DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and hbs

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1337	Identity:	635/1337 - (47%)
Similarity:	835/1337 - (62%)	Gaps:	158/1337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QHWIKHLQLLRLLAVI--VLASAPVPSHAQQ------QKFRTTPHDLQVLEGAEAMMRCEVANVA 99
            |.||.....:.|...|  |:|:...|:.|.|      |||..||||||:|||.:.::||||:|.|
  Fly     2 QFWITLTFAVHLATTICHVMAAVTAPTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEVSNRA 66

  Fly   100 GAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRA 164
            |.|||||||||||||||||||||||||.|.||..|||:|.||::.|||:||||||||..|.||||
  Fly    67 GKVQWTKDGFALGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQVGPAAGNPAIRA 131

  Fly   165 NAKLTVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKRED-- 227
            ||||::::.|:||.|:||:.|::|||.|.|:|.|.||..||.|||:|||::|.|   |.....
  Fly   132 NAKLSIVAAPSSIVIEGYARNARVEVEERQNLTLHCIAENANPAAEIVWFQGEV---PVSTAPIV 193

  Fly   228 TVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYS 292
            ||.::..|||||:|:|.|:|..:|||.|::|:||||||.||:||||.||||||||||.|:.||||
  Fly   194 TVNQTAPKRFTTSSTLHLQPRAEDDYKEFSCEARHKALPPDVPMRAQVQLSVLYPPGAPFFEGYS 258

  Fly   293 AGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRC 357
            .||||.|||.|::.||||||||||||.||:||..|....|||||||||:|.|||.|.||.|...|
  Fly   259 QGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQRTSGRLSENVYKFTAAAEDNGANLVC 323

  Fly   358 EASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVR 422
            ||.|:::..||:||:.|:||:||..|.:.|..:|:|||.|.|:|.||||||.|.|.|.:.||.:.
  Fly   324 EAKNLLATTPLRAELNLTVLYAPKDVYLSGANQAKVGDSVQLSCVTAPSNPQARISWSINGRPLD 388

  Fly   423 NATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISG 487
            |:|.||..|.:|||.::|||:..::...|:.:.:||.||.:||:|||.:||:||||||:|||::|
  Fly   389 NSTYKTTSSSDGGWVSSSNISLTIDSQSRTFIAVCHALNTELTQNVVGSHTVNVLYPPSPPLLTG 453

  Fly   488 YMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQY 552
            |.:|.|:.:||:.||.|.|:||||..||.||||||.||:..:..|..:::|:::|.|.|||.|.|
  Fly   454 YNDGDILISGSILKLQCSSAGGNPPPTLQWYKNDKIINAPSKLVDSKITSELSLLVNASDNNAIY 518

  Fly   553 RCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGI 617
            :|:..|:|.:||||.:.||.|||.||||||.:.|:.|.||:.|.:||||||||||||:|||||||
  Fly   519 KCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGI 583

  Fly   618 PIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVP 682
            |:||:|..::||||||:|||||..||:||:::|.||||||.||.||||.||.:|||:||.|||..
  Fly   584 PVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPPKFET 648

  Fly   683 PPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQD--GDHRIFADGGSLNFTRLHRDDA 745
            |.|:|.|||||....|.|....||..:||.|||||..|..:  ...|:.:||..||.:||.|:||
  Fly   649 PQSTTFVGVEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDA 713

  Fly   746 GIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVG 810
            |:|.|.|.||||.|.|.|.|.|||..||.:|||......||.|:|:|.::.:||...||:|.|.|
  Fly   714 GVYICEALNSQGTALLEIQVAVEYAPTITAVSEGRSFVAGEPAVLACHIQARPLEAAHVRWSRDG 778

  Fly   811 YDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLR 875
            ||:..:|.::|.|||:.|.|...:|.|:|||.|:.||:...|..:::||:|:.||||..:|...|
  Fly   779 YDLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTR 843

  Fly   876 AASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPAD 940
            .|:..|.|.:|.||:..||:|.||||:..|||.:.|..|::..||::|:|.:||.|:::..:|.|
  Fly   844 YAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDD 908

  Fly   941 YGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRM 1005
            ||.||||.||.||:|..|:.....|:||.||.|.:.||:...|.|.||||||||::..:|:|.:.
  Fly   909 YGQYECVVRNSLGQASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFRLRLKQ 973

  Fly  1006 ADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASS 1070
            ...::|||:|..|....:::.||:....|.||||:.||.|.|.::||:....:|.:.|.|
  Fly   974 HGEDKYKYVDAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQPHS----- 1033

  Fly  1071 LGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDS 1135
                                                                      ||.|| .
  Fly  1034 ----------------------------------------------------------AEYTE-K 1039

  Fly  1136 SNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTG 1200
            ...||::||||:.||...|::||:|||||.:.::.|..:|.             .||  ||.|
  Fly  1040 DELPNVMIIGITSAAMVLLVLNAALVAWFVIRRQNKSQSEA-------------EPS--NDDV-- 1087

  Fly  1201 ETLSSVSEKSESYSNEGSSQPEY--------IDEVRKKAASTYLVEGSDM-----PPPRYQKDGT 1252
                        ||.: .||..|        .|..:|.||||||||..|:     .||:||:...
  Fly  1088 ------------YSKD-DSQSVYKLPITALQADVQKKAAASTYLVENVDIIQSTAYPPKYQESSM 1139

  Fly  1253 LPVIYPNNVVNAC------TLPHP-RHNNGSAAIHM-------TRDDQMLISKGVYIP------- 1296
            ....||     .|      |||:| ||:..::|..|       ::||.||||.|:|||
  Fly  1140 CTPPYP-----LCNPDFTRTLPNPKRHSQRNSATGMIEGMQMRSKDDHMLISNGLYIPSPSPASS 1199

  Fly  1297 ---------SPSPAPPPDGSYYNMNSDRYLSYPPMEY 1324
                     |||||||.||||:|| ||:|:||||:.|
  Fly  1200 LVIKGSYISSPSPAPPADGSYFNM-SDKYMSYPPVTY 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	72/96 (75%)
		Ig	76..155	CDD:299845	58/78 (74%)
		IG_like	186..279	CDD:214653	51/94 (54%)
		Ig	197..279	CDD:299845	45/83 (54%)
		IG_like	296..376	CDD:214653	49/79 (62%)
		Ig	300..361	CDD:299845	40/60 (67%)
		Ig	380..454	CDD:299845	33/73 (45%)
		IG_like	490..573	CDD:214653	40/82 (49%)
		Ig	501..560	CDD:299845	29/58 (50%)
		Ig	584..666	CDD:299845	55/81 (68%)
		IG_like	585..666	CDD:214653	55/80 (69%)
		I-set	678..767	CDD:254352	45/90 (50%)
		IGc2	692..757	CDD:197706	30/66 (45%)
		Ig	788..849	CDD:143165	27/60 (45%)
		Ig	885..960	CDD:143165	36/74 (49%)
		FN3	967..1051	CDD:238020	35/83 (42%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845	58/77 (75%)
		IG_like	45..137	CDD:214653	69/91 (76%)
		Ig	153..231	CDD:299845	40/80 (50%)
		IG_like	258..342	CDD:214653	52/83 (63%)
		Ig	266..327	CDD:299845	40/60 (67%)
		IG_like	357..>414	CDD:214653	29/56 (52%)
		Ig	360..427	CDD:299845	30/66 (45%)
		Ig	<468..526	CDD:299845	28/57 (49%)
		I-set	547..633	CDD:254352	58/85 (68%)
		Ig	556..631	CDD:299845	52/74 (70%)
		I-set	644..735	CDD:254352	45/90 (50%)
		IGc2	668..725	CDD:197706	26/56 (46%)
		IG_like	751..829	CDD:214653	32/77 (42%)
		IGc2	753..815	CDD:197706	27/61 (44%)
		Ig	852..928	CDD:143165	36/75 (48%)
		FN3	935..1017	CDD:238020	35/81 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443436
Domainoid	1	1.000	94	1.000	Domainoid score	I7422
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1173
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0005450
OrthoInspector	1	1.000	-	-		otm26237
orthoMCL	1	0.900	-	-		OOG6_107508
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
	11	10.800