DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Fas2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	848	Identity:	179/848 - (21%)
Similarity:	288/848 - (33%)	Gaps:	273/848 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 PLISGY--MEGQIIPAGSVQKLLCVSSGGNP--LATLTWYKNDKRINSVIRAAD----------- 532
            |::..|  .|.|..|.|....|.|..:...|  :|.|.|  .|.|.|:::...:
  Fly    31 PILEIYPKQEVQRKPVGKPLILTCRPTVPEPSLVADLQW--KDNRNNTILPKPNGRNQPPMYTET 93

  Fly   533 ---KSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRP--G 592
               :|::..||.|:  .:...:|.|.||.:.||| |.:..|:..:.|   :.....||...|  |
  Fly    94 LPGESLALMITSLS--VEMGGKYYCTASYANTEI-LEKGVTIKTYVA---ITWTNAPENQYPTLG 152

  Fly   593 MEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQS 657
            .:..::|: ..::|...:.|.::|.||...|:..       .|.|....:...||.:..:|||::
  Fly   153 QDYVVMCE-VKADPNPTIDWLRNGDPIRTTNDKY-------VVQTNGLLIRNVQESDEGIYTCRA 209

  Fly   658 A----NEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGT 718
            |    .|.|:|:    :.::|..:|:.:..|::.. .|||:....:...|..|.| ...|.:|.|
  Fly   210 AVIETGELLERT----IRVEVFIQPEIISLPTNLE-AVEGKPFAANCTARGKPVP-EISWIRDAT 268

  Fly   719 TI-----------PQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTT 772
            .:           ||.         |.:..:.:.:||.|.|:|.|.|..|        ||:..|.
  Fly   269 QLNVATADRFQVNPQT---------GLVTISSVSQDDYGTYTCLAKNRAG--------VVDQKTK 316

  Fly   773 IKSVSENIVVNP------------GEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANG- 824
            :     |::|.|            .::..::|..:|:|...  :.:.|.|      |...:.||
  Fly   317 L-----NVLVRPQIYELYNVTGARTKEIAITCRAKGRPAPA--ITFRRWG------TQEEYTNGQ 368

  Fly   825 --------------------TSYLHIKDAKREDVGNFRCVADNRVDNPTNRDIL----LIVKFAP 865
                                |..|.|.:|:|.|.|.::|:|.|:     ..|..    :.|:|||
  Fly   369 QDDDPRIILEPNFDEERGESTGTLRISNAERSDDGLYQCIARNK-----GADAYKTGHITVEFAP 428

  Fly   866 EIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWR---QDKKDLPINRTYKYEVEERKIDSLTY 927
            :.:....|....|....:..|.|.|.|.|.....|.   :..|||       |:. ..||.....
  Fly   429 DFSHMKELPPVFSWEQRKANLSCLAMGIPNATIEWHWNGRKIKDL-------YDT-NLKIVGTGP 485

  Fly   928 ESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPD-----PPLSLNILNVTHD------ 981
            .|.|||..|....|..|:|:|.|..|.|...::|:....||     .|..|....:|.|
  Fly   486 RSDLIVHPVTRQYYSGYKCIATNIHGTAEHDMQLKEARVPDFVSEAKPSQLTATTMTFDIRGPST 550

  Fly   982 ---TVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNE 1043
               ...||::..:...|...:...|..:......||          :.|||..|.|.|...:.|:
  Fly   551 ELGLPILAYSVQYKEALNPDWSTAYNRSWSPDSPYI----------VEGLRPQTEYSFRFAARNQ 605

  Fly  1044 LG-------QSSYLPDLARAETKEAPPPSH--------------PAS---SLGGGPPTTSQTPL- 1083
            :|       |....|   |....|.|.|.|              |.|   .|..|.|..:..|:
  Fly   606 VGLGNWGVNQQQSTP---RRSAPEEPKPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEPID 667

  Fly  1084 ----------------------------------------GGT---------------------- 1086
                                                    |.|
  Fly   668 RYQIKYCPGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIGYSSPASIIM 732

  Fly  1087 -----------------SGMLLVGVGAGIVVVLLNVFVIGCCL--HKRNEKRLKRGLELMPAELT 1132
                             |...:||:..|.|::||.|..:.||:  |......:.|..:..|:|:.
  Fly   733 KTTRGIDVIQVAERQVFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMATMCRKAKRSPSEID 797

  Fly  1133 EDS 1135
            :::
  Fly   798 DEA 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	26/98 (27%)
		Ig	501..560	CDD:299845	17/74 (23%)
		Ig	584..666	CDD:299845	22/87 (25%)
		IG_like	585..666	CDD:214653	22/86 (26%)
		I-set	678..767	CDD:254352	22/99 (22%)
		IGc2	692..757	CDD:197706	18/75 (24%)
		Ig	788..849	CDD:143165	18/81 (22%)
		Ig	885..960	CDD:143165	24/77 (31%)
		FN3	967..1051	CDD:238020	21/104 (20%)
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	26/98 (27%)
		IG_like	144..226	CDD:214653	22/93 (24%)
		IGc2	152..209	CDD:197706	15/64 (23%)
		I-set	230..319	CDD:254352	25/112 (22%)
		IGc2	243..309	CDD:197706	18/75 (24%)
		IG_like	330..424	CDD:214653	19/106 (18%)
		IGc2	339..412	CDD:197706	17/80 (21%)
		Ig	447..518	CDD:143165	24/78 (31%)
		fn3	534..611	CDD:278470	17/86 (20%)
		FN3	640..735	CDD:238020	8/94 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910