DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and dpr13

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	99/477 - (20%)
Similarity:	146/477 - (30%)	Gaps:	199/477 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 SPEGGWTTTSNITA-VVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQII 494
            ||.||.|..:.:|. ..||:.|           .:.:|::               :|...||:.:
  Fly    45 SPGGGKTVAATMTTPASEPSVR-----------HINQNLI---------------MSQSKEGEPV 83

  Fly   495 PAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQ-------- 551
            |..........|:||                |.|.:.|.:         ||.|.|:|
  Fly    84 PVPQPYAQSAASAGG----------------SSITSFDST---------NVIDGQSQPTPTHLQE 123

  Fly   552 --------YRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE-LRPGMEATIICDSSSSNPP 607
                    .|.:|.::|...|      :.|| .||.|:..:|... :..|||:..
  Fly   124 AVLQTHSHSRIQAKDTAGPYP------IPVH-RPEPVENHLEANNGIEGGMESLF---------- 171

  Fly   608 AKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSL 672
                    |.|           ::.||             .|..|.|.|     :..:||
  Fly   172 --------GTP-----------MYFGT-------------ENSTVVTTQ-----IGATAH----- 194

  Fly   673 DVLYRPKFVPPPSSTAVGVEG----------ESLQVSLQTRANP---TPVTYKWTKDGTTIPQDG 724
                     .|.:...:| ||          ..|.|.|.|.::.   :....|.::|.|.
  Fly   195 ---------VPCTVHHIG-EGVVSWIRKKDYHLLTVGLTTYSSDERFSATHLKHSEDWTL----- 244

  Fly   725 DHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVE-----YGTTIKSVSENIVVNP 784
                     .:.|.:|.  |||:|.|..|.....:......|||     .|..|:      .:.|
  Fly   245 ---------QIKFVQLR--DAGVYECQVSTHPPTSIFLHLSVVEARAEITGPPIR------YLTP 292

  Fly   785 GEDAMLSCTVEGKPLTEEHVKW----ERVGYD----MTVKTSTTFANGTSYLHIKDAKREDVGNF 841
            |....|.|.|.......|::.|    ..:.||    :.|.|...|.  :|.|.|:..:||..|||
  Fly   293 GSTLRLQCRVVQNTEASEYIFWYHDNRMINYDIDRGINVSTEPDFQ--SSELTIQRTRREHSGNF 355

  Fly   842 RCVADN-----------RVDNP 852
            .|||.|           :.|||
  Fly   356 TCVASNTQPASVLVHIFKGDNP 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	9/23 (39%)
		IG_like	490..573	CDD:214653	18/98 (18%)
		Ig	501..560	CDD:299845	13/74 (18%)
		Ig	584..666	CDD:299845	12/82 (15%)
		IG_like	585..666	CDD:214653	12/81 (15%)
		I-set	678..767	CDD:254352	19/101 (19%)
		IGc2	692..757	CDD:197706	17/77 (22%)
		Ig	788..849	CDD:143165	22/79 (28%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	25/131 (19%)
		IG_like	182..262	CDD:214653	23/115 (20%)
		IG_like	285..362	CDD:214653	24/84 (29%)
		IGc2	292..361	CDD:197706	23/70 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910