DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and si:ch73-22o12.1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_021322530.1	Gene:	si:ch73-22o12.1 / 560816	ZFINID:	ZDB-GENE-110411-27	Length:	505	Species:	Danio rerio

Alignment Length:	372	Identity:	83/372 - (22%)
Similarity:	136/372 - (36%)	Gaps:	100/372 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTK--------DGFALGFSAVIPGF----PRYS 124
            |..|..| ::....|....:||:..| .|..|.|:        |......:...|.|    |..|
Zfish    21 QHVRVEP-EVVSFPGQTVTLRCQFPN-PGDTQLTQVSWIFERTDTERTNIAVFHPNFGVNYPTTS 83

  Fly   125 VLGDRKQGIYN--------LRISNASINDDADYQCQVG--PARLNSAIRANAKLTVISPPASIEI 179
            .:..|...:.|        ::|.:..:.|:..|.|:..  |:.....:   :.|.:::.|
Zfish    84 PVSGRVTFVSNPPTLDNPSIQIKDVKMTDEGRYICEYATYPSGNEQGV---SSLVMLAKP----- 140

  Fly   180 KGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVW---YRGNV--EYKPEKREDTVEESTAKRFTT 239
            |..:....|...:...:..:|..:|.:|||.|.|   ..|||  ..|.:..::||        :.
Zfish   141 KNTATTVTVSAGKTPVIVARCESSNGRPAATITWSTALNGNVTTPKKTDNPDNTV--------SI 197

  Fly   240 TSSLKLKPGPDDDYTEYTCQARHKALS-PD-MPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQT 302
            .|...|.|.|:|:..:.:|...|:.:: |: .||:..|:    ||| ...|:||:  ....||||
Zfish   198 QSVYMLAPQPEDNGKDISCIVSHRTMAQPETFPMKLVVE----YPP-VVQIKGYN--NNWYRGQT 255

  Fly   303 -VELMCRSRGGNPPAQLIWYKNGSQIRMAYRT-SGRLSENIYTFTAEAGDNK-----------AR 354
             ..|.|.:.|...|..:.|           :| ||.:.|     |.:..:|:           ..
Zfish   256 SAHLTCHADGNPVPTTVTW-----------KTLSGHMPE-----TVQVRENRLAVQQVDDTINTT 304

  Fly   355 FRCEASNVMSQNPLKAEVELSVLFAPTHVTVM----GPTEARVGDIV 397
            |.||..|             |:.:....|||:    .|..:..|.||
Zfish   305 FICEVKN-------------SLGYGRDQVTVVVREQAPPNSNAGVIV 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	22/118 (19%)
		Ig	76..155	CDD:299845	19/100 (19%)
		IG_like	186..279	CDD:214653	25/99 (25%)
		Ig	197..279	CDD:299845	24/88 (27%)
		IG_like	296..376	CDD:214653	19/92 (21%)
		Ig	300..361	CDD:299845	17/73 (23%)
		Ig	380..454	CDD:299845	7/22 (32%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
si:ch73-22o12.1	XP_021322530.1	Ig1_PVR_like	35..137	CDD:319295	19/105 (18%)
		Ig2_Nectin-2_like	140..235	CDD:319328	26/107 (24%)
		Ig	257..314	CDD:325142	16/85 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910