DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and side-V

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	1356	Identity:	274/1356 - (20%)
Similarity:	448/1356 - (33%)	Gaps:	446/1356 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 IVWYR-GNVEYKPEKREDT-----------VEESTAKR------FTTTSSLKLKPGPDDDYTEYT 257
            ::||| |||  ||....|.           .:||...:      .|...:|::|.....|...|.
  Fly    71 VIWYRQGNV--KPIYTFDARGRPLNLGIPWADESVFNKKAHFHHDTDPPALRIKNIQTSDAGLYK 133

  Fly   258 CQAR-HKALSPDMPMRATVQLSVLYPP-----------------GPPYIEGYSAGETLRRGQTVE 304
            |:.. ||  ||....|  :.::||.||                 ..||:|          |.:::
  Fly   134 CRVDFHK--SPTRNWR--INVTVLVPPTALTILDHHGAEIRDQTAGPYLE----------GDSID 184

  Fly   305 LMCRSRGGNPPAQLIWYKNGSQIRMAYRT--SGRLSENIYTFTAEAGDNKARFRCEASNVMSQNP 367
            |.|.|.||.||.::.|::..:.|..:::.  .|.:...:.....:..|....:.|:|||......
  Fly   185 LTCLSSGGVPPPRVSWWREHALIDDSFQVLPDGSVRNVLRLKNIQRKDLLTMYTCQASNGHVVPA 249

  Fly   368 LKAEVELSVLFAPTHVTVMGPTEARV-GDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVS 431
            |..:|.|.:...|..:.:.|...|.: |....:|||...:.||.||.|...|:.||.|||.|  |
  Fly   250 LTKKVILDMNLPPLSLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIWSKAGQIVRGATSST--S 312

  Fly   432 PEGGWTTTSNITAVVEPNKRSLVVICH-GLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIP 495
            .:|. ||.|.:..:..|......|:|. .||..:|                         .|.:.
  Fly   313 SDGN-TTISELMLIPVPEDNERQVVCSISLNAGIT-------------------------SQQLH 351

  Fly   496 AGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSA 560
            .|....:..:.:|...|     |..|.|:.:|..|.          :.|::..
  Fly   352 EGHTTVMTTLGNGHTGL-----YLKDSRVLNVTHAP----------IVNLNLG------------ 389

  Fly   561 TEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEG---- 621
                           ||      ::|:.|..|.:..:.||..::....::.|:.....:..
  Fly   390 ---------------AP------LDPDNLLKGTDVYLECDVKANPAITRVEWYHSDKQLHSSRGI 433

  Fly   622 -INNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPS 685
             |:|           .||..: .:::..:|| |.|:::|.....|::| |.|||.|.|  |....
  Fly   434 IISN-----------QTLVLQ-GISKSSHGQ-YFCRASNLQGSVSSNE-VYLDVKYPP--VCKSE 482

  Fly   686 STAV-GVEGESLQVSLQTRANPTP-VTYKWTKDGT-----TIPQDGDHR-IFADGGSLNFTRLHR 742
            ||.: ....:::.::.:..|||.. :.|||..:.:     .:||.|... :....||
  Fly   483 STIIRAALKQTINITCEVDANPVDNLNYKWHFNNSLESLIELPQLGQGAPVMLASGS-------- 539

  Fly   743 DDAGIYSCSASNSQGGATLNITVVVEYG-----TTIKSVSENIVVNPGEDAMLSCTVEGKPLTEE 802
            |.:|.|..|......|....:.    :|     ..::...|:      ||        |....||
  Fly   540 DQSGYYQRSKRKHSHGMQQRLL----HGRHGRMAAVRFEDED------ED--------GYGEFEE 586

  Fly   803 HVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEI 867
            :  .:.||...   |...::|.....|::.:|::.                      ..:.:|:.
  Fly   587 Y--GDEVGQPF---TQMVYSNMVHKNHVESSKQQQ----------------------RKQLSPQQ 624

  Fly   868 AKTPTLLRAASGTG-----------ERGRL--------------PCRAQGSPKPQFIWRQDKKDL 907
            .:....:.:...:|           ||.||              |.....:|
  Fly   625 QQQQQQMASGGSSGDSHTPSGGVILERKRLVALHKQHHRGGVATPPTTTAAP------------- 676

  Fly   908 PINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVET-VRLEITSQPDPPL 971
            |:|..|.|.||       :|||           :||..|||.:.:|.:... ..::....|:|..
  Fly   677 PLNNVYSYHVE-------SYES-----------FGAISCVASSPMGHSAPCWYHIQPADLPEPVK 723

  Fly   972 SLNILNVTHDTVTLAWTPGFDGGLKASYRVR-YRMADRE-----QYKYIDGLPNSHKLTIGGLRM 1030
            :....|.|.:::.:...||:|||:...:..: |...:|:     .|||       .:.|:..|..
  Fly   724 NCTAYNATANSLQIQCIPGYDGGIPQHFHAQIYDELNRQILYNASYKY-------SEFTVKRLPS 781

  Fly  1031 NTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVG 1095
            :::::..:.:.|..|.|.....| |..|..| |....|||..   .....|||.|.    ||||.
  Fly   782 DSVFVIRITAVNAQGASKVAYRL-RGRTLSA-PLLRTASSTA---VLVQLTPLLGA----LVGVI 837

  Fly  1096 AGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASL 1160
            |.:::|.:.|.::       .:.|.|||
  Fly   838 ATLILVAICVVIV-------IKFRSKRG------------------------------------- 858

  Fly  1161 VAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYID 1225
                  .:|....|:.|...|...:.|   |.|.|   .|...|...:..:....|.:|:.|:..
  Fly   859 ------GRRHGSGADATTTEADKGSAE---PLSRN---MGSHSSLEDKNPDVVPQEANSEDEFHQ 911

  Fly  1226 EVRKKAASTYLVEGSDM---PPPRYQKDGTLPVIYPNNVVNACTLPHPR--------------HN 1273
            |  :||.....:|...:   ||.|               :|..:.|.|.              ..
  Fly   912 E--EKAFDRLNMESQRILYTPPTR---------------INTASPPPPSLSPTFGKQYGELSLTT 959

  Fly  1274 NGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEY-------------- 1324
            |.:.:::.|......:.:.||     .||||      :.|.|   .||..|
  Fly   960 NPAFSLYNTPQRAPAVQRPVY-----TAPPP------LLSTR---TPPNIYTRIPGRGGGGGGAT 1010

  Fly  1325 -----------PAALDFTAQPMPMAHLQPMTVTSLA--TNGGPTLIGNGSVAAVAGGS------- 1369
                       ||....|:...|.......|:..|.  :||.....|.|.|..:.||.
  Fly  1011 VTAAGAGGYHLPAYETRTSPTSPYGSTTTCTMPLLGGQSNGSLQSGGVGGVGGLVGGGACNTLPH 1075

  Fly  1370 -GTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNG 1424
             |:|..|   |:.......||....|:|.:...:      .:..:.|.|.||||.|
  Fly  1076 PGSLHVG---GISAALTSSVTSGNITIGAAQSLL------TSPRSQTATYSTTLGG 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	22/86 (26%)
		Ig	197..279	CDD:299845	22/86 (26%)
		IG_like	296..376	CDD:214653	19/81 (23%)
		Ig	300..361	CDD:299845	14/62 (23%)
		Ig	380..454	CDD:299845	25/74 (34%)
		IG_like	490..573	CDD:214653	10/82 (12%)
		Ig	501..560	CDD:299845	8/58 (14%)
		Ig	584..666	CDD:299845	15/86 (17%)
		IG_like	585..666	CDD:214653	15/85 (18%)
		I-set	678..767	CDD:254352	20/96 (21%)
		IGc2	692..757	CDD:197706	15/71 (21%)
		Ig	788..849	CDD:143165	9/60 (15%)
		Ig	885..960	CDD:143165	19/89 (21%)
		FN3	967..1051	CDD:238020	19/89 (21%)
side-V	NP_611765.2	Ig	42..153	CDD:299845	22/87 (25%)
		IG_like	42..152	CDD:214653	22/86 (26%)
		IGc2	179..245	CDD:197706	17/75 (23%)
		IG_like	179..245	CDD:214653	17/75 (23%)
		Ig	<282..348	CDD:299845	26/93 (28%)
		IGc2	400..459	CDD:197706	12/71 (17%)
		FN3	719..798	CDD:214495	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810