DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and kirre

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	1183	Identity:	236/1183 - (19%)
Similarity:	379/1183 - (32%)	Gaps:	412/1183 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RRCRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQK------------------------------ 73
            :|.|...:..|.|: |:.::.|...|:..||:.:|
  Fly     2 KRMRSSRLLVLPLI-LVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAA 65

  Fly    74 ------------------FRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGF 120
                              |...|.|...:.|:...:.|.|....||:|||||.|.||....:.||
  Fly    66 SSANDESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLSGF 130

  Fly   121 PRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPA-RLNSAIRAN-AKLTVISPPASIEIKGYS 183
            .|||::|..::|.::|.|....::|||.|||||||. :....||:. |||||:.||.:.:|   :
  Fly   131 ERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKI---T 192

  Fly   184 HNSKVEVRENQDLQLKCIVANAKPAAQIVWYRG-------NVEYKPEKREDTVEESTAKRFTTTS 241
            ....:...|:::::|:|:....||||:|.|..|       .:||..|...|      ::|.|..|
  Fly   193 QGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLAD------SRRITARS 251

  Fly   242 SLKLKPGPDDDYTEYTCQARHKALSPDMPMR-ATVQLSVLYPPG--PPYIEGYSAGETLRRGQTV 303
            .|||.|..:...|.:||||::.|   |...| |.:.|.|.|.|.  ...:.|..||..:..|..|
  Fly   252 ILKLAPKKEHHNTTFTCQAQNTA---DRTYRSAKLLLEVKYAPKVIVSVVGGALAGGKIPEGAEV 313

  Fly   304 ELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVM--SQN 366
            .|.|::..........|:.|...:      :|..:..:.........:.|..:||..|.:  |:.
  Fly   314 ILSCQADANPHELSYRWFINDELM------TGDFTTKMIIHNVSRQYHDAIVKCEVVNAVGKSEQ 372

  Fly   367 PLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVS 431
            ..|.::....:|....|:|    ||.:|..|.:.|..| .||..||:|
  Fly   373 SKKLDISFGPVFRQRPVSV----EADLGATVSMRCDVA-GNPEPEIEW----------------- 415

  Fly   432 PEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTH----TIN---------VLYPPAPP 483
                          :..|...:|.:...|.::::......:    .:|         .||....|
  Fly   416 --------------ISENSDQVVGVAAELKLKVSSETAGRYFCKAVVNGFPEIGAEATLYVKRAP 466

  Fly   484 LISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDN 548
            :|:.: :.|....|...|:.|::........:.|....|.||
  Fly   467 IITSH-KVQFGGVGGRVKIDCLAFSIPKAEHILWSFEGKIIN----------------------- 507

  Fly   549 QAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSS-----NPPA 608
                   .|::..:|.:|:.     |..||.|:            .|.||.||.::     |...
  Fly   508 -------MSSADPDIYIFEE-----HHLPEGVR------------AALIIRDSKATHFGKYNCTV 548

  Fly   609 KLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLD 673
            ..|:..|.:.|..:.   :||           .:.|...:.|.:: |.:....:       |.:.
  Fly   549 MNSYGGDSLVITLLR---EPG-----------NIPVLLVVMGSMF-CVAIILMI-------VMII 591

  Fly   674 VLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFT 738
            ::||.:                     ::|..|.|        ...||:
  Fly   592 IVYRKR---------------------RSRKKPMP--------ADVIPE---------------- 611

  Fly   739 RLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEH 803
                           .|:||..||     |..:.::|.:.::..:......|:..:...|:.:..
  Fly   612 ---------------ASRGGDKLN-----ELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDVQ 656

  Fly   804 VKWERVGYDMT--VKTSTTFA---NGTSY---LHIKDAKREDVGNFRCVADNRVDNPTNRDILLI 860
            :|...:|..:.  ||....|:   .|..|   .|||:.|.:....::
  Fly   657 MKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKNLKNQQETAYK------------------ 703

  Fly   861 VKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSL 925
                                           |||:.              ..|.:..|
  Fly   704 -------------------------------GSPQA--------------NGYAHYFE------- 716

  Fly   926 TYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTL--AWT 988
                 ..:|...|...||...|....:|:....             .:|...:.|.....  ...
  Fly   717 -----YALDYSPPGGEGAAVVVGSGGVGKLKNG-------------GMNSATLPHSAAATVNGGG 763

  Fly   989 PGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGL--RMNTLYLFSVMSWNELGQSSYLP 1051
            .|..||.......|:.:...:|.....|.|    |...|:  |.:.:|....:..|    ||.||
  Fly   764 AGNGGGASLPRNQRHEIQQSQQSNGFLGQP----LLQNGIDSRFSAIYGNPYLRTN----SSLLP 820

  Fly  1052 DL-----ARAETKEAPPPSHPASS-------------LGGGPPTTS--------------QTPLG 1084
            .|     |......||||.|.|..             :||...|||              .||.|
  Fly   821 PLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKHFVGGAVITTSPVGNVNINGGGGGGSTPSG 885

  Fly  1085 GTSGMLLVGVGAG 1097
            |  |.:.|||.||
  Fly   886 G--GGVGVGVAAG 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	41/146 (28%)
		Ig	76..155	CDD:299845	32/78 (41%)
		IG_like	186..279	CDD:214653	31/100 (31%)
		Ig	197..279	CDD:299845	30/89 (34%)
		IG_like	296..376	CDD:214653	13/81 (16%)
		Ig	300..361	CDD:299845	10/60 (17%)
		Ig	380..454	CDD:299845	14/73 (19%)
		IG_like	490..573	CDD:214653	11/82 (13%)
		Ig	501..560	CDD:299845	7/58 (12%)
		Ig	584..666	CDD:299845	14/86 (16%)
		IG_like	585..666	CDD:214653	14/85 (16%)
		I-set	678..767	CDD:254352	10/88 (11%)
		IGc2	692..757	CDD:197706	6/64 (9%)
		Ig	788..849	CDD:143165	13/68 (19%)
		Ig	885..960	CDD:143165	11/74 (15%)
		FN3	967..1051	CDD:238020	16/87 (18%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	40/95 (42%)
		IG_like	88..182	CDD:214653	39/93 (42%)
		C2-set_2	189..279	CDD:285423	29/101 (29%)
		Ig_2	307..379	CDD:290606	13/77 (17%)
		I-set	382..462	CDD:254352	19/115 (17%)
		IGc2	396..446	CDD:197706	12/81 (15%)
		Ig	466..561	CDD:299845	26/142 (18%)
		IG_like	478..561	CDD:214653	23/129 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451324
Domainoid	1	1.000	42	1.000	Domainoid score	I8442
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950