DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Pxdn

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001258190.1	Gene:	Pxdn / 554172	RGDID:	1560694	Length:	1475	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	226/1053 - (21%)
Similarity:	373/1053 - (35%)	Gaps:	246/1053 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   538 EITILANVSDNQAQYRCEASNSATEIP-LFQSTTLSVHFAPETV-----KIRIEPE--ELRPGME 594
            ||..||::....||.....:.:..|.| ..|..:::. ..||.:     :|..||:  ::..|..
  Rat   196 EILWLADLLKTYAQSGNAQAAATCEYPRRIQGRSVAT-ITPEELNCERPRITSEPQDADVTSGNT 259

  Fly   595 ATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN 659
            ....| .:..||..::.|.::...:....::....|..||:     .:..|||.:..||.|.:.|
  Rat   260 VYFTC-RAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTL-----MIQNTQEADEGVYQCMAKN 318

  Fly   660 EALQRSAHEAVSLDVL---YRPKFVPPPSSTAVGVEGESLQVSLQTRANPTP-VTYKWTK-DGTT 719
            .|.:...|| |:|..|   .||.||..|.:|.|.| |||:.:......:|.| :|  ||: |.|.
  Rat   319 VAGEAKTHE-VTLRYLGSPARPTFVIQPQNTEVLV-GESVTLECSATGHPLPQIT--WTRGDRTP 379

  Fly   720 IPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNP 784
            :|.|....|...|| |....:.:.|:|.|:|.||||.........::|:.........::.||..
  Rat   380 LPIDPRVNITPSGG-LYIQNVAQSDSGEYTCFASNSVDSIHATAFIIVQALPQFTVTPQSRVVIE 443

  Fly   785 GEDAMLSCTVEGKPLTEEHVKWERVGYDMTV-KTSTTFANGTSYLHIKDAKREDVGNFRCVADNR 848
            |:.....|..:|.|  :..:.|.:.|..::| :.....::||  |.|......|.|.:.|.|.|.
  Rat   444 GQTVDFQCEAKGYP--QPVIAWTKGGSQLSVDRRHLVLSSGT--LRISGVALHDQGQYECQAVNI 504

  Fly   849 V-DNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRT 912
            : .......:.:..:..|..|..|:.:....||..  :|||.:||.|:|...|.:|  .:.:..:
  Rat   505 IGSQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNV--QLPCSSQGEPEPAITWNKD--GVQVTES 565

  Fly   913 YKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRL-----EITSQPDPPLS 972
            .|:.:..        |..|.::.|..||.|.|||||||.:|.|..::.|     :::...||.::
  Rat   566 GKFHISP--------EGFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPDVSRNGDPYVA 622

  Fly   973 LNILN--VTHD-TVTLAWTPGFD------GGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGL 1028
            .:|:.  .|.| .:....|..||      ..|.|.:|.     .|:.|            |:|..
  Rat   623 TSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRY-----PRDPY------------TVGQA 670

  Fly  1029 RMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVG 1093
            |...::..::....|..|...:.|                              |.|||......
  Rat   671 RAGEIFERTLQLIQEHVQHGLMVD------------------------------LNGTSYHYNDL 705

  Fly  1094 VGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNA 1158
            |....:.::.|  :.||..|:|                                       :.|.
  Rat   706 VSPQYLSLIAN--LSGCTAHRR---------------------------------------VNNC 729

  Fly  1159 SLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEY 1223
            |.:.:   ||:.:....|.|              :....:.|.:|::.....::....|.:.|..
  Rat   730 SDMCF---HQKYRTHDGTCN--------------NLQHPMWGASLTAFERLLKAVYENGFNTPRG 777

  Fly  1224 IDEVRKKAASTYLVEGSDMPPPRYQKD---GTLPVIYPNNVVNACTLPHPR---HNNGSAAIHMT 1282
            |:..|:       ..|..:|.||....   || .||.|:.......:...:   |:..|..:.::
  Rat   778 INSQRQ-------YNGHVLPMPRLVSTTLIGT-EVITPDEQFTHMLMQWGQFLDHDLDSTVVALS 834

  Fly  1283 RDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQPMTVTS 1347
               |...|.|.:..|.....||..|.....:|     |.:...|...|..:..|:.   ...:||
  Rat   835 ---QARFSDGQHCSSVCSNDPPCFSVMIPPND-----PRVRSGARCMFFVRSSPVC---GSGMTS 888

  Fly  1348 LATNG--------------------GPTLIGNGSVAAVAGGSGTLRRGILRGVVGVP-QPDVTHH 1391
            |..|.                    |.|.....|:..:|...|.||:||::. .|.| .|..|
  Rat   889 LLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQR-SGKPLLPFAT-- 950

  Fly  1392 TSTVGGSPMQMLHDLH--PVNLSASTLTTSTTLNGSLP-TATATLPRQPHGILKDPNRNKQQQQQ 1453
                 |.|.:.:.|.:  |:   ...|......|..|. |:..||..:.|      ||...:..:
  Rat   951 -----GPPTECMRDENESPI---PCFLAGDHRANEQLGLTSMHTLWFREH------NRIAAELLK 1001

  Fly  1454 QQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQILN----LPPASGGLGNNLLMTTNAFDPT 1514
            .........:.|:.:    .:||         ..:|.:.    ||...|.:|..:|.....:||
  Rat  1002 LNPHWDGDTVYHETR----KIVG---------AEIQHITYRHWLPKILGEVGMKMLGEYRGYDP- 1052

  Fly  1515 TVGLSSFGAVSQA 1527
            :|....|.|.:.|
  Rat  1053 SVNAGIFNAFATA 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	9/35 (26%)
		Ig	501..560	CDD:299845	6/21 (29%)
		Ig	584..666	CDD:299845	18/83 (22%)
		IG_like	585..666	CDD:214653	18/82 (22%)
		I-set	678..767	CDD:254352	31/90 (34%)
		IGc2	692..757	CDD:197706	24/66 (36%)
		Ig	788..849	CDD:143165	15/61 (25%)
		Ig	885..960	CDD:143165	25/74 (34%)
		FN3	967..1051	CDD:238020	18/92 (20%)
Pxdn	NP_001258190.1	leucine-rich repeat	42..60	CDD:275380
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	107..148	CDD:289563
		LRR_8	108..167	CDD:290566
		leucine-rich repeat	109..132	CDD:275378
		LRR_4	132..172	CDD:289563
		leucine-rich repeat	133..156	CDD:275378
		LRR_8	155..>192	CDD:290566
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..193	CDD:275378
		TPKR_C2	189..240	CDD:301599	11/44 (25%)
		Ig	243..330	CDD:299845	22/93 (24%)
		I-set	243..330	CDD:254352	22/93 (24%)
		I-set	339..426	CDD:254352	31/90 (34%)
		Ig	343..426	CDD:299845	28/86 (33%)
		I-set	430..516	CDD:254352	18/89 (20%)
		Ig3_Peroxidasin	443..516	CDD:143222	16/76 (21%)
		I-set	522..608	CDD:254352	31/97 (32%)
		Ig4_Peroxidasin	539..607	CDD:143223	25/79 (32%)
		An_peroxidase	738..1279	CDD:281139	76/392 (19%)
		peroxidasin_like	861..1300	CDD:188658	50/244 (20%)
		VWC	1411..1466	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910