DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Il18rap

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_017452283.1	Gene:	Il18rap / 373540	RGDID:	727867	Length:	627	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	74/362 - (20%)
Similarity:	130/362 - (35%)	Gaps:	94/362 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 QSTTLSVHFAPETVKIRIEPEELRPGMEATIICD--------------SSSSNPPA--------- 608
            :.||...|.|..|.|: :.....|......:.||              |||:..||
  Rat    15 EKTTGFNHSACTTKKL-LWTYSARGAENFVLFCDLQELQKQDFSHRSQSSSTLGPAHQPCSGSEK 78

  Fly   609 ---KLSWW---KDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAH 667
               .:.|:   :.|.|:|.||..|......||:..|..::|....     |.|:..:   :|...
  Rat    79 DLSDVQWYMQPRSGGPLEEINRNSPHMQNKGTLRILAPQMNSIWS-----YICRPRS---RRPQD 135

  Fly   668 EAVSLDVLYRPKFVPPPSSTAVGVEGESLQV------------SLQTRANPTPVTYKWTKDGTTI 720
            .|..:..:..   |.|..:.:.|...:..||            ||..:::.......|.|||..:
  Rat   136 TACCVKTVLE---VKPQRNISCGSSAQDEQVLLLGSTGSIHCPSLSCQSDVRSPEMTWYKDGRLL 197

  Fly   721 PQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNP- 784
            |:...:.|..:    :....|:   |:|.|..:.|...::..:..||:    ::::.|:..|.|
  Rat   198 PEYKKNPIEME----DIYDFHQ---GLYVCDYTQSDNVSSWTVRAVVQ----VRTIDEDTNVKPD 251

  Fly   785 -------------GEDAMLSCTVE------GKPLTEEHVK-----WERVGYDMTVKTSTTFANGT 825
                         |:...|.|.|:      .||:.:.:||     || :...:..:..:|..|..
  Rat   252 ILDPVTDTLDVELGKAFTLPCRVQFGFQRYSKPVIKWYVKESTQEWE-ISEFVEKRIQSTLKNEV 315

  Fly   826 --SYLHIKDAKREDVG-NFRCVADNRVDNPTNRDILL 859
              ..:.:::..:.|:. .|.|.|.|.:.| |.|.|.|
  Rat   316 IEHTVFLREVTQRDLSRKFVCFAQNSIGN-TTRTIRL 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	2/5 (40%)
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	22/110 (20%)
		IG_like	585..666	CDD:214653	22/109 (20%)
		I-set	678..767	CDD:254352	18/100 (18%)
		IGc2	692..757	CDD:197706	15/76 (20%)
		Ig	788..849	CDD:143165	16/74 (22%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Il18rap	XP_017452283.1	Ig_6	101..154	CDD:408247	11/63 (17%)
		Ig	263..353	CDD:416386	22/91 (24%)
		Ig strand B	266..275	CDD:409353	2/8 (25%)
		Ig strand C	284..289	CDD:409353	1/4 (25%)
		Ig strand D	297..308	CDD:409353	2/11 (18%)
		Ig strand E	314..322	CDD:409353	0/7 (0%)
		Ig strand F	333..339	CDD:409353	2/5 (40%)
		Ig strand G	343..349	CDD:409353	3/6 (50%)
		TIR	410..558	CDD:396246
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910