DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and zgc:113337

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001013337.1	Gene:	zgc:113337 / 503741	ZFINID:	ZDB-GENE-050306-20	Length:	371	Species:	Danio rerio

Alignment Length:	314	Identity:	59/314 - (18%)
Similarity:	106/314 - (33%)	Gaps:	95/314 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 FVPPP---SSTAVGVEGESL-QVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFA----DGGSLN 736
            ||..|   |.|.|...|||: |:......|.|.::|:..:..:...|  .|...|    |..::.
Zfish    18 FVEQPFTLSCTLVKARGESVHQIRWLDVQNQTLISYQPGQQDSVSGQ--QHVELAASPRDASAIT 80

  Fly   737 FTRLHRDDAGIYSC-------SASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTV 794
            ..|:...|.|.|:|       .:...|...|:..||:.|..||...         |:...|:|..
Zfish    81 IKRVSHRDEGCYTCIFDILPKGSREGQTCLTVTATVIPEGNTTAVG---------GKQITLACRY 136

  Fly   795 EGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILL 859
             |.|...:.|.|:::                    :..|:..::..|...:|..::    .:.:.
Zfish   137 -GLPEKVKQVLWKKI--------------------VTKAESREIAFFAKQSDPVIE----EEFVE 176

  Fly   860 IVKFAPEIAKT----------------------PTLLRAASGTGERGRLP--------------- 887
            .|..:|.::.|                      |.::::|:.......||
Zfish   177 RVSLSPSLSDTQLTLWPVQSEDEACYTCEFHTYPDVIKSATSCLTVFVLPKPQVSYKTTSPGVIE 241

  Fly   888 --CRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERK-----IDSLTYESTLIVD 934
              |.|...||.:.:|..:..|..|......:|::..     |.:||.::.|:.|
Zfish   242 ANCTAVARPKAEIVWNVEGNDRTIGPPVTIDVQQSDGTTLVISTLTIQAGLLKD 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	26/101 (26%)
		IGc2	692..757	CDD:197706	16/76 (21%)
		Ig	788..849	CDD:143165	9/60 (15%)
		Ig	885..960	CDD:143165	15/72 (21%)
		FN3	967..1051	CDD:238020
zgc:113337	NP_001013337.1	IG_like	12..112	CDD:214653	23/95 (24%)
		Ig	21..112	CDD:299845	21/92 (23%)
		IG_like	120..222	CDD:214653	17/135 (13%)
		Ig1_MRC-OX-2_like	127..223	CDD:143254	15/120 (13%)
		Ig	<250..316	CDD:299845	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910