DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Mdga1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006256269.1	Gene:	Mdga1 / 309659	RGDID:	1307031	Length:	956	Species:	Rattus norvegicus

Alignment Length:	936	Identity:	212/936 - (22%)
Similarity:	326/936 - (34%)	Gaps:	284/936 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 TLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAE--AGDNKARFRCE 358
            |:|...|:.|.|... |:|..|:.|.|........::.:...:|   |...|  |.....|:.|:
  Rat    49 TIRESDTLVLQCLVT-GHPRPQVRWTKTAGSASDKFQETSVFNE---TLRIERIARTQGGRYYCK 109

  Fly   359 ASNVMSQNPLKA-EVELSVLFAP---THVTVMGPTEARVGDI-----VPLTCTTAPSNPPAEIKW 414
            |.|.:....:|: .|::..|..|   .|.||   ::.| |:.     |.|.||.: |||||...|
  Rat   110 AENGVGVPAIKSIRVDVQYLDEPVLTVHQTV---SDVR-GNFYQEKTVFLRCTVS-SNPPARFIW 169

  Fly   415 MVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYP 479
                                               ||....:.|.     .:|.|.      :|.
  Rat   170 -----------------------------------KRGSDTLSHS-----QDNGVD------IYE 188

  Fly   480 PAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILAN 544
            |.      |.:|:.    .|.||                ||       :|..|
  Rat   189 PL------YTQGET----KVLKL----------------KN-------LRPQD------------ 208

  Fly   545 VSDNQAQYRCEAS-NSATEIP----LFQSTTLSVHFAPETVKIRI-EPEELRPGMEATIICDSSS 603
                .|.|.|:.| .:...||    .||.|..:   ||.|:|:.: |...:.||...|:.|..:.
  Rat   209 ----YASYTCQVSVRNVCGIPDKSITFQLTNTT---APPTLKLSVNETLVVNPGENVTVQCLLTG 266

  Fly   604 SNPPAKLSWWKDG---IPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRS 665
            .:|..:|. |..|   :|:..:..       |||:|     :...|..:...|.|.:.|. :...
  Rat   267 GDPLPQLH-WSHGPGPLPLGALAQ-------GGTLS-----IPSVQARDSGYYNCTATNN-VGNP 317

  Fly   666 AHEAVSLDVLYRP------KFVPPPSSTAVGVE-GESLQVSLQTRANP-TPVTYKWTKDG----- 717
            |.:.|:|  |.|.      :..|.....:..:: |:.|::|....|.| ..|.|:|.|:|
  Rat   318 AKKTVNL--LVRSLKNATFQITPDMIKESENIQLGQDLKLSCHVDAVPQEKVNYQWFKNGKPART 380

  Fly   718 --TTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSAS---------------NSQGGATLNITV 765
              ..:....|..:.|...||....||..|.|.|.|.||               :|:   |:..|:
  Rat   381 SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCVASFPGSPVPDLSVEVNISSE---TVPPTI 442

  Fly   766 VVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGT--SYL 828
            .|..|..:.:|.|      |..|.|.|.|.|||  ...|.|.||..:..:..|......|  ..|
  Rat   443 SVPKGRAVVTVRE------GSPAELQCEVRGKP--RPPVLWSRVDKEAALLPSGLALEETPDGKL 499

  Fly   829 HIKDAKREDVGNFRC-VADNRVDNPTNRD--ILLIVKFAPEIAKTPTLLRAASGTGERGRLPCR- 889
            .::...||..|.:|| .|.....|...|:  :.|.|.|.||:..:...:|.|  .|....|.|.
  Rat   500 RVERVSREMSGTYRCQTARYNGFNVRAREAQVQLTVHFPPEVEPSSQDVRQA--LGRPVLLRCSL 562

  Fly   890 AQGSPK--PQFIWR------QDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYEC 946
            .:|||:  ...:||      .....||.......:..|.::|:||.:|:           |.|||
  Rat   563 LRGSPQRIASAVWRFKGQLLPPPPVLPAAAAEGPDHAELRLDALTRDSS-----------GNYEC 616

  Fly   947 VARNELGEAVETVRLEITSQ----------PDP----PLSLNILNVTHDTVTLAWT----PGFDG 993
            ...|::|.|  |...:::::          |:|    .||.|.      :..|.||    ...|.
  Rat   617 SVSNDVGSA--TCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNY------SYVLQWTQREPDAVDP 673

  Fly   994 GLKASYRVRYRMADRE------------------QYKYID-GLPNSHKLTI--------GGLRMN 1031
            .|  :||:..|..::.                  :|...| .:|:|:::.:        |.:...
  Rat   674 VL--NYRLSIRQLNQHNAMVKAIPVRRVEKGQLLEYTLTDLRVPHSYEIHLTPYTTFGAGDMASR 736

  Fly  1032 TLYLFSVMSWNELGQSS----------YLPDLAR--AETKEAPPPSHPASSLGGGPPT-TSQTPL 1083
            .::....::...|..::          |..||..  ..|::.....:|..|...|||| .|.||.
  Rat   737 VIHYTEPINSPSLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGTPE 801

  Fly  1084 G-----GTSGMLLVGVGAGIVVVLLN 1104
            |     .||....:|..|.:|..|.|
  Rat   802 GYYMFIETSRPRELGDRARLVSPLYN 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	20/82 (24%)
		Ig	300..361	CDD:299845	15/62 (24%)
		Ig	380..454	CDD:299845	18/81 (22%)
		IG_like	490..573	CDD:214653	17/87 (20%)
		Ig	501..560	CDD:299845	10/59 (17%)
		Ig	584..666	CDD:299845	18/85 (21%)
		IG_like	585..666	CDD:214653	18/83 (22%)
		I-set	678..767	CDD:254352	26/118 (22%)
		IGc2	692..757	CDD:197706	23/88 (26%)
		Ig	788..849	CDD:143165	20/63 (32%)
		Ig	885..960	CDD:143165	22/83 (27%)
		FN3	967..1051	CDD:238020	20/128 (16%)
Mdga1	XP_006256269.1	IG_like	46..126	CDD:214653	20/80 (25%)
		Ig	56..115	CDD:299845	15/62 (24%)
		IG_like	152..217	CDD:214653	29/160 (18%)
		Ig	153..217	CDD:143165	29/159 (18%)
		IG_like	248..326	CDD:214653	21/93 (23%)
		IGc2	254..315	CDD:197706	17/74 (23%)
		IGc2	350..418	CDD:197706	20/67 (30%)
		IG_like	450..535	CDD:214653	26/92 (28%)
		Ig	459..535	CDD:299845	23/77 (30%)
		Ig	541..623	CDD:299845	22/94 (23%)
		IG_like	543..632	CDD:214653	25/103 (24%)
		MAM	754..918	CDD:279023	21/74 (28%)
		MAM	754..917	CDD:99706	21/74 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910