DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and CNTN5

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001230199.1	Gene:	CNTN5 / 53942	HGNCID:	2175	Length:	1100	Species:	Homo sapiens

Alignment Length:	1127	Identity:	237/1127 - (21%)
Similarity:	387/1127 - (34%)	Gaps:	337/1127 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 VELMCRSRGGNPPAQLIWYKNGSQIRMA--YRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQ 365
            |.|.|..| |||.....|.:||::|.:.  ||.|......|.:..:||.|: ..::|.|:|.:.
Human   119 VALNCEVR-GNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDS-GHYQCLATNTVG- 180

  Fly   366 NPLKAEVELSVLFAPTHVTVMGPTEA----RVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRN--- 423
            :.|..|..|...:..   ...|.|.:    |.|..|.|.|:..|.:|.....|      |.|
Human   181 SILSREATLQFAYLG---NFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSW------VFNEFP 236

  Fly   424 ----ATSKTIVSPEGG-----WTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYP 479
                ..|:..:|.|.|     ...||::.:          .||      |.:|.|:  ...||.|
Human   237 SFVAEDSRRFISQETGNLYISKVQTSDVGS----------YIC------LVKNTVT--NARVLSP 283

  Fly   480 PAP-------------PLISGYMEGQIIPA-GSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRA 530
            |.|             |.|..:....:..| |:..|:.|.:. |||:.|:||.|.:..|.|..|.
Human   284 PTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFAL-GNPVPTITWMKVNGYIPSKARL 347

  Fly   531 ADKSVSAEITILANVS-DNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGME 594
            .......||   .||. |:...|.|.|.||
Human   348 RKSQAVLEI---PNVQLDDAGIYECRAENS----------------------------------- 374

  Fly   595 ATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN 659
                                     .|.|:               ||..:      ||||
Human   375 -------------------------RGKNS---------------FRGQL------QVYT----- 388

  Fly   660 EALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDG 724
                             .|.:|...:.|.:. .|..|:...:....|.| ||:|.|:|  :|...
Human   389 -----------------YPHWVEKLNDTQLD-SGSPLRWECKATGKPRP-TYRWLKNG--VPLSP 432

  Fly   725 DHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGG--ATLNITVVVEYGT-TIKSVSENIVVNPGE 786
            ..|:....|.|....:::.|||:|.|.|.|..|.  |:..:.::....| .:..:.:.|:|...:
Human   433 QSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQ 497

  Fly   787 DAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFA---NGTSYLHIKDAKREDVGNFRCVADNR 848
            :.::.|..:|.|  :..:.|::  .|..|:.:...|   :|:  |.|.:|.:.|.|.:.|..:|.
Human   498 EVVIECKPQGSP--KPTISWKK--GDRAVRENKRIAILPDGS--LRILNASKSDEGKYVCRGENV 556

  Fly   849 VDNPTNRDIL--LIVKFAPEIAKTPTLLRAASGTGERGRLPCRA--QGSPKPQFIWRQDKKDLPI 909
            ..   :.:|:  |.||....|..||.  |.....||...|.|:|  ..|....|.|  ..|..||
Human   557 FG---SAEIIASLSVKEPTRIELTPK--RTELTVGESIVLNCKAIHDASLDVTFYW--TLKGQPI 614

  Fly   910 NRTYKYEVEERKIDSLTYEST---LIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPL 971
            :    :|.|....:|:..:::   |::..:.....|.|.|..:.......:...|.:...|.||.
Human   615 D----FEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPG 675

  Fly   972 SLNILNVTHDTVTLAWTPGFDGGLK-ASYRVRYRMADREQYKYIDGLPNSHKLTIGGLR------ 1029
            .:.:..:|..|.||:|:|..|.... :||.::.|......::.:..:|   ::..|.:.
Human   676 IVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVP---EIITGDMESAMAVD 737

  Fly  1030 MN--TLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSL--GGGPPTTSQTPLGGTSGM- 1089
            :|  ..|.|.|::.|.:|...               ||.|:..:  ....|.|:.|.:.|.||.
Human   738 LNPWVEYEFRVVATNPIGTGD---------------PSTPSRMIRTNEAVPKTAPTNVSGRSGRR 787

  Fly  1090 --LLV-----------GVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTE----DSS- 1136
              |::           |.|.|.:|..           :.|..|..:...:..:|.::    |.|
Human   788 HELVIAWEPVSEEFQNGEGFGYIVAF-----------RPNGTRGWKEKMVTSSEASKFIYRDESV 841

  Fly  1137 --NTPNLVIIGI----SLAAFGFLLVNAS----------------------LVAWFFVHQRRKKV 1173
              .||..|.:|:    ....|..::|..|                      ||||       |.:
Human   842 PPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAW-------KHI 899

  Fly  1174 AETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKS-----------------ESYSNEGSSQP 1221
            .|:..:| :...:..:......|  |.||:.:...:|                 .:|:..|...|
Human   900 KESLGRP-QGFEVGYWKDMEQED--TAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPP 961

  Fly  1222 EYIDEVRKKAASTYLVEGSDMPPP-RYQKDGT---------LPVIYPNNVVNACTLPHPRHNNGS 1276
            .  .||   :|:|.....|..|.. |:::.|:         :|:...:.||..........::.|
Human   962 S--SEV---SATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNS 1021

  Fly  1277 AAIHMTRDDQMLI---SKGVYI 1295
            ..|. |:..|.::   ..||||
Human  1022 QVIE-TQKLQAVVPLPDAGVYI 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	24/74 (32%)
		Ig	300..361	CDD:299845	20/59 (34%)
		Ig	380..454	CDD:299845	18/89 (20%)
		IG_like	490..573	CDD:214653	24/84 (29%)
		Ig	501..560	CDD:299845	21/59 (36%)
		Ig	584..666	CDD:299845	8/81 (10%)
		IG_like	585..666	CDD:214653	8/80 (10%)
		I-set	678..767	CDD:254352	25/90 (28%)
		IGc2	692..757	CDD:197706	20/64 (31%)
		Ig	788..849	CDD:143165	15/63 (24%)
		Ig	885..960	CDD:143165	16/79 (20%)
		FN3	967..1051	CDD:238020	21/92 (23%)
CNTN5	NP_001230199.1	Ig1_Contactin-5	98..191	CDD:143256	24/74 (32%)
		I-set	99..190	CDD:254352	23/73 (32%)
		Ig	193..287	CDD:299845	27/120 (23%)
		IG_like	205..278	CDD:214653	21/96 (22%)
		Ig	300..387	CDD:299845	31/171 (18%)
		I-set	300..386	CDD:254352	30/170 (18%)
		I-set	390..475	CDD:254352	25/88 (28%)
		Ig	392..475	CDD:299845	24/86 (28%)
		I-set	489..568	CDD:254352	19/87 (22%)
		Ig5_Contactin_like	496..568	CDD:143170	17/80 (21%)
		I-set	573..667	CDD:254352	23/101 (23%)
		Ig	587..671	CDD:299845	18/89 (20%)
		FN3	671..768	CDD:238020	24/114 (21%)
		FN3	776..868	CDD:238020	19/102 (19%)
		FN3	878..969	CDD:238020	18/105 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..982		7/27 (26%)
		FN3	977..1062	CDD:238020	14/67 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910