DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and NCAM1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	923	Identity:	203/923 - (21%)
Similarity:	322/923 - (34%)	Gaps:	251/923 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 MEGQIIPA------GSVQKLLCVSSGGNPLATLTWYK--------NDKRINSVIRAADKSVSAEI 539
            ::..|:|:      |..:..||..:|......::|:.        |.:|| ||:...|.  |:.:
Human    20 LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRI-SVVWNDDS--SSTL 81

  Fly   540 TIL-ANVSDNQAQYRC-------EASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEAT 596
            ||. ||: |:...|:|       ..|.:...:.:||.  |....||       .|:|.|.|.:|.
Human    82 TIYNANI-DDAGIYKCVVTGEDGSESEATVNVKIFQK--LMFKNAP-------TPQEFREGEDAV 136

  Fly   597 IICDSSSSNPPAKLSWWK-------------------DGIPIEGINNTSKPGLWGGTVSTLEFRV 642
            |:||..||.||..:  ||                   :.:.|.||..|.:     ||
Human   137 IVCDVVSSLPPTII--WKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDE-----GT-------- 186

  Fly   643 NVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSS------TAVGVEGESLQVSLQ 701
                      |.|:  ...|.|.......:.|:..   |||...      .|....|:|:.:...
Human   187 ----------YRCE--GRILARGEINFKDIQVIVN---VPPTIQARQNIVNATANLGQSVTLVCD 236

  Fly   702 TRANPTPVTYKWTKDGTTIPQDGDHR--IFADGGS-LNFTRLHRDDAGIYSCSASNSQG--GATL 761
            ....|.| |..|||||..|.|:.|..  ||:|..| |...::.::|...|.|.|.|..|  .||:
Human   237 AEGFPEP-TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATI 300

  Fly   762 NITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPL-------------TEEHVKWER----- 808
            ::.|..:  ..|..|.....:...|...|:|...|.|:             :||...|.|
Human   301 HLKVFAK--PKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQE 363

  Fly   809 --------VGYDMTVKTSTTFANG---------------TSYLHIKDAKREDVGNFRCVADNRVD 850
                    ||.......|..|...               .|.|.:|..:..|.|.:.|.|.|.:
Human   364 VHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTI- 427

  Fly   851 NPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKY 915
            ...::.:.|.|::||:: :.|  :...:..|.:..:.|.....|.....|.:|.:.||.:
Human   428 GQDSQSMYLEVQYAPKL-QGP--VAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSS----- 484

  Fly   916 EVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG-EAVETVRLEITSQPDPPLSLNILNVT 979
            .....||.:....|.|.|...:..|:|.|.|.|.|.:| |::|.:.:    |.|.|.|.:|..|.
Human   485 NYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILV----QADTPSSPSIDQVE 545

  Fly   980 --HDTVTLAW-TPGFDGGLK-ASYRVRYRMADREQY--KYIDGLPNSHK--LTIGGLRMNTLYLF 1036
              ..|..:.: .|...||:. ..|:..:|....|.:  |:.|....|.:  :||.||:..|.|..
Human   546 PYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAV 610

  Fly  1037 SVMSWN--ELGQSSYLPDLARAETKEAPPPSHPAS-----SLG---------------GGPP--- 1076
            .:.:.|  .||:.|     |.:|.|..|....|::     .:|               ||.|
Human   611 RLAALNGKGLGEIS-----AASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRH 670

  Fly  1077 --------TTSQTPLGGTSGMLLVGVGAGIVVVLL---------NVFVIGCCLHKRNEKRLKRGL 1124
                    ::...|        .:.:.:|...|:|         .|:|:.     .|::...:..
Human   671 YLVRYRALSSEWKP--------EIRLPSGSDHVMLKSLDWNAEYEVYVVA-----ENQQGKSKAA 722

  Fly  1125 ELM------PAELTEDSSNTPNL---VIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQP 1180
            ..:      |..:..:.|.|..|   .|:||.:..|..|||...:..:|.
Human   723 HFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLVVVDITCYFL--------------- 772

  Fly  1181 AKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPP 1245
            .|.......|.:.......|.....:.|...::|.:.|.:|  |.|||.:...|...:|.....|
Human   773 NKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEP--IVEVRTEEERTPNHDGGKHTEP 835

  Fly  1246 RYQKDGTLPVIYP 1258
                :.|.|:..|
Human   836 ----NETTPLTEP 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	25/104 (24%)
		Ig	501..560	CDD:299845	19/74 (26%)
		Ig	584..666	CDD:299845	24/100 (24%)
		IG_like	585..666	CDD:214653	24/99 (24%)
		I-set	678..767	CDD:254352	31/99 (31%)
		IGc2	692..757	CDD:197706	23/67 (34%)
		Ig	788..849	CDD:143165	20/101 (20%)
		Ig	885..960	CDD:143165	20/75 (27%)
		FN3	967..1051	CDD:238020	25/93 (27%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	22/98 (22%)
		IG	124..190	CDD:214652	22/97 (23%)
		Ig	211..307	CDD:325142	30/96 (31%)
		Ig	306..438	CDD:325142	24/134 (18%)
		Ig_3	447..519	CDD:316449	18/78 (23%)
		FN3	534..631	CDD:238020	27/101 (27%)
		fn3	639..720	CDD:306538	11/93 (12%)
		Trypan_PARP	<792..>864	CDD:330686	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910