DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Flt1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	1306	Identity:	261/1306 - (19%)
Similarity:	387/1306 - (29%)	Gaps:	527/1306 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNAS 142
            |..:.:.||.|.::.|.|.:....|...|    ..|.|:.|...|  :..|.::|..   |:||:
  Rat   143 PKLVHMTEGRELIIPCRVTSPNITVTLKK----FPFDALTPDGQR--IAWDSRRGFI---IANAT 198

  Fly   143 INDDADYQCQVGPARLNSAIRANAKLT----------VISPPASIEIKGYSHNSKVEVRENQDLQ 197
            ..:.....|:   |.:|..:...:.||          .||||           |.|.....|.|.
  Rat   199 YKEIGLLTCE---ATVNGHLYQTSYLTHRQTNTILDVQISPP-----------SPVRFLRGQTLV 249

  Fly   198 LKC-IVANAKPAAQIVW-YRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQA 260
            |.| :..:.....|:.| |.|....:...|: .:::|........|.||:......|...|||
  Rat   250 LNCTVTTDLNTRVQMSWNYPGKATKRASIRQ-RIDQSNPHSNVFHSVLKINNVESRDKGLYTC-- 311

  Fly   261 RHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGN--------PPAQ 317
            |.|:.|.......:|.:         |.:|:.:.:. |:.|..|.:...|...        |..:
  Rat   312 RVKSGSSFRTFNTSVHV---------YEKGFISVKH-RKQQVQETIAGKRSHRLSMKVKAFPSPE 366

  Fly   318 LIWYKNGSQIRMAYRTSGRLSENIYTF-----TAE-AGDNKARFRCEASNVMSQNPLKAEVELSV 376
            ::|.|:|..   |...|.|.|.:.|:.     ||| |||
  Rat   367 VVWLKDGVP---ATEKSARYSVHGYSLIIKDVTAEDAGD-------------------------- 402

  Fly   377 LFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSN 441
                 :..::|..::::                           .||.|:..||:
  Rat   403 -----YTILLGIKQSKL---------------------------FRNLTATLIVN---------- 425

  Fly   442 ITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVS 506
                |:|              |:.|..||:       .|:|||         .|.||.|.|.| :
  Rat   426 ----VKP--------------QIYEKSVSS-------LPSPPL---------YPLGSRQVLTC-T 455

  Fly   507 SGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTL 571
            ..|.|..|:.|                                ..:.|..::|.
  Rat   456 VYGIPQPTIKW--------------------------------LWHPCHYNHSK----------- 477

  Fly   572 SVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVS 636
                         |..:...|.|.:.|.||||:          .|..||||
  Rat   478 -------------ERNDFCFGSEESFILDSSSN----------IGNRIEGI-------------- 505

  Fly   637 TLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVS-L 700
                    ||.|                                        :.:||.:..|| |
  Rat   506 --------TQRM----------------------------------------MVIEGTNKTVSTL 522

  Fly   701 QTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITV 765
            ....:.||                                     |||||.|.|..|....:|..
  Rat   523 VVADSRTP-------------------------------------GIYSCKAFNKIGTVERDIRF 550

  Fly   766 VVEYGTTIKS---VSENIVVNPGEDAMLSCTVEGKPLTEEHVKW--ERVGYDMTV-------KTS 818
               |.|.:.:   ||...:...|||..|||.| .|.|..: :.|  .|...:.|:       |.:
  Rat   551 ---YVTDVPNGFHVSLEKIPTEGEDLKLSCVV-SKFLYRD-ITWILLRTVNNRTMHHSISKQKMA 610

  Fly   819 TTFANG-TSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLR------- 875
            ||.... |..|.||:...||.|.:.|.|.|..   |..:||...:......:.|.||:
  Rat   611 TTQDYSITLNLVIKNVSLEDSGTYACRARNIY---TGEEILRKTEVLVRDLEAPLLLQNLSDHEV 672

  Fly   876 AASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPAD 940
            :.||:   ..|.|:|:|.|.||..|        ....:|.: :|..|......|||.:::|...|
  Rat   673 SISGS---TTLDCQARGVPAPQITW--------FKNNHKIQ-QEPGIILGPGNSTLFIERVTEED 725

  Fly   941 YGAYECVARNELGEAVETVRLEITSQPDPP-LSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYR 1004
            .|.|.|.|.|:.|....:..|.:....|.. |.|..|..|....||.|       |..:..:|
  Rat   726 EGVYRCRATNQKGVVESSAYLTVQGTSDKSNLELITLTCTCVAATLFW-------LLLTLFIR-- 781

  Fly  1005 MADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNEL---GQSSYLP------DLARAETKE 1060
                             ||......:.|.||..:|..:|:   .|...||      :.||...|
  Rat   782 -----------------KLKRSSSEVKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLK- 828

  Fly  1061 APPPSHPASSLGGG---------------PPTTSQTPL-----GGTSG---------MLLVGVGA 1096
                  ...|||.|               .||.....:     |.|:.         .:|..:|.
  Rat   829 ------LGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGH 887

  Fly  1097 GIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFG--------- 1152
            .:.||.|    :|.|        .|:|..||                :.:....:|
  Rat   888 HLNVVNL----LGAC--------TKQGGPLM----------------VIVEYCKYGNLSNYLKSK 924

  Fly  1153 --FLLVNASLVAWFFVHQRRKKVAETTNQPAK-----TATIEMYAPS------SYNDTVTGETLS 1204
              |..:|..  |...:..:::|:.....|..|     .::.|.:..|      |.:|...||..|
  Rat   925 RDFFCLNKD--AALHMEPKKEKLEPDLEQDQKPRLDSVSSSESFTSSGFQEDKSVSDVEGGEDYS 987

  Fly  1205 SVS------EKSESYSNEGSSQPEYIDE----VRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPN 1259
            .:|      |...|||.:.:...|::..    .|..||...|:.                   .|
  Rat   988 EISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS-------------------EN 1033

  Fly  1260 NVVNAC 1265
            |||..|
  Rat  1034 NVVKIC 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	22/101 (22%)
		Ig	76..155	CDD:299845	18/76 (24%)
		IG_like	186..279	CDD:214653	23/94 (24%)
		Ig	197..279	CDD:299845	19/83 (23%)
		IG_like	296..376	CDD:214653	19/93 (20%)
		Ig	300..361	CDD:299845	18/74 (24%)
		Ig	380..454	CDD:299845	8/73 (11%)
		IG_like	490..573	CDD:214653	12/82 (15%)
		Ig	501..560	CDD:299845	7/58 (12%)
		Ig	584..666	CDD:299845	16/81 (20%)
		IG_like	585..666	CDD:214653	16/80 (20%)
		I-set	678..767	CDD:254352	16/89 (18%)
		IGc2	692..757	CDD:197706	14/65 (22%)
		Ig	788..849	CDD:143165	22/70 (31%)
		Ig	885..960	CDD:143165	22/74 (30%)
		FN3	967..1051	CDD:238020	18/87 (21%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653	20/87 (23%)
		IG_like	237..328	CDD:214653	24/104 (23%)
		Ig	245..327	CDD:299845	20/84 (24%)
		Ig	353..424	CDD:299845	19/131 (15%)
		IG_like	439..552	CDD:214653	48/290 (17%)
		Ig	451..549	CDD:143165	39/263 (15%)
		IG	568..640	CDD:214652	24/73 (33%)
		IGc2	569..640	CDD:197706	24/72 (33%)
		I-set	661..748	CDD:254352	28/98 (29%)
		IGc2	676..738	CDD:197706	22/73 (30%)
		PKc_like	819..1157	CDD:304357	51/277 (18%)
		Pkinase_Tyr	827..1154	CDD:285015	49/269 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910