DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and side-III

DIOPT Version :10

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_001036681.1 Gene:side-III / 4379844 FlyBaseID:FBgn0083949 Length:1689 Species:Drosophila melanogaster


Alignment Length:1269 Identity:239/1269 - (18%)
Similarity:401/1269 - (31%) Gaps:456/1269 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 EARVGDIVPLTCTTAPSNPPAE---IKWM------------VGGRQVRNATSKTIVSPEGGWTTT 439
            ||.:|....|.|...|......   :.|.            |.||....|..         |:.|
  Fly    60 EAVLGRTASLPCDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALY---------WSDT 115

  Fly   440 SN-------ITAVVEPNKRSLVVICHGLNMQLTENVV------------STHTIN--VLYPPAPP 483
            ::       :|. .:|.|.|:.      |:||.:..|            ..|.||  |:.||...
  Fly   116 NSFGPRAYFVTG-QQPAKLSVD------NIQLDDEGVYRCRVDFQNSPTRNHRINLTVIVPPHQI 173

  Fly   484 LISGYMEGQIIPAGSVQKLL--------CVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEIT 540
            |:.. ..|:.: ||:|..||        |...||.|..|:||....:.:.:   .:..|:...:|
  Fly   174 LVYD-ASGRDV-AGAVGPLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEA---GSGVSMGRHVT 233

  Fly   541 I----LANVSDNQAQ--YRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIIC 599
            :    :|.:|.:...  |||:|||:....|:.:|..:.:...|.:|.:..:.:......:..:.|
  Fly   234 VNRLEVAQISRSALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTC 298

  Fly   600 DSSSSNPPAKLSWWKDGIPIE-GINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQ 663
            ..:.|.|..::.|.::..|.: |:.:||:..  |..:|||.|...  .|.:|.:..|:.:|..||
  Fly   299 IVAGSVPDTEIKWTQNNRPFKRGLLSTSQSN--GRVISTLTFYPQ--PEDDGTMLKCEGSNPRLQ 359

  Fly   664 RSA-HEAVSLDVLYRPKFVPPPSSTAVG--------VEGESLQVSLQTRANPTPVTYKWTKDGTT 719
            .|| .:::.::|:|     ||..:.::|        .||:.:......::||......|:.||..
  Fly   360 NSAIEDSLMMNVIY-----PPQVTLSLGSTLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQP 419

  Fly   720 IPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQG---GATLNITVVVEYGTTIKSVSENIV 781
            :.|:....|.....||...|:.|..:|.|:|||:|.:|   .|.:|:.  :.|.....|.|..::
  Fly   420 VTQNVSWGIIISTRSLVLQRVGRIHSGFYACSAANDRGETQSAPVNLR--IRYAPVCSSSSITVI 482

  Fly   782 -VNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVA 845
             .:..||..:.|.|...| .|...:|             ||:....:..:..      |::..:.
  Fly   483 GASLEEDVPIPCRVNSDP-PEIDFEW-------------TFSTSGEHFEVPS------GHYATIQ 527

  Fly   846 DNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPIN 910
            |                        ||:...:.                              :.
  Fly   528 D------------------------PTMTTTSD------------------------------VR 538

  Fly   911 RTYKYEVEERKIDSLTYEST---LIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLS 972
            ||.   ||..:....:|..|   ||.......|||...|..||.:|:..:....::.....|   
  Fly   539 RTV---VESNETHFESYVETVSELIYTPKGERDYGTLACYGRNAIGKQSDPCVFQVVPAAKP--- 597

  Fly   973 LNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFS 1037
                                                                 |.||..||..:.
  Fly   598 -----------------------------------------------------GALRNCTLRPYV 609

  Fly  1038 VMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVL 1102
            |.|                            :||.....||                        
  Fly   610 VTS----------------------------ASLNSSNQTT------------------------ 622

  Fly  1103 LNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVII------------GISLAAFGFLL 1155
                     :|..         :::|.:.....||.|::..:            |.:.||....:
  Fly   623 ---------MHAN---------QILPTQYGRHESNYPHMEYVRERHNSSGGNNNGTAPAAGRNNV 669

  Fly  1156 VNASLVAWFFVHQRR---KKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEG 1217
            .|.::.......|.:   |::.:...|..|..|  .:.||        :||:::..:.:  ..:.
  Fly   670 ANKNMRGRTSAGQAKSNNKQLTQQQLQRLKKRT--SFTPS--------QTLAAIERQRQ--RKQL 722

  Fly  1218 SSQPEYIDEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNACTLP-------------H 1269
            |.|.:.:.:...:|.:|  ..|.|..|     ||:........:..|...|             |
  Fly   723 SQQQQQLQQQHHQATAT--KSGGDNKP-----DGSPAKSSKQRMRRASRDPQIQQQQQHQQQQQH 780

  Fly  1270 PRHNNGSAAIHMTRDDQML---------ISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYP 1325
            ..|    ||..:|...:..         :.||    |.|.:.....|..|:||.......|.:| 
  Fly   781 QLH----AATSITSSQRKQAESNLSTSHLGKG----SSSSSRSRRSSSSNINSKSNNGKQPAKY- 836

  Fly  1326 AALDFTAQPMPM---AHLQPMTVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGVPQPD 1387
                |..:...|   .|.|.:..                               |:|.......:
  Fly   837 ----FNKRQKNMHKQKHQQKLKQ-------------------------------LKGTTNEHNSN 866

  Fly  1388 VTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSLP----------TATATL--------- 1433
            :.||.:.:..| ::....|...::.|:....||:.:.|.|          ||||.:         
  Fly   867 IIHHYAALSSS-LRRRKRLAANDILATVAAASTSASLSSPPASSAASLAATATAAVEIEQDVSAV 930

  Fly  1434 --PRQPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQILNLPPA 1496
              |....|     :.||:.::......:|:|.|.|||||         |.:||    ||.|.|.|
  Fly   931 DAPAADSG-----SNNKRSRKSLTILDKQKQQQEQQQLL---------PPNAP----QISNQPVA 977

  Fly  1497 SGGLGNNLLMTTNAFDPTTVGLSSFGAVSQAGGI 1530
            :.. |||:        ..|...|:.|||  |.|:
  Fly   978 AIS-GNNV--------KETAATSAHGAV--AAGV 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 Ig 73..170 CDD:472250
Ig strand B 89..93 CDD:409559
Ig strand C 101..105 CDD:409559
Ig strand E 130..138 CDD:409559
Ig strand F 148..153 CDD:409559
Ig 173..279 CDD:472250
Ig strand B 196..200 CDD:409418
Ig strand C 210..214 CDD:409418
Ig strand E 241..245 CDD:409418
Ig strand F 255..260 CDD:409418
Ig strand G 272..275 CDD:409418
Ig_3 285..361 CDD:464046
Ig 377..>457 CDD:472250 17/88 (19%)
Ig strand B 397..401 CDD:409418 1/3 (33%)
Ig strand C 411..415 CDD:409418 0/6 (0%)
Ig strand E 440..444 CDD:409418 0/10 (0%)
Ig 477..560 CDD:472250 26/96 (27%)
Ig strand B 499..504 CDD:409418 3/12 (25%)
Ig strand C 514..518 CDD:409418 2/3 (67%)
Ig strand E 537..541 CDD:409418 0/3 (0%)
Ig strand F 551..556 CDD:409418 3/6 (50%)
Ig 584..666 CDD:472250 19/82 (23%)
Ig strand B 595..599 CDD:409416 0/3 (0%)
Ig strand C 609..613 CDD:409416 0/3 (0%)
Ig strand E 636..642 CDD:409416 4/5 (80%)
Ig strand F 652..657 CDD:409416 1/4 (25%)
Ig strand G 667..670 CDD:409416 0/2 (0%)
Ig 678..767 CDD:472250 25/99 (25%)
Ig strand B 696..700 CDD:409353 0/3 (0%)
Ig strand C 710..714 CDD:409353 0/3 (0%)
Ig strand E 733..737 CDD:409353 2/3 (67%)
Ig strand F 747..752 CDD:409353 2/4 (50%)
Ig_3 772..847 CDD:464046 12/75 (16%)
Ig 881..963 CDD:472250 15/84 (18%)
Ig strand B 885..888 CDD:409353 0/2 (0%)
Ig strand C 897..901 CDD:409353 0/3 (0%)
Ig strand E 929..933 CDD:409353 2/6 (33%)
Ig strand F 943..948 CDD:409353 1/4 (25%)
FN3 967..1051 CDD:238020 8/83 (10%)
side-IIINP_001036681.1 V-set 59..166 CDD:462230 24/121 (20%)
Ig_3 190..257 CDD:464046 17/69 (25%)
Ig 289..359 CDD:472250 17/73 (23%)
Ig strand C 308..312 CDD:409468 0/3 (0%)
Ig strand E 335..338 CDD:409468 2/2 (100%)
Ig strand F 348..353 CDD:409468 1/4 (25%)
Ig_3 374..454 CDD:464046 21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

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