPD 250
                     ::|.|.:.|||..:|         ||||        .||.|:          |.|.
Zfish  1776 ERMVLSCEISRPNATVRWYRDGLE---------VEES--------DSLILEVDGVYRRLIIPKPT 1823

  Fly   251 -DDYTEYTCQARHKALSPDMPMRATVQLSVLYPPG---PPYIEGYSAGETLRRGQTVEL---MCR 308
             .|..||.|.....::        |..:::..||.   .|....|...:.:  |:.|.|   :||
Zfish  1824 VKDSAEYVCDTTDDSV--------TFFVNIAEPPVRFIRPRKMAYGVEKLV--GEIVVLECEVCR 1878

  Fly   309 SRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNK------------ARFRCEA-S 360
                 |.|::.|.|:|.:|          .||......|.|.|:            .::.|:| .
Zfish  1879 -----PNAEVSWKKDGDEI----------EENSNVTITEDGTNRQLTIHSADFEDAGQYVCDARD 1928

  Fly   361 NVM------SQNPL----KAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWM 415
            :||      ...||    ||::|....|             .|.|.:.|.|..:.:|  ..:.|:
Zfish  1929 DVMDFLVKIKDPPLKILRKADIETKRQF-------------MVSDAIVLKCEISRAN--GVVNWL 1978

  Fly   416 VGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTEN-----------VV 469
            ....::           :|    ..:.|...|...|||:|    ||.:|.::           ||
Zfish  1979 KDNEKI-----------DG----NEHFTCEEEGAFRSLIV----LNAELRDSGEYICDAQDDKVV 2024

  Fly   470 STHTINVLYPPAPPLISGYMEGQ---IIPAGSVQKLLCVSSGGNPLATLTWY------KNDKRIN 525
            .:.|:.    .||..|.|..:..   |:..|....|.|..|..|  |.:.||      |.|.|.:
Zfish  2025 FSVTVE----EAPVSIVGNTQKPKHCILLTGDELSLECEVSRVN--AVVQWYCNGRLLKQDSRTH 2083

  Fly   526 SVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEP-EEL 589
              |.::|  ...::.|....:.:..:|.|:|::... |.:.....|...|..:..|..|.. ||.
Zfish  2084 --IESSD--TMRKLVISGLQTSDSGEYLCDATDDKM-ITMLTVQDLPFKFIKKDEKTNISAYEED 2143

  Fly   590 RPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYT 654
            ...:.||:    :..|.|.|....:|.|..:..|.||..       :|....:|..:..:...||
Zfish  2144 SLTLRATV----NRVNAPIKWQRGRDLIRGDRFNTTSDG-------NTHYLTINPLKRGDSGEYT 2197

  Fly   655 CQSANEALQRSAH-EAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGT 718
            |....:.:..|.| :|:.:      ||..|..:.| |::|.::.:..:...:...|  :|.||..
Zfish  2198 CHLGTDEMHFSVHVKAMKV------KFSKPLENIA-GLKGSNVVLKCELYKSKGDV--QWLKDSQ 2253

  Fly   719 TIPQDGDHRIFADG--GSLNFTRLHRDDAGIYSCSASNSQGGAT--LNITVVVEYGTTIKSVSE- 778
            .|.......|.|:|  .||....:..||||.|:|.:.:.:..||  :||..:||:      |:| 
Zfish  2254 EIAASRHFTIRAEGRVRSLTIHNITEDDAGEYACESKDERTSATVMVNIPRIVEF------VAEL 2312

  Fly   779 -NIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTF---ANGTSY-LHIKDAKREDV 838
             |:.|..||||...|.|..:   :..:.|.:.|  ..:.::..|   :||..: ||||:.:..| 
Zfish  2313 HNMTVMEGEDATFKCVVSPE---DAKLSWFKNG--QHISSNEKFNISSNGLCHMLHIKNCQVSD- 2371

  Fly   839 GNFRCVADNRVDNPTNRDILLI----VKF--------APEIAKTPTLLRAASGTGERGRLPCRAQ 891
               .|......:...:|.:|.:    |.|        |.|..:....:..::.|.|   :....|
Zfish  2372 ---SCSLTAEAEGVISRALLQVQEAQVLFTKSMDPVVAEEFGEATLEVEVSTETAE---VQWMRQ 2430

  Fly   892 G---SPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG 953
            |   .|..:|..||..:                      :.:|.:.|:...|.|.|.|...::..
Zfish  2431 GVVIHPGSKFTLRQSGR----------------------KRSLTIHKLTLLDRGTYSCETLHDRT 2473

  Fly   954 EA-----------------VETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGG-LKASYR 1000
            :|                 ::|:..|..|..        :.::|..|...|..  ||. ||.:.|
Zfish  2474 QAKLSVEPRKIKIRKGLTDIQTIERETASFE--------VELSHSNVEGVWQK--DGHVLKTNNR 2528

  Fly  1001 VRYRMADREQYKYIDGLPNSHKLTIGGLRMNT--LYLFSVMSWNELGQSSYLPDLARAETKEAPP 1063
            :|.....|           .|.|||.||.::.  .|:|||         ..:..|||.:.||.| 
Zfish  2529 LRMTAQGR-----------VHSLTISGLTLDDTGTYIFSV---------DNVRSLARLDVKEIP- 2572

  Fly  1064 PSHPASSLGGGPPTTSQTPLGGTSGMLLVGV-----------GAGIVVVLLNVFVIGCCLHKRN- 1116
                                        |.:           |:|:        .:.|.|.:.| 
Zfish  2573 ----------------------------VSILKKLDDIRQPEGSGV--------TLECELSRHNI 2601

  Fly  1117 -EKRLKRGLELMPAELTEDSSNTPN--LVIIGISLAAFGFLLV---NASLVAWFFVHQRRKKVAE 1175
             .|..|.|::|.|.:.....|....  |.|:...|...|..:.   :|:......:::|..::.:
Zfish  2602 DIKWTKNGVQLKPGKNHRIYSMGRKCFLQILKCELGDSGLYVCDAGDATTSCSVDIYERELEILQ 2666

  Fly  1176 TTN----QPAKTATIEMYAPSSYNDTVTGE---------TLSSVSEKSE---------SYSNEGS 1218
            :..    |..:.|   ::......|.|.||         ..|::..:.|         :...|.|
Zfish  2667 SLEDLDIQEDQNA---VFMCEVSLDDVPGEWFKNGEKIKPTSTIKIRQEANKHFLLICNVKEEDS 2728

  Fly  1219 SQPEYIDEVRKKAASTYLVEGSDMP----PPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAI 1279
            .:.::   |.|...||..:|...:|    .|...|    .|:.....:..|||.:||     .:|
Zfish  2729 GEIKF---VAKNVESTAYLEVEALPANIVKPLQDK----TVLEKTRAIMDCTLTNPR-----CSI 2781

  Fly  1280 HMTRDDQMLISKGVYIPSPSPAPPPDGSY---------------YNMNSDRYLSYPPMEYPAALD 1329
            ...:      ...|.:||.......:|.|               |::....|.|      .|.|.
Zfish  2782 RWYK------GPNVILPSEHFEICSEGCYRKLVIQQVLLEDEGTYSVQVGNYTS------SARLT 2834

  Fly  1330 FTAQPMPMA-HLQPMTVT-----------SLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVG 1382
            ..||.:.|. .||.:.||           ||.....||...||.         ||.         
Zfish  2835 VEAQSILMVRELQDVNVTAPADACFECEISLPVAKAPTWTLNGE---------TLN--------- 2881

  Fly  1383 VPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSL 1426
             |.|:|.          ::.:..:|.:.|.    .||..::|::
Zfish  2882 -PSPNVV----------LEKMGTVHRLTLK----QTSEEMSGTV 2910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352 24/102 (24%)
Ig 76..155 CDD:299845 20/81 (25%)
IG_like 186..279 CDD:214653 27/172 (16%)
Ig 197..279 CDD:299845 24/154 (16%)
IG_like 296..376 CDD:214653 25/105 (24%)
Ig 300..361 CDD:299845 18/76 (24%)
Ig 380..454 CDD:299845 11/73 (15%)
IG_like 490..573 CDD:214653 20/91 (22%)
Ig 501..560 CDD:299845 16/64 (25%)
Ig 584..666 CDD:299845 18/82 (22%)
IG_like 585..666 CDD:214653 17/81 (21%)
I-set 678..767 CDD:254352 26/92 (28%)
IGc2 692..757 CDD:197706 17/66 (26%)
Ig 788..849 CDD:143165 14/64 (22%)
Ig 885..960 CDD:143165 14/94 (15%)
FN3 967..1051 CDD:238020 20/86 (23%)
obsl1bXP_021334748.1 I-set 8..97 CDD:254352
I-set 112..205 CDD:254352
I-set 257..337 CDD:254352
I-set 343..413 CDD:333254
I-set 434..>497 CDD:333254
FN3 522..606 CDD:238020
I-set 622..>687 CDD:333254
Ig 720..>784 CDD:325142
Ig 819..889 CDD:325142
Ig_3 908..967 CDD:316449
Ig 1004..1059 CDD:319273
Ig 1319..1387 CDD:319273
Ig 1411..1468 CDD:319273
Ig 1503..1559 CDD:319273 8/32 (25%)
I-set 1589..1655 CDD:333254 19/73 (26%)
I-set 1684..1740 CDD:333254 6/55 (11%)
Ig 1779..>1832 CDD:319273 18/69 (26%)
IG_like 1862..1932 CDD:214653 19/86 (22%)
IG_like 1960..2030 CDD:214653 18/90 (20%)
IG 2051..2121 CDD:214652 18/76 (24%)
IG 2136..2211 CDD:214652 19/85 (22%)
I-set 2217..2298 CDD:333254 23/83 (28%)
I-set 2307..2390 CDD:333254 24/97 (25%)
I-set 2397..2466 CDD:333254 16/93 (17%)
I-set 2485..2559 CDD:333254 23/103 (22%)
I-set 2574..2655 CDD:333254 16/88 (18%)
I-set 2663..2746 CDD:333254 14/88 (16%)
I-set 2753..2835 CDD:333254 19/102 (19%)
I-set 2842..2925 CDD:333254 21/102 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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