DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Vsig2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_065264.2	Gene:	Vsig2 / 57276	MGIID:	1928009	Length:	328	Species:	Mus musculus

Alignment Length:	362	Identity:	75/362 - (20%)
Similarity:	133/362 - (36%)	Gaps:	95/362 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 GATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVE----------------GKPL------- 799
            |..:.:||          .:|.:.|..|:.|.|||:.:                |||:
Mouse    22 GLAVEVTV----------PTEPLSVPKGKTAELSCSYKTSVGDNFALEWSFVQPGKPISASVPVL 76

  Fly   800 --TEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVK 862
              |..|:.......|..:........|.:.|.:.|.:..|.|.:.|..:|..|..||.  |.::.
Mouse    77 YFTNGHLYPTGSKADRAILLHDPPTGGLATLKLTDLRPSDTGTYLCNVNNPPDFYTNG--LGLIN 139

  Fly   863 FAPEIAKTPTLLRAASGT--GERGRLPCR-AQGSPKPQFIWRQ--DKKDLPINRTYKYEVEERKI 922
            ....:..:..|...:..|  |....|.|| ::|:|||.:.|.:  .....|.....:.||
Mouse   140 LTVLVPPSHPLCSQSGQTSVGGSAALGCRSSEGAPKPVYNWERLGSSPTPPPGSMVQDEV----- 199

  Fly   923 DSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAW 987
                 ...||:..::....|.|.|||.|::|.|...:.|.:|...:..::..::.|....:.|:
Mouse   200 -----SGQLILTNLSLTSSGTYRCVASNQMGSASCELNLSVTDSSEGRVAGTLIGVLLGVLLLS- 258

  Fly   988 TPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPD 1052
                   :.|...:|::   :|:.|       ..|.|.||              ::|.:.:..|.
Mouse   259 -------VAAFCLIRFQ---KERKK-------EPKETYGG--------------SDLREDATAPG 292

  Fly  1053 L-----ARAE-TKEAPPPSHPASSLGGGPPTTSQTPL 1083
            :     .||: :||....|..||::     ||:::.|
Mouse   293 VFEQASMRADHSKELLEKSPCASTM-----TTTKSKL 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	3/8 (38%)
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165	17/85 (20%)
		Ig	885..960	CDD:143165	21/77 (27%)
		FN3	967..1051	CDD:238020	11/83 (13%)
Vsig2	NP_065264.2	V-set	32..143	CDD:284989	24/112 (21%)
		IG_like	32..142	CDD:214653	24/111 (22%)
		IG_like	152..235	CDD:214653	24/92 (26%)
		Ig	153..231	CDD:299845	23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910