DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and side-II

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	1322	Identity:	252/1322 - (19%)
Similarity:	403/1322 - (30%)	Gaps:	490/1322 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 GQTVELMCRSRGGNPPAQ-------LIWYKNGSQIRMAYRTSGRLSEN----IYTFTAEAGDNKA 353
            |::|.|.|      |..:       ::|:::.:.|.: |....|..|:    .:....|...::|
  Fly    62 GKSVSLPC------PITEPLDNVYMVLWFRDNAGIPL-YSFDVRDKESREQPRHWSAPEVFGSRA 119

  Fly   354 RF-------------------RCEASNVMSQNPLKAEVELSVLFAPTHVTVM------------G 387
            :|                   ||......||.. .....|||:..|....:|            |
  Fly   120 KFHFDSQPATLEIKRHDQGIYRCRVDFRTSQTQ-SFRFNLSVIILPEQPIIMDRWGRQLNGTQLG 183

  Fly   388 PTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRS 452
            |.:.  ||.:.:||......|..:::|:|.|..|.|..                     |.|...
  Fly   184 PKQE--GDDIVITCRVVGGRPQPQVRWLVNGLLVDNQN---------------------EHNSGD 225

  Fly   453 LVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTW 517
            ::           ||       .:|:|                  |||
  Fly   226 VI-----------EN-------RLLWP------------------SVQ----------------- 237

  Fly   518 YKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKI 582
             :||  :|||                        :.|:|.|:..:.|..:|..|.:|..|..|||
  Fly   238 -RND--LNSV------------------------FTCQALNTQLDKPKEKSFILDMHLKPLVVKI 275

  Fly   583 RIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGI-NNTSKPGLWGGTVSTLEFRVNVTQ 646
            ...|..:.......:.|:||.|.|.|.::|:|....:... ::.||    ..|.|.|.| |..|.
  Fly   276 LEPPSSMIADRRYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISK----NSTRSELSF-VPTTD 335

  Fly   647 EMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTY 711
            : :|:..||::.|..:     ..:.|:.:::...|.||            .|:|:..:..||
  Fly   336 D-DGKSITCRAENPNV-----NGLYLETMWKLNVVYPP------------LVTLRLGSTLTP--- 379

  Fly   712 KWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSV 776
                                           ||
  Fly   380 -------------------------------DD-------------------------------- 381

  Fly   777 SENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNF 841
                 :..|:|....|.|:..|...: :.|...|..:...||.........|.::...:...||:
  Fly   382 -----IKEGDDVYFECHVQSNPQWRK-LLWLHNGIHLEHNTSARVIRSNQSLVLQKITKHYAGNY 440

  Fly   842 RCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQ-FIWRQDKK 905
            .|.|.|......:..:.|.||:.|.......::...:...|...:.|..|..|.|: |.|:.:
  Fly   441 ACSAINDEGETVSNQLPLRVKYTPMCKHADRVILIGASKDETVEVVCEIQADPPPRTFRWKFN-- 503

  Fly   906 DLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEI--TSQPD 968
                |.....:|...:.......|.|....|...|||...|.|.||:|........::  .:.|:
  Fly   504 ----NSGETLDVGSERFSVNGSRSILKYTPVTDQDYGTLSCWASNEVGTQQHPCLFQVVLAALPN 564

  Fly   969 PPLSLNILNVTHDTVTLAWTPGFDGGLKASYRV----------RYRMADREQYKYIDGLPNSHKL 1023
            ...:..:.|.|..:|.:...||:||||...:.:          |:.:::.|:..:  .|.|...|
  Fly   565 AVSNCTVFNRTELSVDIQCIPGYDGGLPQIFVLEMFSTRTGITRFNLSNAEEALF--SLENLDTL 627

  Fly  1024 TIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSG 1088
            |...::.|......:.|:|:.|:|:
  Fly   628 TSMMVQENNSLRLRIYSYNQKGRSA---------------------------------------- 652

  Fly  1089 MLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGF 1153
                       ..||..|:||...:|.::...   |.|.|..:    .:...::|||:::|...|
  Fly   653 -----------AYLLTDFIIGSTAYKTDDDVT---LTLSPVIV----GSVLTIIIIGVAIAIRIF 699

  Fly  1154 LLVNASLVAWFFVHQRRKK--------VAETTNQPA------------------KTATIEMYA-- 1190
            ::.        |||..|:.        .|..|.||:                  ||.:.|...
  Fly   700 VVT--------FVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPRWQHTDIKTKSSEDLVED 756

  Fly  1191 -------PSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQ 1248
                   ||.|   |.|   ||......:.||.||:           .|.|  ..||
  Fly   757 ERDPDVIPSQY---VGG---SSAGSSGSNASNVGST-----------TAGT--ATGS-------- 794

  Fly  1249 KDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNS 1313
            ...|..|...|...:|...|....::.||            :.|....|.:.|.....|.::.|.
  Fly   795 STSTAVVANANAAASAMAGPGGATSSASA------------TDGHQFASGTAAAGGGASKWSPNG 847

  Fly  1314 DRYLSYPPMEYPAALDFTAQPMPMAHLQPMTVTSLATNGG---PTLIGNGSVAAVAGGSGT---- 1371
            :...:   |....|::.|.....:...:...:.::|..||   .|:|...|  ::.||.|.
  Fly   848 NVTTT---MLTGDAVNATVTYNQINAQRAQLLAAVAAVGGGCSSTVISPSS--SILGGLGKPLGM 907

  Fly  1372 -----LRRGILRGVVGVP-------------QPDVTHHTSTVGGSPMQM---------------L 1403
                 |..|:...|:|.|             ||   .|:|.||..|..:               |
  Fly   908 GMGMGLGMGVGGTVIGSPTSLSSTATLAAHLQP---AHSSGVGTLPPGLGSGGGYILNAYASGRL 969

  Fly  1404 HDLHPVNLSASTLTTSTTLNGSLP---TATATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQLQH 1465
            |  ||.             .|.:|   |.||||           ||:..||||.......||..|
  Fly   970 H--HPP-------------GGGVPGGATHTATL-----------NRHHHQQQQLHHHPHHQQPHH 1008

  Fly  1466 QQQLLNASLVGVGVPVSAPLGS 1487
            ....|   |:|....|...:||
  Fly  1009 SGSSL---LMGSAGSVMGVVGS 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	18/105 (17%)
		Ig	300..361	CDD:299845	15/90 (17%)
		Ig	380..454	CDD:299845	16/85 (19%)
		IG_like	490..573	CDD:214653	14/82 (17%)
		Ig	501..560	CDD:299845	8/58 (14%)
		Ig	584..666	CDD:299845	21/82 (26%)
		IG_like	585..666	CDD:214653	21/81 (26%)
		I-set	678..767	CDD:254352	9/88 (10%)
		IGc2	692..757	CDD:197706	6/64 (9%)
		Ig	788..849	CDD:143165	13/60 (22%)
		Ig	885..960	CDD:143165	19/75 (25%)
		FN3	967..1051	CDD:238020	21/93 (23%)
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	18/105 (17%)
		Ig	57..160	CDD:299845	18/105 (17%)
		Ig	188..251	CDD:299845	26/163 (16%)
		Ig	289..363	CDD:299845	21/84 (25%)
		IG_like	289..351	CDD:214653	20/72 (28%)
		Ig_2	376..460	CDD:290606	20/155 (13%)
		IG_like	383..454	CDD:214653	15/71 (21%)
		Ig	470..548	CDD:299845	19/83 (23%)
		IG_like	481..557	CDD:214653	20/81 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810