DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and CG17716

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001286391.1	Gene:	CG17716 / 36521	FlyBaseID:	FBgn0000633	Length:	822	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	167/843 - (19%)
Similarity:	268/843 - (31%)	Gaps:	307/843 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 ISNASINDDADYQCQVGPAR-LNSAIRANAK----LTVISP----PASIEIKGYSHNSKVEVREN 193
            ||....::..|::....||: ..:..:|.||    .|.:.|    ..:::.|......:.|..|:
  Fly    59 ISAEPADEVVDHRGGGKPAKCAKNCQKAKAKWAKWRTQLKPHHQAHRAVQHKEARQRQRRETEED 123

  Fly   194 Q-DLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSL---KLKPGPD---- 250
            : |..|:...:.:...|.....:.........|...:.|:.|||..:|..|   .::|.|.
  Fly   124 ELDAVLRAPSSTSTSTAVATTVQATSSSSSATRSSVINETKAKRPRSTLHLAPEDMQPKPKEPVI 188

  Fly   251 --DDYTEYTC----------QARHKA--------LSPD-MPMRATVQLSVLYPPGPPYIEGYSAG 294
              ||..|:..          ::|.:|        |.|. :|:|..       ||.|     |.|.
  Fly   189 IIDDVEEFDSGTSTSDLIARKSREEAEEEEDEGPLEPRVLPLRPV-------PPNP-----YEAE 241

  Fly   295 ET----LRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAG------ 349
            |.    ..:...::|||..  ....|..:|||||..:....||: |:::  |.|..||.
  Fly   242 EMSVVYAEQHSEIKLMCEV--DLDIATSMWYKNGQVVHAMDRTA-RVTD--YRFIKEANGALTIT 301

  Fly   350 ----DNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPA 410
                ::..:::|||.|..........|:|.||..|                          .||
  Fly   302 NVMLEDDGKWQCEAENTRRYTENARPVKLVVLDRP--------------------------KPP- 339

  Fly   411 EIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTIN 475
              ..::..|::                ..||:...|:.|..        ||
  Fly   340 --YLLIDSRRL----------------DASNLFVPVKENSE--------LN-------------- 364

  Fly   476 VLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEIT 540
                                      |.|||.||||..||||   :..::..:....:.||||:
  Fly   365 --------------------------LACVSEGGNPRPTLTW---EVLLSPGVDRHAQKVSAEV- 399

  Fly   541 ILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSN 605
                                                       :|.||::
  Fly   400 -------------------------------------------LELEEIK--------------- 406

  Fly   606 PPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAV 670
             ..||.  |||..|.           .|..|............|.:: .|...:..|:...:.::
  Fly   407 -GEKLD--KDGYKIN-----------SGAKSEARLPAVYRAHHNARI-LCVMEHPTLKIRQNASL 456

  Fly   671 SLDVLYRPKFVPPPSSTAVGV-----EGESLQVSLQTRANPTPVTYKWTKD--GTTIPQDGDHRI 728
            .|||.|.|.|.   .|...|.     ||..:.:.....:|| |.|.:|.||  .|.:||.||
  Fly   457 LLDVQYTPSFA---ISRTPGFGYPLREGIEVSLKCDVDSNP-PSTPRWQKDDGDTPVPQTGD--- 514

  Fly   729 FADGGSLNFTRLHRDDAGIYSCSASN-----SQGGATLNI---TVVV-----EYGTTIKSVSENI 780
                |.||||.:.|:.:|.|.|::.:     |..|..|::   :|.|     :...::.:.|.|
  Fly   515 ----GFLNFTSIRREHSGWYKCTSRHLNFQYSSIGYYLSVRFDSVDVTSEPDDQDVSVAAASHN- 574

  Fly   781 VVNPGE--------------DAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIK 831
             .|.|:              ...|.|.....|::   .:...:||..        :..|....:|
  Fly   575 -PNKGQLEVQLGGAVTLQCPQGSLGCWSHLDPIS---ARLRGLGYGS--------SQPTGQFSLK 627

  Fly   832 DAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSP 894
            |...:|.|.::||.    .:|||:..|.:::......|....:.|.:.|      |....|||
  Fly   628 DVMYQDAGMYKCVG----QSPTNKKKLEVLQSVTVSVKGAPTVMALNAT------PVAYPGSP 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	8/36 (22%)
		Ig	76..155	CDD:299845	3/16 (19%)
		IG_like	186..279	CDD:214653	23/121 (19%)
		Ig	197..279	CDD:299845	20/109 (18%)
		IG_like	296..376	CDD:214653	22/93 (24%)
		Ig	300..361	CDD:299845	19/70 (27%)
		Ig	380..454	CDD:299845	8/73 (11%)
		IG_like	490..573	CDD:214653	16/82 (20%)
		Ig	501..560	CDD:299845	16/58 (28%)
		Ig	584..666	CDD:299845	14/81 (17%)
		IG_like	585..666	CDD:214653	14/80 (18%)
		I-set	678..767	CDD:254352	31/103 (30%)
		IGc2	692..757	CDD:197706	24/71 (34%)
		Ig	788..849	CDD:143165	12/60 (20%)
		Ig	885..960	CDD:143165	4/10 (40%)
		FN3	967..1051	CDD:238020
CG17716	NP_001286391.1	IG_like	244..332	CDD:214653	22/92 (24%)
		Ig	254..323	CDD:143165	20/73 (27%)
		Ig	359..452	CDD:299845	33/217 (15%)
		Ig_3	477..536	CDD:290638	23/66 (35%)
		IG_like	479..550	CDD:214653	26/78 (33%)
		IG_like	578..660	CDD:214653	17/96 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010