DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and mybpc2b

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001013529.2	Gene:	mybpc2b / 541384	ZFINID:	ZDB-GENE-050320-80	Length:	1111	Species:	Danio rerio

Alignment Length:	1088	Identity:	216/1088 - (19%)
Similarity:	371/1088 - (34%)	Gaps:	327/1088 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 VLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDA 147
            |.:|.:.:|..|||:....|:|.::|..:..||      :|.:..|  ..|..|.|:..|:.|||
Zfish   233 VNKGKKIVMSVEVADPNAEVKWLRNGQEIKPSA------KYIMEAD--GNIRTLTINKCSLADDA 289

  Fly   148 DYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIV 212
            .|:|.||      ..:...::.|..||  |.|.....:..|.|.|..:.:::.    ::..|.::
Zfish   290 AYECVVG------TDKCFTEVFVKEPP--ITITKLLDDYHVVVGERVEFEIEV----SEEGAHVI 342

  Fly   213 WYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQL 277
            |.   .|.:...|||   :.:..||.       |.|           .||..:         :|.
Zfish   343 WL---FEDQQLSRED---KDSKYRFK-------KDG-----------KRHCLI---------IQE 374

  Fly   278 SVLYPPGPPYI---EGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSE 339
            :.|...|..|:   .|.|.||.:...:.:|::                                :
Zfish   375 ATLEDNGMFYVYTNGGQSKGELIVEEKELEVL--------------------------------Q 407

  Fly   340 NIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA 404
            :|...|.::.: :|.|:||.|          :.:::..:....|.|:.....::..|..:...|.
Zfish   408 SIADLTVKSAE-QAMFKCEVS----------DEKVTGKWFKDGVEVLPSDRIKISHIGRIHRLTI 461

  Fly   405 PSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVV 469
            ....|.:            |...|.| |:|                       :.|::....|.:
Zfish   462 DDVKPGD------------AGDYTFV-PDG-----------------------YALSISAKLNFL 490

  Fly   470 STHTINVLYPPA--PPLI----SGYMEGQ---IIPAGSVQKL-LCVSSGGNPLATLTWYKNDKRI 524
            .   |.:.|.|.  ||.|    ||.|..|   |:.||:  || |.|...|.|..|:.|.::||.:
Zfish   491 E---IKIDYVPRQDPPKIHLDVSGNMVSQNTIIVVAGN--KLRLDVEITGEPAPTVCWMRDDKPV 550

  Fly   525 NSV---IRAADKSVSAEITILANVSDNQAQYRCEASNSATE--IPLFQSTTLSVHFAPETVKIRI 584
            ...   :|..:|...:...|.....:::..|....:|.|.|  ..|| ...:.|...||.||...
Zfish   551 TDSEGRVRVENKKDLSCFIIEGAEREDEGNYTITVTNPAGEDKANLF-IKIVDVPDPPENVKCTG 614

  Fly   585 EPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEG-INNTSKPG--LWGGTVSTLEFRVNVTQ 646
            ..|:     .|.|:.|     ||.    :..|.|::| :....|.|  .|              .
Zfish   615 VGED-----TANIVWD-----PPK----FDGGAPLKGYLMERKKKGSSRW--------------T 651

  Fly   647 EMNGQVYTCQSANEALQRSAHEAVSL--DVLYRPKFVPPPSSTAVGVEGESLQ----VSLQTRAN 705
            ::|..||         :.:.:||..:  .:||..:..   :...:|:...||.    :.:...:.
Zfish   652 KLNFDVY---------ESTTYEAKRMIEGILYEMRVF---AVNGIGISAPSLNSKPFMPIAPTSE 704

  Fly   706 PTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCS----ASNSQGGATLNITVV 766
            ||.:|.                               ||....:||    |....|...|:
Zfish   705 PTKLTV-------------------------------DDVTDTTCSLKWLAPEKIGAGGLD---- 734

  Fly   767 VEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIK 831
               |..|:...|      ||.                 :|.....|:..:.|..         ::
Zfish   735 ---GYIIEFCKE------GES-----------------EWHPANTDLVERQSFV---------VR 764

  Fly   832 DAKREDVGNFRCVADN--------RVDNP-TNRDILLIVKF-APEIAKTPTLLRAASGTGERGRL 886
            :....:..|||.||.|        .:..| |.|:|:...|. .|...:|..:.|    .||:..|
Zfish   765 NLPTGEKMNFRVVAVNIAGRSPPALLGQPVTVREIMEHPKIRLPRDLRTKYIRR----VGEKINL 825

  Fly   887 PCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADY-GAYECVARN 950
            ....||.|:|...|.:|.:  |::.. |..|....:||:.:      .:.|..|: |.|....:.
Zfish   826 VIPFQGKPRPIATWLKDGQ--PVDEK-KVGVRNSNVDSILF------IRAAERDHSGKYTLTLKI 881

  Fly   951 ELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYID 1015
            |..|...|:.:.|..:|.||:.:::.:|......|.|.|..|.|.........:.|:::..::..
Zfish   882 ENMEDSATIEIRIVDKPGPPIGVHVTDVWGFNAALEWKPPKDDGNCEITGYTIQKAEKKTKEWFT 946

  Fly  1016 GLPNSHK--LTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAET------KEAPPPSHPASSLG 1072
            ...::.:  .|:..|.:...|:|.|.|.|..|.|.. |.:::...      .:..||.:....:.
Zfish   947 VYEHNRRTNCTVSDLIIGNEYMFRVYSENLCGLSED-PCMSKNNAIISKSGLDYKPPPYKEKDMN 1010

  Fly  1073 GGPPTTSQTPLGGTSGMLLVGVGAGI-----------VVVLLNVFVIG 1109
            ..|..|:  ||  ....:.:|....|           ::.:.|..:||
Zfish  1011 CAPKFTA--PL--VDRAVTIGYSTAISCAVRAFPKPKIIWMKNKMIIG 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	24/86 (28%)
		Ig	76..155	CDD:299845	23/71 (32%)
		IG_like	186..279	CDD:214653	16/92 (17%)
		Ig	197..279	CDD:299845	13/81 (16%)
		IG_like	296..376	CDD:214653	8/79 (10%)
		Ig	300..361	CDD:299845	7/60 (12%)
		Ig	380..454	CDD:299845	10/73 (14%)
		IG_like	490..573	CDD:214653	23/91 (25%)
		Ig	501..560	CDD:299845	15/62 (24%)
		Ig	584..666	CDD:299845	15/84 (18%)
		IG_like	585..666	CDD:214653	15/83 (18%)
		I-set	678..767	CDD:254352	13/96 (14%)
		IGc2	692..757	CDD:197706	10/72 (14%)
		Ig	788..849	CDD:143165	9/68 (13%)
		Ig	885..960	CDD:143165	19/75 (25%)
		FN3	967..1051	CDD:238020	19/85 (22%)
mybpc2b	NP_001013529.2	IG_like	33..128	CDD:214653
		I-set	223..306	CDD:254352	24/86 (28%)
		Ig	224..295	CDD:299845	22/69 (32%)
		IG_like	319..398	CDD:214653	23/115 (20%)
		Ig	420..>473	CDD:143165	11/74 (15%)
		Ig_C5_MyBP-C	515..600	CDD:143302	23/87 (26%)
		IG_like	518..600	CDD:214653	22/84 (26%)
		FN3	604..690	CDD:238020	24/125 (19%)
		FN3	703..795	CDD:238020	25/161 (16%)
		I-set	803..891	CDD:254352	25/100 (25%)
		Ig_Titin_like	822..894	CDD:143225	19/80 (24%)
		FN3	898..981	CDD:238020	18/82 (22%)
		I-set	1013..1102	CDD:254352	9/46 (20%)
		Ig	1032..1097	CDD:143165	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000