DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and Strn-Mlck

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster


Alignment Length:1606 Identity:323/1606 - (20%)
Similarity:529/1606 - (32%) Gaps:509/1606 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 FRTTPHDLQVLEGAEAMMRCEVANVAGA-VQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIY--- 134
            |.|..||..|.|||...:.|.|:..... ::|.|:...|         ||..   :|.|.:|   
  Fly  5786 FHTLLHDRTVSEGANLRLVCSVSGDENTHIEWLKNHKPL---------PRSD---NRYQTVYLNG 5838

  Fly   135 --NLRISNASINDDADYQC----QVGPARLNSAIRA--NAKLTVISPPASIEIKG-YSHNSKVEV 190
              :|.|..|..:|..:|.|    ..|.:..::.:|.  |.|...:....:..|:. ||.|     
  Fly  5839 EASLEIFAAVADDSGNYTCCATNDFGESLTHAQLRV
YKNFKEAPLPSTFTQPIRDTYSLN----- 5898

  Fly   191 RENQDLQLKCIVANAKPAAQIVWYRG------NVEYKPEKREDTVEESTAKRFTTTSSLKLKPGP 249
             || :|.|.|.| ..:|..:|.|.:|      :.::||..:.|..           :.|.:....
  Fly  5899 -EN-ELVLDCRV-RGQPRPEIQWIKGTEPIEASEKFKPSDQADGY-----------AKLVIVNPT 5949

  Fly   250 DDDYTEYTCQARHKAL------SPDMPMRATVQLSVLY-----PPGPPYIEGYSAGETLRRGQTV 303
            :.|...|.|.||::..      ..|...|....|...:     .|..|:.......:|:..|.||
  Fly  5950 EKDSGIYWCVARNEGAENKIS
HQVDFKGRQHYSLEKTHGFFHRDPNKPHFLLPLGNQTVCNGGTV 6014

  Fly   304 ELMCRSRGGNPPAQLIWYK-----NGSQIR-MAYRTSGRLSENIYTFT-AEAG-DNKARFRCEAS 360
            .:.......:.|.::.|.:     :|..:: :|.|       .:||.| ..|| :.:..:.|.||
  Fly  6015 AISAEFMETSTPIEVKWLRDRRVVDGPNVKALADR-------GVYTLTIMNAGPEVEGTYTCRAS 6072

  Fly   361 NVMSQNPLKAEVELSV---------LFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMV 416
            |...:......|:::|         ||.....|.|   :..|||...|:...| .:|..::.:|.
  Fly  6073 NAFGRIESNVNVDV
AVGAEKDERPPLFLSRPDTEM---KIAVGDPFSLSFRIA-GDPKPKLTFMK 6133

  Fly   417 GGRQVRNATSKTIVSPE--GGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYP 479
            |.:.:   |....||.|  ..:|..|...|.:..:....||..:...   |:.:..|.|:|....
  Fly  6134 GTKDI---TQSDRVSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFG---TDRIFVTVTVNPRAR 6192

  Fly   480 PAPPL-------ISGYMEGQII--PAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSV 535
            .|.|.       :..|.:....  |.|.:.....|...|....:|:|.|.....::.:.|    .
  Fly  6193 SATPTQPRWGLPLDSYSDTSYFRDPPGCISTEPLVVDSGPTHISLSWGKPVSANSAPVMA----Y 6253

  Fly   536 SAEITILA---------------------NVSDN-QAQYRCEASNSATEIPLFQSTTL----SVH 574
            ..|..::.                     |:..| :..:|....|.....|..|:::.    .|.
  Fly  6254 KVEAWVVGHEGGAYWRELGLTPINSFDAFNLKPNVEYHFRVTPKNRYGWGPTVQTSSPLQVGGVE 6318

  Fly   575 FAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLE 639
            ..||.|||.....:...|...|:.|:...: |..:::|:||||.:...:...|....|   ||..
  Fly  6319 CLPEFVKILPGQAKALLGSSFTLQCNMRGA-PRPQVTWFKDGIQLSSSSERVKIRQIG---STCA 6379

  Fly   640 FRVNVTQEMNGQVYTCQSANEALQRSAH---EAVSLDVLY----RPKFVPPPSSTAVGVEGESLQ 697
            ..:....|::...|||::.|...:.|..   :.||...:|    |.|.:  .....|...|:||.
  Fly  6380 LTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSRIYEADSRLKEI--AHGRNVADVGDSLP 6442

  Fly   698 V-SLQTRANPTPVTYK----------------WTKDGTTIPQDGDHRIFADGG--SLNFTRLHRD 743
            : :::.|.....|||.                |.||...|..|..|.|.|:|.  :|.......|
  Fly  6443 IFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDDELIHTDRKHLISAEGQFFTLEIAATTLD 6507

  Fly   744 DAGIYSCSASNSQGGATLNITVVVEYGTTIKS-VSENIVV--------NPGEDAMLSCTVEGKPL 799
            |:|.|:|.|.|..|..:.:.|:||:.|  |:: :|.:..|        ..|.:..||..||..| 
  Fly  6508 DSGTYTCLARNELGSVSCHCTLVVDKG--IRAYISPDFYVPLDPFYIFREGSEIRLSTKVEAYP- 6569

  Fly   800 TEEHVKWERVGYDMTVK---TSTTFANGTSYLHIKDAKREDVGNFRCVADNRV------------ 849
             ...|.|.|.|..:...   |:|..:||...|.|.:|...|.|.:.|||.|.|            
  Fly  6570 -SVGVTWHRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVASNVVGKVETICRVAVE 6633

  Fly   850 ---------------------DNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGS 893
                                 |.|.:::.|.:||  |..::        :..|:...:.|...|.
  Fly  6634 EAENKAVAPQRSLEIPSIKTDDLPYSKEPLFVVK--PRSSE--------AYEGDNVIIFCEVVGD 6688

  Fly   894 PKPQFIWRQD------KKDLPINR------TYKYEVEERKIDSLTYESTLIVDKVAPADYGAYEC 946
            |||:.:|.:|      .||.|..|      .|:.|:...|:|..                |.|..
  Fly  6689 PKPEVVWLRDFLNPEYYKDAPHFRRIGDGPEYRLEIPSAKLDFT----------------GTYSV 6737

  Fly   947 VARNELGEAVETVRLEI-------TSQPD------------PPLSLNILNV---THDTVTL---- 985
            :|.|..|||...:.|:|       .|:.|            |....|:.|:   ..|.::|    
  Fly  6738 IASNCHGEAKAVISLQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHV 6802

  Fly   986 --------AWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLY-----LFS 1037
                    .|..  ||.:..|        ||:.....||       |...|.:..:|     .::
  Fly  6803 EADPEPFIIWEK--DGHVMPS--------DRDYVMSFDG-------TKATLSIPRVYPEDEGEYT 6850

  Fly  1038 VMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVL 1102
            .::.|.:|:|.                                     :|..::|.|..      
  Fly  6851 CVAKNSVGRSL-------------------------------------SSACIIVDVPE------ 6872

  Fly  1103 LNVFVIGCCLHKRN--EKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFF 1165
                      .|.|  .::|.|...|:.|..|..|  ||.                         
  Fly  6873 ----------EKENMLSRQLARPSGLLSAHSTPRS--TPR------------------------- 6900

  Fly  1166 VHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYI------ 1224
                        :.||::     ::|...:...:...||.|:|:..|.:....:.|:::      
  Fly  6901 ------------STPARS-----FSPLRLSYRTSSIDLSGVAERRRSDARNAITAPKFLAIPYNR 6948

  Fly  1225 -----DEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRD 1284
                 |.||.:.|    :.|...|...:.|||.:            ..|.||     .|:....|
  Fly  6949 VVEEGDSVRFQCA----ISGHPTPWATWDKDGLI------------VTPTPR-----IAVKEIDD 6992

  Fly  1285 DQML-ISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALD------FTAQPMPMAHLQP 1342
            .::: |.:..:         .|...|.:..:.  .:..:|..|.||      ::..|    .::.
  Fly  6993 LRIIEIDEVTF---------DDAGLYRVTLEN--DFGRIEATARLDVIRSSRYSKSP----SVRS 7042

  Fly  1343 MTVTSLATNG-------GPTLIGNGSVAAVAGGSGTLRRGI------------------------ 1376
            :..:|...|.       ||:....|.:|..:|..|:....:                        
  Fly  7043 VRASSSRRNAHLYRRIMGPSTAIGGRMALASGYRGSSVPSVRFYHNDVELEASERVHILLQDSMA 7107

  Fly  1377 LRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTL 1422
            |..|..|.:.|...:|..:.|.     ||         .|.||||:
  Fly  7108 LLIVDNVTREDEGQYTCIISGD-----HD---------PLITSTTV 7139

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352 28/107 (26%)
Ig 76..155 CDD:299845 23/88 (26%)
IG_like 186..279 CDD:214653 22/104 (21%)
Ig 197..279 CDD:299845 19/93 (20%)
IG_like 296..376 CDD:214653 19/87 (22%)
Ig 300..361 CDD:299845 15/68 (22%)
Ig 380..454 CDD:299845 17/75 (23%)
IG_like 490..573 CDD:214653 15/110 (14%)
Ig 501..560 CDD:299845 11/80 (14%)
Ig 584..666 CDD:299845 18/81 (22%)
IG_like 585..666 CDD:214653 18/80 (23%)
I-set 678..767 CDD:254352 28/107 (26%)
IGc2 692..757 CDD:197706 24/83 (29%)
Ig 788..849 CDD:143165 22/63 (35%)
Ig 885..960 CDD:143165 22/86 (26%)
FN3 967..1051 CDD:238020 20/115 (17%)
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352 25/99 (25%)
IGc2 5797..5864 CDD:197706 19/78 (24%)
I-set 5887..5970 CDD:254352 23/101 (23%)
Ig 5902..5966 CDD:143165 17/75 (23%)
I-set 5997..6086 CDD:254352 20/95 (21%)
Ig 6026..6083 CDD:143165 14/63 (22%)
I-set 6097..6187 CDD:254352 23/99 (23%)
Ig 6114..6187 CDD:299845 16/79 (20%)
FN3 6216..6310 CDD:238020 15/97 (15%)
I-set 6321..6412 CDD:254352 24/94 (26%)
Ig 6328..6412 CDD:299845 19/87 (22%)
I-set 6442..6531 CDD:254352 23/88 (26%)
Ig 6459..6528 CDD:143165 18/68 (26%)
I-set 6541..6632 CDD:254352 25/92 (27%)
IGc2 6555..6622 CDD:197706 23/68 (34%)
I-set 6662..6754 CDD:254352 28/117 (24%)
Ig 6679..6751 CDD:143165 22/87 (25%)
I-set 6779..6868 CDD:254352 20/142 (14%)
IGc2 6793..6858 CDD:197706 14/81 (17%)
Ig 6938..7022 CDD:299845 18/115 (16%)
I-set 6939..7028 CDD:254352 21/120 (18%)
IG 7075..7140 CDD:214652 14/79 (18%)
Ig 7075..7140 CDD:143165 14/79 (18%)
IG 7167..7239 CDD:214652
Ig 7173..7239 CDD:143165
Ig 7392..7475 CDD:299845
IG 7406..7475 CDD:214652
FN3 7489..7588 CDD:238020
S_TKc 7620..7876 CDD:214567
STKc_MLCK 7626..7876 CDD:271005
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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