DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Skint2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_017175754.1	Gene:	Skint2 / 329919	MGIID:	3649629	Length:	404	Species:	Mus musculus

Alignment Length:	247	Identity:	51/247 - (20%)
Similarity:	101/247 - (40%)	Gaps:	52/247 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 GAT-LNITVVVEYGTTIKSVSENIVVNP---------GEDAMLSCTVEGKPLTEEH--VKWERVG 810
            ||| :.:.||:.:...:...||...|..         |.:..|||.: ..|...:|  ::|.|..
Mouse     6 GATGVLLCVVLHFLQMVTQSSEKFTVTGLQRPVLAPLGGNVELSCQL-SPPQQAQHMEIRWFRNR 69

  Fly   811 YDMTVKTSTTFANG--------TSYLHIKDAKREDVGN-------FRCVADNRVDNPTNRDILLI 860
            |...|   ..:.||        :.|:...:..::|:|.       |:..||   |:.:...:..:
Mouse    70 YREPV---YLYRNGKDLHGETISKYVERTELLKDDIGKGKVTLRIFKLTAD---DDGSYHCVFKV 128

  Fly   861 VKF----APEIAKTPT------LLRAASGTGERGRLPCRAQG-SPKPQFIWRQDKKDLPINRTYK 914
            .:|    ..||..|.|      |::..:..|.  .|.|.:.| .|:|...||.:|.::....:..
Mouse   129 GEFYEEHITEIKVTATSSVMYILMQPPNIKGV--MLECHSGGWFPQPHMEWRDNKGNIIPATSKA 191

  Fly   915 YEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQ 966
            :..:|.|:.::|  .||:::   .:.:.:..|..:|.|....|::.:.::.:
Mouse   192 HSQDENKLFNMT--MTLLIE---ASSHRSITCYLQNLLTHQEESISIVLSGE 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	4/9 (44%)
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165	17/77 (22%)
		Ig	885..960	CDD:143165	17/75 (23%)
		FN3	967..1051	CDD:238020	51/247 (21%)
Skint2	XP_017175754.1	Ig	155..243	CDD:386229	18/91 (20%)
		7tm_GPCRs	<199..>308	CDD:391938	7/45 (16%)
		TM helix 4	245..265	CDD:341315
		Ig_MOG_like	43..142	CDD:319291	22/105 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910