DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and DIP-gamma

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	85/307 - (27%)
Similarity:	122/307 - (39%)	Gaps:	71/307 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 LNFTRLHRDDAGIYSCSASNS----QGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVE 795
            |..::|...|.|.|.|..:.|    |.|.   |.|.|......:..|.::.|..||||.|:|...
  Fly   106 LKISKLRESDRGCYMCQINTSPMKKQVGC---IDVQVPPDIINEESSADLAVQEGEDATLTCKAT 167

  Fly   796 GKPLTEEHVKWERVGYDM----------TVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVD 850
            |.|  :..|.|.|...:|          .:|..:  .||:| |.:...:|..:|.:.|:|.|.|.
  Fly   168 GNP--QPRVTWRREDGEMILIRKPGSRELMKVES--YNGSS-LRLLRLERRQMGAYLCIASNDVP 227

  Fly   851 NPTNRDILLIVKFAPEIAKTPTLLRAASGT--GERGRLPCRAQGSPKPQFIWRQDKK-------- 905
            ...::.:.|.|:|||.:.....||    ||  |...:|.|:.:.||.|...|.:..:
  Fly   228 PAVSKRVSLSVQFAPMVRAPSQLL----GTPLGSDVQLECQVEASPSPVSYWLKGARTSNGFASV 288

  Fly   906 ----------------DLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGE 954
                            |.|     ||.:.||: |.......|:|...:|:|.|.|.||:.|.||.
  Fly   289 STASLESGSPGPEMLLDGP-----KYGITERR-DGYRGVMLLVVRSFSPSDVGTYHCVSTNSLGR 347

  Fly   955 AVETVRL-EITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYR 1000
            |..|:|| ||...|....|    |..|        ..:.|||:.:.|
  Fly   348 AEGTLRLYEIKLHPGASAS----NDDH--------LNYIGGLEEAAR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	11/35 (31%)
		IGc2	692..757	CDD:197706	7/25 (28%)
		Ig	788..849	CDD:143165	19/70 (27%)
		Ig	885..960	CDD:143165	26/98 (27%)
		FN3	967..1051	CDD:238020	8/34 (24%)
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	11/35 (31%)
		Ig	47..129	CDD:299845	7/22 (32%)
		Ig	140..238	CDD:299845	26/102 (25%)
		IG_like	247..355	CDD:214653	32/117 (27%)
		Ig	256..351	CDD:299845	26/100 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910