DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and side-IV

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	1175	Identity:	232/1175 - (19%)
Similarity:	384/1175 - (32%)	Gaps:	328/1175 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 ELMCRSRGGNP---PAQLIWYK--------NG-SQIRMAYRTSGRLSENI---YTFTAEAG--DN 351
            |..||.:...|   |:..:|.:        :| ||:...|.....|.:|:   ...|...|  ..
  Fly    23 EPCCRKKPTAPHPFPSPNVWRQLLLPLLMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGR 87

  Fly   352 KARFRCEASNVMSQNPLKAE--VELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKW 414
            :|...|:.|      |.:.:  |.:.:.|             |.||..|:            ..:
  Fly    88 QAMLPCDIS------PQERDDAVYMVLWF-------------REGDGEPI------------YNF 121

  Fly   415 MVGGRQVRNA---TSKTIVSPEGGWTTTS--------NITAVVEPNKRSLVVICHGLNMQLTENV 468
            .|.|||...|   :|.|.......:::|:        ||....|...|..|...:.....|..|
  Fly   122 DVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVYRCRVDFRNSPTRNLKIN- 185

  Fly   469 VSTHTINVLYPPAPPLISGYMEGQIIPAGSVQK--------LLCVSSGGNPLATLTWYKNDKRIN 525
                 :.|:.||..|:|  |.:.:...||:|:.        |.|..|||.|...:|||.::..|:
  Fly   186 -----LTVIVPPDRPVI--YGQNRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYLDNTAID 243

  Fly   526 SVIRAADKSVSAEITILANVSDNQAQYR--CEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE 588
            ..........:.......||.......|  |.|||:....|..:...|.|:..|..|.|..:...
  Fly   244 ESFEQRPDGKTINHLSYPNVGRQHLNSRLMCVASNTNLTPPNNRVVILDVNLKPIAVHILTKDRF 308

  Fly   589 LRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGI-NNTSKPGLWGGTVSTLEFRVNVTQEMNGQV 652
            :.......:.|.||.|.|||.::|||....::.: .|.::|.  ..::|.|.|...  :|.:|:.
  Fly   309 VSADRTYDVECKSSGSKPPALITWWKGSKQLKKLTKNFNEPD--NQSLSILTFTPG--REDDGKY 369

  Fly   653 YTCQSANEALQRSA-HEAVSLDVLYRPKFVPPPSSTAVG--------VEGESLQVSLQTRANPTP 708
            .||::.|:.:..|| .:...|.|.|:     |.::..:|        .||:.........|||.|
  Fly   370 LTCRAENQFIDGSAIEDKWRLIVHYQ-----PTTTLKIGSSLNPDDIKEGDDAYFECIVLANPKP 429

  Fly   709 VTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQG-GATLNITVVVEYGTT 772
            ....|..:|..:..:....:.....||....:.|..||.|:|.|.||:| |.:..:|:.:.|...
  Fly   430 YKMSWFHNGKELQHNISAGVILSDQSLVLQSVSRASAGDYTCLAVNSEGKGPSNPVTLRIRYAPI 494

  Fly   773 IKSVSENIV-VNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKRE 836
            ..:..|.:: ....|...|.|.|:..| ..:..:|             ||
  Fly   495 CATDHEELLGALKHETLPLKCEVDSSP-PADSFQW-------------TF--------------- 530

  Fly   837 DVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWR 901
                                                     :.:||:..||.|...|
  Fly   531 -----------------------------------------NSSGEQTELPARLHSS-------- 546

  Fly   902 QDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITS- 965
                             |..:..|.|..:      ...|||...|.|:|.:|........:|.:
  Fly   547 -----------------ETGMSRLNYTPS------TDLDYGTISCWAKNSIGTQKSPCVFQIVAA 588

  Fly   966 -QPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSH---KLTIG 1026
             :|.|..:.::.|.:.|::.:....||||||...:.:  .:.:....:....:..||   ...|.
  Fly   589 GRPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFML--ELVELNTLRLARNITVSHTPVTFVID 651

  Fly  1027 GLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLL 1091
            .|.....|...:.:.|..|:|.             |......:..|....|.:.|.|    .|.|
  Fly   652 NLDQAATYRMVIFAVNAKGRSE-------------PTIIDDINFKGVAKFTGASTGL----SMPL 699

  Fly  1092 VGVGAGIVVVLLNVFVIGCCL---------HKRNEKRLKRGLE-------------LMPAELTED 1134
            ....||:.:....:|.|.|.:         ::|::..||....             |.|...|:.
  Fly   700 SPFLAGLTLFCGLLFAIFCIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLDPLHPGVQTDG 764

  Fly  1135 SSN-TPNLVII---------------------GISLAAFGFLLVNA--SLVAWFFVHQRRKKVAE 1175
            |.| .|:..::                     |:.:...|.:..::  .|||         ...:
  Fly   765 SGNHQPHHSLLPLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSPIGLVA---------MPGD 820

  Fly  1176 TTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVE-- 1238
            |....|:.....|...:..:|| ..:.:.:..||....|.  .|.|.:.....:.....||.|
  Fly   821 TLRSNARNRHSPMADQADIDDT-DPDVIPNQYEKRPLKSL--VSPPGFASPSNRLMQRDYLRETE 882

  Fly  1239 ----GSDMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLIS------KGV 1293
                |||:.....:...::.::               .::|:..:|.|......||      ||:
  Fly   883 LTKGGSDVGMGAAEGLSSIGLM---------------SSSGNEVLHYTFRPSKQISYATLNKKGI 932

  Fly  1294 YIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQP--MTVTSLAT----NG 1352
                 :...||.||   :|.....|.|...|    ..|.|||.::.|.|  .:|||..:    ..
  Fly   933 -----TTCSPPLGS---LNYSVSTSTPTSSY----HLTPQPMEVSLLSPNNPSVTSSLSEYRFRT 985

  Fly  1353 GPTLI 1357
            ||.::
  Fly   986 GPEIV 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	19/90 (21%)
		Ig	300..361	CDD:299845	16/73 (22%)
		Ig	380..454	CDD:299845	16/84 (19%)
		IG_like	490..573	CDD:214653	22/92 (24%)
		Ig	501..560	CDD:299845	17/68 (25%)
		Ig	584..666	CDD:299845	20/82 (24%)
		IG_like	585..666	CDD:214653	20/81 (25%)
		I-set	678..767	CDD:254352	23/97 (24%)
		IGc2	692..757	CDD:197706	18/64 (28%)
		Ig	788..849	CDD:143165	7/60 (12%)
		Ig	885..960	CDD:143165	14/74 (19%)
		FN3	967..1051	CDD:238020	18/86 (21%)
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	27/145 (19%)
		IG_like	80..188	CDD:214653	26/144 (18%)
		Ig	210..281	CDD:299845	17/70 (24%)
		Ig	319..392	CDD:299845	23/76 (30%)
		IG_like	319..383	CDD:214653	20/67 (30%)
		IG_like	412..489	CDD:214653	21/76 (28%)
		IGc2	413..478	CDD:197706	18/64 (28%)
		Ig_3	509..572	CDD:290638	22/163 (13%)
		fn3	593..675	CDD:278470	17/96 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810