DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Nphs1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	1262	Identity:	369/1262 - (29%)
Similarity:	586/1262 - (46%)	Gaps:	119/1262 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HWIKHLQLLRLLAVIV--LASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTK 106
            |...||..|.|..::.  ||.:|||:.| .:.|.....:|.|:||:...:.|.|......|||.|
Mouse    17 HRTCHLIPLLLAGMLTTGLAQSPVPTSA-PRGFWALSENLTVVEGSTVKLWCGVRAPGSVVQWAK 80

  Fly   107 DGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLN-SAIRANAKLTV 170
            ||..||.:..||||||||:.||..:|.::|.|....::|||:|:||||.:.|. ..:..:..|::
Mouse    81 DGLLLGPNPKIPGFPRYSLEGDSAKGEFHLLIEACDLSDDAEYECQVGRSELGPELVSPSVILSI 145

  Fly   171 ISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRG--NVEYKPEKREDTVEEST 233
            :..|..:::...: .|.|.....|:..:.|:..:||||..|::.:|  .||   :......|.|.
Mouse   146 LVSPKVLQLTPEA-GSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTVE---DVSSSVNEGSE 206

  Fly   234 AKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIE--GYSAGET 296
            .|.|.|.:..::.|...|:.....|:..:.||:  .|::|:..:::|:|||||.|:  |.:.|.
Mouse   207 EKLFFTEAEARVTPQSSDNGQLLVCEGSNPALA--TPIKASFTMNILFPPGPPVIDWPGLNEGH- 268

  Fly   297 LRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRT--SGRLSENIYTFTAEAGDNKARFRCEA 359
            :|.|:.:||.|.:|||||||.|.|.|||..:.:|:.|  :..::.::...|....|:.||..|::
Mouse   269 VRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQAVAHSVLVMTVRPEDHGARLSCQS 333

  Fly   360 SNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNA 424
            .|.:|....:..:.|.|.|.|:.||::|.|.......|.|.|.|..|.|...::|.:||||:. .
Mouse   334 YNSVSAETQERSITLQVTFPPSAVTILGSTSQSENKNVTLCCLTKSSRPRVLLRWWLGGRQLL-P 397

  Fly   425 TSKTIVSP-EGGWTTTSNITAVVEPNKRSLVVICHGLNMQLT-ENVVSTHTINVLYPPAPPLISG 487
            |.:|::.. .||..:.||:|.:|:.....|.:.|...:...: |....:.|:||.||.....|.|
Mouse   398 TDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQKLWIEG 462

  Fly   488 YMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRIN-------------SVIRAADKSVSAEI 539
            ..|||.|..|:..:|:|::.||||..:|||.|:.:.:|             ..:..:..:.|.|:
Mouse   463 PPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKSGSTFSREL 527

  Fly   540 TILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSS 604
            .::....||.|::.|:|..      |..||.|.|.|.|..:.|......||||....:.|.|.||
Mouse   528 VLIIGPPDNLAKFSCKAGQ------LSASTQLVVQFPPTNLTILANSSALRPGDALNLTCVSISS 586

  Fly   605 NPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEA 669
            |||..||..|:|..::.:....:...:.|:.::....:.|:...:|...||::.:|||:.:....
Mouse   587 NPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHSEALRETVSSF 651

  Fly   670 VSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGD--HRIFADG 732
            ..|:|||.|:|:.........||.....:.:...|||.|..:.||..|..:...|.  |||.: |
Mouse   652 YRLNVLYPPEFLGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILS-G 715

  Fly   733 GSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGK 797
            |:|....:.|.|.|.|.....||:|.|...:.:.|.|..||:::.:...||.|....:.|||:..
Mouse   716 GALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDAN 780

  Fly   798 PLTEEHVKWERVGYD---MTVKTSTTFANG-TSYLHIKDAKREDVGNFRCVADNRVDNPTNRDIL 858
            |:..|...|||:|.|   :.:......:.| |..|.|:.||....|.::|:.||.|.......:.
Mouse   781 PILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVR 845

  Fly   859 LIVKFAPEI-AKTP-TLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERK 921
            |:|:|||:: ..|| |.:.||..:.....|.|||:|.|...|.|  .|..:|::.......|.:.
Mouse   846 LVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTW--TKNGVPLDLQDPRYTEHKY 908

  Fly   922 IDSLTYESTLIVDKVAPA-DYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTL 985
            ...:.:.|.|.:..|:.| ||..::|.|.|.||.....::|...|:|||||.|.:::|:..:|.|
Mouse   909 HQGVVHSSLLTIANVSAAQDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSVSPHSVGL 973

  Fly   986 AWTPGFDGGLKASYRVRYRMADREQYKYIDGLP-NSHKLTIGGLRMNTLYLFSVMSWNELGQSSY 1049
            .|.|||||||...:::||...:...:.|:|.|| .:...|:.||:.:|.|...:::.|.||.|..
Mouse   974 EWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGL 1038

  Fly  1050 LPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHK 1114
                    |.:....|.....|...|..|.| ||.
Mouse  1039 --------TDKGIQVSITTPGLDQAPEDTDQ-PLP------------------------------ 1064

  Fly  1115 RNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLV-NASLVAWFFVHQRRKKVAETTN 1178
                             ||.....|.|.::.:..|..|.||: |||.|......:|.:::||..:
Mouse  1065 -----------------TEQPPGPPRLPLLPVLFAVGGLLLLSNASCVGGLLWRRRLRRLAEEIS 1112

  Fly  1179 QPAKTATIEMYAPSSYNDTV-TGE------TLSSVSEKSESYSNEGSSQ--PEYIDEVRKKAAST 1234
            :..:..:.|....:.|.::. ||:      |:|:.......||....|.  |..::||..:.|.|
Mouse  1113 EKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVSTAEVDPHYYSMRDFSPQLPPTLEEVSYRQAFT 1177

  Fly  1235 YLVEGSDMPPPRYQKDGTLPVIYPNNV 1261
            . :|..||..|.:..|....|..|..|
Mouse  1178 G-IEDEDMAFPGHLYDEVERVYGPPGV 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	38/97 (39%)
		Ig	76..155	CDD:299845	34/78 (44%)
		IG_like	186..279	CDD:214653	24/94 (26%)
		Ig	197..279	CDD:299845	21/83 (25%)
		IG_like	296..376	CDD:214653	27/81 (33%)
		Ig	300..361	CDD:299845	23/62 (37%)
		Ig	380..454	CDD:299845	24/74 (32%)
		IG_like	490..573	CDD:214653	27/95 (28%)
		Ig	501..560	CDD:299845	18/71 (25%)
		Ig	584..666	CDD:299845	23/81 (28%)
		IG_like	585..666	CDD:214653	23/80 (29%)
		I-set	678..767	CDD:254352	26/90 (29%)
		IGc2	692..757	CDD:197706	21/66 (32%)
		Ig	788..849	CDD:143165	20/64 (31%)
		Ig	885..960	CDD:143165	22/75 (29%)
		FN3	967..1051	CDD:238020	32/84 (38%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845	33/75 (44%)
		IG_like	52..127	CDD:214653	32/74 (43%)
		C2-set_2	155..242	CDD:285423	22/92 (24%)
		Ig	254..332	CDD:299845	30/78 (38%)
		IG_like	268..350	CDD:214653	27/82 (33%)
		C2-set_2	358..440	CDD:285423	24/82 (29%)
		Ig	459..544	CDD:299845	24/84 (29%)
		I-set	460..555	CDD:254352	29/100 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		4/24 (17%)
		Ig	563..646	CDD:299845	24/82 (29%)
		IG_like	670..750	CDD:214653	24/80 (30%)
		Ig	676..750	CDD:299845	22/74 (30%)
		Ig_3	753..834	CDD:290638	23/80 (29%)
		IG_like	762..848	CDD:214653	25/85 (29%)
		Ig	848..956	CDD:299845	33/109 (30%)
		IG_like	859..949	CDD:214653	26/91 (29%)
		fn3	956..1039	CDD:278470	31/90 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		8/70 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		4/30 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833720
Domainoid	1	1.000	64	1.000	Domainoid score	I10109
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20974
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1366
Isobase	1	0.950	-	0	Normalized mean entropy	S6746
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm42390
orthoMCL	1	0.900	-	-		OOG6_107508
Panther	1	1.100	-	-	LDO	PTHR11640
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4392
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740