DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Igdcc3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001359088.1	Gene:	Igdcc3 / 315759	RGDID:	1307338	Length:	812	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	192/819 - (23%)
Similarity:	302/819 - (36%)	Gaps:	140/819 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   584 IEPEE--LRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQ 646
            :||.:  ...|....:.|....| ||.::||.|:|..:....:|:.  |..|::.....|:...:
  Rat    56 VEPNDDIANLGQPIMLGCKVEGS-PPVQVSWRKNGAELPEDTHTTL--LANGSLLIHHLRLEQGE 117

  Fly   647 EMNGQ-VYTCQSANE---ALQRSAHEAVSL--DVLYRPKFVPPPSSTAVGVEGESLQVSLQTRAN 705
            ..:.: .|.|.:.|.   .:.|.|...|:.  |....|:.|       :|.||...:...|....
  Rat   118 SPSDEGDYECVAQNRFGLLVSRKARIQVATMSDFHVHPQAV-------MGEEGGVARFQCQIHGL 175

  Fly   706 PTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQG-----GATLNITV 765
            |.|: ..|.|:...|..|.:.......|.|..|.|..:|:|::.|.|||...     ||.|.::.
  Rat   176 PKPL-ITWEKNRVPIDTDDERYTLLPKGVLQITGLRAEDSGVFHCVASNMASVRVSHGARLTVSG 239

  Fly   766 VVEYGT----TIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERV-GYDMTVKTSTTFANGT 825
            ... ||    ||....||:.:...:.|:|.|...|.|  ...|.|.|: |..:.|:.....  ||
  Rat   240 SGS-GTYKEPTILVGPENLTLTVHQTAVLECVATGNP--RPIVSWSRLDGRPIGVEGIQVL--GT 299

  Fly   826 SYLHIKDAKREDVGNFRCVADNRVDNPTNRDI--LLIVKFAPEIAKTPTLLRAASGTGERGRLPC 888
            ..|.|.|...:..|.:.|.| ||......|..  .|:|:...|..:.|..:...:||  .....|
  Rat   300 GNLIISDVTVQHSGVYVCAA-NRPGTRVRRTAQGRLVVQAPAEFVQHPQSISRPAGT--TAMFTC 361

  Fly   889 RAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG 953
            :|||.|.|...|.::.:.|......:.:         ...|||.:..|.|.|...|:|||.|..|
  Rat   362 QAQGEPPPHVTWLKNGQVLGAGGHVRLK---------NNNSTLSISGVGPEDEAIYQCVAENIAG 417

  Fly   954 EAVETVRLEI---TSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLK-ASYRVRYR-MADREQYKY 1013
            .:..:.||.:   ...|.||.::..::|:...|.::|:.......: ..|.:..| .||..:.:|
  Rat   418 SSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLTHTKEIIGYVLHIRKAADSPKLEY 482

  Fly  1014 IDGLPNS-HKLTIGGLRMNTLYLFSVMSWNELGQS-SYLPDLARAETKEAP-PPSHPASSLGGGP 1075
            .:.:..| .:..:..|..:|.|.|.:.::...|.| :.:|.|| :...||| ||......||...
  Rat   483 QEAVSKSTFQHLVRDLEPSTAYSFYIKAYTPRGASLASVPTLA-STLGEAPVPPPLSVRLLGSSS 546

  Fly  1076 --------PTTSQTPLGG-------------TSGMLLVGVGAGIVVVLLN---VFVIGCCLHKRN 1116
                    |..:|.. ||             |..:||.|..:...:..|:   |:.:....:.:|
  Rat   547 LQLLWKPWPRLAQHN-GGFKLFYRPASAASFTGPILLPGTVSSYNLSQLDPSTVYEVKLLAYNQN 610

  Fly  1117 EK--------RLKRGLE---LMP------AELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWF 1164
            ..        .||...|   |.|      .|:|..:|.|.  ::|||.:.....:.    .|.:.
  Rat   611 GDGNATVRFVSLKGASERTALTPPCDCRKEEVTNHTSTTG--IVIGIHIGVTCIIF----CVLFL 669

  Fly  1165 FVHQRRK----KVAETTNQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSS---QPE 1222
            ...||.:    |..|....|.:       .|.|..|... .||:.|:.      .||..   ..:
  Rat   670 LFGQRGRVLLCKDVENQLSPPQ-------GPRSQRDPGI-LTLNGVNR------GEGGQLGRDEK 720

  Fly  1223 YIDEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQM 1287
            ::|  .|:....:....|...|.....|.|.|..|....::...|    .:...||...|  :.|
  Rat   721 HVD--AKELEQLFPTTASAGQPGSRSTDPTAPTPYEETQLSMVQL----QDFNLAAGRTT--ETM 777

  Fly  1288 LISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPA 1326
            ....|   |.|.||....|  ..:.|||..: .|:..||
  Rat   778 SSCAG---PGPVPASQDVG--LGLLSDRQTA-QPLAVPA 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	19/87 (22%)
		IG_like	585..666	CDD:214653	19/86 (22%)
		I-set	678..767	CDD:254352	25/93 (27%)
		IGc2	692..757	CDD:197706	19/64 (30%)
		Ig	788..849	CDD:143165	19/61 (31%)
		Ig	885..960	CDD:143165	20/74 (27%)
		FN3	967..1051	CDD:238020	18/87 (21%)
Igdcc3	NP_001359088.1	Ig	54..145	CDD:386229	20/91 (22%)
		Ig	153..237	CDD:386229	25/91 (27%)
		IG_like	254..336	CDD:214653	24/86 (28%)
		I-set	341..427	CDD:369462	26/96 (27%)
		FN3	434..527	CDD:238020	21/93 (23%)
		fn3	<554..613	CDD:365830	11/59 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910