DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and pxdn

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_001076815.1 Gene:pxdn / 493201 XenbaseID:XB-GENE-923300 Length:1460 Species:Xenopus tropicalis


Alignment Length:1164 Identity:247/1164 - (21%)
Similarity:398/1164 - (34%) Gaps:335/1164 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   469 VSTHTINVLYPPAPPLISGYMEGQIIPA--GSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAA 531
            |||.|.:.|....|.:.|   |.|.:..  |:.....| .:.|||...:.|.:|:..::....:.
 Frog   226 VSTITPSELNCERPRITS---EPQDVDVTFGNTVYFTC-RAEGNPKPEIIWLRNNNELSMKDDSR 286

  Fly   532 DKSVSAEITILANVSD-NQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPE--ELRPGM 593
            ...::....::.|..: :|..|:|.|.|.|.|:...: .||..:..|.|....|:|:  |:..|.
 Frog   287 LNLLNDGTLMIQNTKETDQGIYQCMAKNVAGEVKTHE-VTLRYYGTPATPTFVIQPQNTEVLVGE 350

  Fly   594 EATIICDSSSSNPPAKLSWWK-DGIPIEG---INNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYT 654
            ..|:.| |::..|..:::|.: |..|:..   ||.|...||         :..||.|:..|: ||
 Frog   351 SVTLEC-SATGQPHPRVTWTRGDRTPLPSDPRINITPSGGL---------YIQNVNQDDAGE-YT 404

  Fly   655 CQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTT 719
            |.:.|..  .:.|....:.|...|:|...|....| .||.::....:.:.||.|| ..|||.|..
 Frog   405 CFATNSV--ETIHSTAYIIVQAVPQFTVVPQDRNV-FEGHTVDFHCEAQGNPKPV-IAWTKGGNQ 465

  Fly   720 IPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTT--IKSVSENIVV 782
            :..|..|::.: .|:|...|:...|.|.|.|.|.|..|..:....::|:...|  ..:|..::.|
 Frog   466 LSVDRRHQVLS-SGTLRILRVALHDQGQYECQAVNIVGSKSTAAQLIVQTRVTPVFATVPNDMTV 529

  Fly   783 NPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADN 847
            ..|.|..:.|:.:|.||  ..:.|.:.|..:| ::.....:...||.|:||...|.|.:.|||.|
 Frog   530 EVGTDVQIPCSSQGDPL--PIITWNKDGIQVT-ESGKFHISPHGYLAIRDAGLADQGRYECVARN 591

  Fly   848 RVDNPTNRDILLIVKFAPEIAKT-------------PTLLRAASGTGERGRLPCRAQGSPKPQF- 898
            .:...:...:|.::  .||:::|             .|:.||.:.|  |..|......||.... 
 Frog   592 PIGYSSVSMVLSVL--VPEVSRTGDPFVATSIIEAIATVDRAINST--RTHLFDSRPRSPGDLLA 652

  Fly   899 IWRQDKKDLPINRTYKYEVEERKIDSLT--YESTLIV----------DKVAPADYGAYECVARNE 951
            ::|..:....:.:....|:.||.:..:.  .:|.|:|          |.|:|    .|..:..|.
 Frog   653 LFRYPRDPYTVEQARAAEIFERTLQLIQDHVQSGLMVDLNGTSYHYNDLVSP----QYLNMIANL 713

  Fly   952 LGEAVETVRLEITSQPDPPLSLNILNV-------THD-TVTLAWTP-------GFDGGLKASYRV 1001
            .|.|... |:.           |..|:       ||| |......|       .|:..||:.|..
 Frog   714 SGCATHR-RIN-----------NCSNMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYEN 766

  Fly  1002 RYRMADREQYKYIDGLP------------NSHKLTIGGLRMNTLYLFSVMSWNE----------- 1043
            .:.:......:..:|.|            .:|.:|     .:..:...:|.|.:           
 Frog   767 GFNLPRGISGRIYNGFPLPLPRLVSTTLIGTHTIT-----PDEQFTHMLMQWGQFLDHDLDSTVV 826

  Fly  1044 -LGQSSYL--PDLARAETKEAP------PPSHP-------ASSLGGGPPTTSQTPLGGTSGMLLV 1092
             |.|:.:.  .|.:...|.:||      ||:.|       ..|:....|.               
 Frog   827 ALSQARFSDGQDCSVVCTNDAPCFPIMVPPNDPRVRNNARCMSMVRSSPV--------------- 876

  Fly  1093 GVGAGIVVVLLN-VF----------------VIGCCLHKRNEKR--------LKRGL------EL 1126
             .|:|:..:|:| |:                |.|...|:.||.|        ||:|:      .|
 Frog   877 -CGSGMTSLLMNSVYPREQMNQLTSYIDASNVYGSSDHESNEIRDSASHRGLLKQGIVQRSGKPL 940

  Fly  1127 M------PAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTAT 1185
            :      |.|...|.:.:|....:.....|...|.:.:....||..|.|           ..|..
 Frog   941 LPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNR-----------IATEL 994

  Fly  1186 IEMYAPSSYNDTVTGETLSSVSEKSE--SYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQ 1248
            :.: .|....||:..||...|..:.:  :||:   ..|:...:|..|....|         ..|.
 Frog   995 LRL-NPHWDGDTIYHETRKIVGAQMQHITYSH---WLPKIFGDVGMKMLGEY---------KSYD 1046

  Fly  1249 KDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNS 1313
                     ||  |||..|    :...:||.   |....||:..:|                   
 Frog  1047 ---------PN--VNAGIL----NEFATAAF---RFGHTLINPILY------------------- 1074

  Fly  1314 DRYLSYPPMEYPAALDFTAQPMPMAHL-------QPMTVTSLATNGG--PTLIGNGSVAAVAGGS 1369
                         .||...:|:|..|:       .|..:.:   .||  |.|.|...|||....:
 Frog  1075 -------------RLDEKFEPIPQGHVPLHRAFFSPFRIVN---EGGIDPLLRGLIGVAAKMRVT 1123

  Fly  1370 GTL-------------------------RRGILRGVV----------------------GVPQPD 1387
            ..|                         :||...|:.                      .:..||
 Frog  1124 SQLLNTELTEKLFSMAHAVALDLAALNVQRGRDHGIPPYHDFRVFCNLSTVQTFDDLRNEIKNPD 1188

  Fly  1388 VTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSLPTATATLPRQPHGILKDPNR 1446
            |......:.|||:.:  ||.|. |....|...:.|.   ||....|..|...| :|.:|
 Frog  1189 VREKLKRLYGSPLNI--DLFPA-LMVEDLIPGSRLG---PTLMCLLTTQFRNI-RDGDR 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653
Ig 197..279 CDD:299845
IG_like 296..376 CDD:214653
Ig 300..361 CDD:299845
Ig 380..454 CDD:299845
IG_like 490..573 CDD:214653 19/85 (22%)
Ig 501..560 CDD:299845 12/59 (20%)
Ig 584..666 CDD:299845 24/87 (28%)
IG_like 585..666 CDD:214653 23/86 (27%)
I-set 678..767 CDD:254352 26/88 (30%)
IGc2 692..757 CDD:197706 21/64 (33%)
Ig 788..849 CDD:143165 18/60 (30%)
Ig 885..960 CDD:143165 17/87 (20%)
FN3 967..1051 CDD:238020 19/124 (15%)
pxdnNP_001076815.1 leucine-rich repeat 38..56 CDD:275380
LRR <54..235 CDD:227223 4/8 (50%)
leucine-rich repeat 57..80 CDD:275380
LRR_8 104..163 CDD:338972
leucine-rich repeat 105..128 CDD:275378
leucine-rich repeat 129..152 CDD:275378
leucine-rich repeat 153..176 CDD:275378
leucine-rich repeat 177..189 CDD:275378
I-set 239..326 CDD:369462 19/91 (21%)
I-set 335..422 CDD:369462 25/99 (25%)
Ig3_Peroxidasin 439..512 CDD:143222 22/74 (30%)
Ig4_Peroxidasin 535..603 CDD:143223 18/70 (26%)
peroxidasin_like 856..1295 CDD:188658 92/485 (19%)
VWC 1402..1452 CDD:214564
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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