DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and Il1rapl1

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_001153875.1 Gene:Il1rapl1 / 331461 MGIID:2687319 Length:696 Species:Mus musculus


Alignment Length:712 Identity:140/712 - (19%)
Similarity:229/712 - (32%) Gaps:205/712 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 ANPTPVTYKWTKDGTTIPQDGDHRIFADGG-------SLNFTRLHRDDAGIYSCSASNSQGGATL 761
            |....::..|.|  ::.|.|.:..|..||.       |:.|......|:|:|:|...||.....:
Mouse    67 AQSAGLSLMWYK--SSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKV 129

  Fly   762 NITVVVE-------YGTTIK-------SVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYD 812
            :|::.|.       |.:.:|       |.|:.|.....||.:|       |..|..:.|.:....
Mouse   130 SISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLL-------PTREPEILWYKECRT 187

  Fly   813 MTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAA 877
            ...:.|..|...|  |.||:.|.:|:||:.|  :.:......|....:...||...|.|.||...
Mouse   188 KAWRPSIVFKRDT--LLIKEVKEDDIGNYTC--ELKYGGFVVRRTTELTVTAPLTDKPPKLLYPM 248

  Fly   878 SG--------TGERGRLPCRA----QGSPKPQFIWRQDKK---DLPINRTYKYEVE--ERKIDSL 925
            ..        .|....|.|||    .|...|...|.:.:|   ||..||.::.::.  :..:...
Mouse   249 ESKLTVQETQLGGSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQ 313

  Fly   926 TYESTLIVDKVAPADYGAYECVARNELGEAVETVRL---------EITSQPDPPLSLNILNVT-- 979
            ....:||||.|...|.|.|.|...|..|....:|.|         |:.......|.|.|.:||  
Mouse   314 EVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLICSVTIY 378

  Fly   980 ---HDTVTLAWTPGF-----DGGLK--ASYRVRYRMADREQYKYIDGLPNSHKLTI--GGLRMNT 1032
               ...:.|.:...|     ||..|  .:| :.|...|.:|:....|......|.|  ..|..:.
Mouse   379 KCYKIEIMLFYRNHFGAEELDGDNKDYDAY-LSYTKVDPDQWNQETGEEERFALEILPDMLEKHY 442

  Fly  1033 LYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAG 1097
            .|...:...:.:...:|:.|:||.                                   |.....
Mouse   443 GYKLFIPDRDLIPTGTYIEDVARC-----------------------------------VDQSKR 472

  Fly  1098 IVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVA 1162
            :::|:...:|:            :||..:...|     :...|:::.|    ....:|:..|.:.
Mouse   473 LIIVMTPNYVV------------RRGWSIFELE-----TRLRNMLVTG----EIKVILIECSELR 516

  Fly  1163 WFFVHQRRKKVAETTNQPAKTATI---------------------EMYAPSSYNDTVTGE----- 1201
            ....:|.    .|......|..|:                     ||  |....:.:|.|     
Mouse   517 GIMNYQE----VEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEM--PFKRIEPITHEQALDV 575

  Fly  1202 ----------TLSSVSEKSESYSNEGSSQPE--------YIDEVRKKAASTYLVEGSDMPPPRYQ 1248
                      |:|::|..:.:.:...::.|:        |..::|:|  ..|.....|:||    
Mouse   576 SEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQK--HYYRSYEYDVPP---- 634

  Fly  1249 KDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYN 1310
             .||||:....|....|.:|....|.........|:                 |.||.::.|
Mouse   635 -TGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSNRE-----------------PNPDEAHTN 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653
Ig 197..279 CDD:299845
IG_like 296..376 CDD:214653
Ig 300..361 CDD:299845
Ig 380..454 CDD:299845
IG_like 490..573 CDD:214653
Ig 501..560 CDD:299845
Ig 584..666 CDD:299845
IG_like 585..666 CDD:214653
I-set 678..767 CDD:254352 17/69 (25%)
IGc2 692..757 CDD:197706 16/59 (27%)
Ig 788..849 CDD:143165 15/60 (25%)
Ig 885..960 CDD:143165 23/83 (28%)
FN3 967..1051 CDD:238020 20/97 (21%)
Il1rapl1NP_001153875.1 PHA02785 9..334 CDD:165149 68/279 (24%)
Ig1_IL1RAPL-1_like 32..135 CDD:143304 17/69 (25%)
Ig 148..234 CDD:299845 22/96 (23%)
IGc2 260..341 CDD:197706 23/80 (29%)
TIR 405..559 CDD:279864 27/214 (13%)
Interaction with NCS1. /evidence=ECO:0000250 549..644 20/103 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..680 6/38 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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