DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and cntn2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_571521.1	Gene:	cntn2 / 30726	ZFINID:	ZDB-GENE-990630-12	Length:	1040	Species:	Danio rerio

Alignment Length:	1065	Identity:	228/1065 - (21%)
Similarity:	356/1065 - (33%)	Gaps:	311/1065 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 SLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLT 516
            |.:.:.:.|...:.|   |.|....::...|..:. |.||  :|.|.|  .|...:..:|.|...
Zfish    13 SFLALSNALGGDVCE---SGHDSGPVFEEQPSSLI-YPEG--MPEGKV--TLGCQARSSPAAVYR 69

  Fly   517 WYKNDKRINSV-IRAADKSVSAEITILANVSDNQAQ-------YRCEASNSATEIPLFQSTTLSV 573
            |     |:|.. |..|::|...::.  .|:..|..|       |:|.|.|....| :.:...|..
Zfish    70 W-----RVNGTDISFAEESHYTQVA--GNLVINNPQNGRDGGSYQCLAINRCGTI-VSRVANLKF 126

  Fly   574 ----HFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKP--GLW- 631
                .|.||:    ..|:.:..||...:.|...:..|.....|:.:..|     |..:|  |.|
Zfish   127 GYLRDFPPES----RSPQTVHEGMGTFLACQPPAHYPALSYRWFINEFP-----NFIQPEAGRWF 182

  Fly   632 ----GGTVSTLEFRVNVT------QEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPP--- 683
                .|.:.....|.|.|      ..:|..|.|....::|:|.:.|...|      |:...|
Zfish   183 VSQVTGNLYLANARANDTGNYFCFTTINMDVSTKSIFSKAVQLTVHPDAS------PRKTAPNIR 241

  Fly   684 ---PSSTAVGVEGESLQVSLQTRANPTPVTYKWTK-DGTTIPQDGDHRIFADGGSLNFTRLHRDD 744
               |:.| ..:.|::.|:......||.| ..:|.| ||...|:.|..   .||..|....|:.||
Zfish   242 VRFPAET-YALSGQTAQLECFAYRNPIP-KIRWRKVDGILPPKVGTS---VDGPILIIPELNFDD 301

  Fly   745 AGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERV 809
            .|:|.|...||:|..|....|.|:.......|..:..|....:...||...|||  ...::|.|.
Zfish   302 EGMYECEVYNSEGRETHQGRVSVQAQPDWLQVMSDSEVEISSELQWSCAAAGKP--RPTIRWLRN 364

  Fly   810 GYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLL 874
            |:.:..:......||.  |.|.:...||.|.::|||:|:.....:...|.:...||:....|...
Zfish   365 GHALITQDRVEVNNGR--LKIANLALEDSGMYQCVAENKHSTIYSNAELRVQVQAPDFRLNPVRK 427

  Fly   875 RAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPA 939
            ...:..|.:.::.|:.:.:|||...|.:. .:|..|.|        :| ::|.:..|.:..::.|
Zfish   428 LVPAARGGQVKMECKPRAAPKPTLFWSRG-TELLTNST--------RI-TVTPDGILWIYNISRA 482

  Fly   940 DYGAYECVARNELGEAVETVRLEI----------------------------------------- 963
            |.|.|.|.|.|.||:|..|..|.:
Zfish   483 DEGKYTCFAENYLGKANSTGHLSVRDATKITLAPSNADINQGENATLQCHASHDPTMDLTFTWSL 547

  Fly   964 -----------------------------------------TSQ-----------------PDPP 970
                                                     |:|                 |.||
Zfish   548 NGVPLDLEEPNGHYRRMEGKETIGDLVIVNGQLSHAGTYTCTAQTVVDSAMASAKLVVRGPPGPP 612

  Fly   971 LSLNILNVTHDTVTLAWTPGFDGGLK-ASYRVRYRMADREQYK-------YIDGLPNSHKLTIGG 1027
            ..|.:.:|...:|.|.|:.|:|.... ..|.:..|.:....:|       .|:|  |:....:..
Zfish   613 GGLVVTSVNDTSVELRWSRGYDNHSPIGKYVILGRSSQTHDWKRMRTDPANIEG--NAESARVID 675

  Fly  1028 LRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQ-----TPL---- 1083
            ||....|.|.|::.|.||.........||:||||.|...| |.||||....::     ||:
Zfish   676 LRPWMDYEFQVIASNILGSGEPSMPSPRAQTKEAAPTVAP-SGLGGGGGNRNELIITWTPMAREY 739

  Fly  1084 --GGTSGMLLV----GVGAGIVVVLLNV----FVIG-------CCLHKRNEKRLKRG----LELM 1127
              |.:.|.:|.    |:....||.:.||    :|..       |....|.:...|:|    .::.
Zfish   740 QNGDSFGYILAFRKQGIPTWTVVKVPNVESSRYVYSNDSLTAYCPFEVRIKAYNKKGEGPFSQIA 804

  Fly  1128 PAELTEDSSNTPNLVIIGISLAAFGF---------LLVNASL----VAWFFVHQRRKKVAETTNQ 1179
            .....|:........|...:|.||..         |.:|..|    :.::..|:|     |....
Zfish   805 VVHSAEEEPTVSPRWINATALTAFEIQVSWEPIQHLNINGVLRGYEIRYWRQHER-----EAAAD 864

  Fly  1180 PAKTATIEMYAPSSYNDTVTG---ETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSD 1241
            ..:||.:|..|      .|||   .||..::..:.:.:..|.:.|. ...:.||
Zfish   865 RVRTAGLENTA------RVTGLRPNTLYHITVLAYNSAGTGPASPR-TTVITKK----------- 911

  Fly  1242 MPPPR-------YQKDGT--------------------LPVIYPNNVVNA----------CTLPH 1269
             |||.       ::.||:                    ..|:|.:...:|          ..||.
Zfish   912 -PPPNRPPGNVSWKVDGSWVTVRWDHVKSMDNESAVLGYKVLYKHEGQSALKVLEKSKTSVKLPL 975

  Fly  1270 PRHN------------NGSAAIHMT 1282
            |:.|            .|..|.|.|
Zfish   976 PKDNGYVVLEIRSWGDGGDGAAHET 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	1/1 (100%)
		IG_like	490..573	CDD:214653	23/90 (26%)
		Ig	501..560	CDD:299845	16/66 (24%)
		Ig	584..666	CDD:299845	20/94 (21%)
		IG_like	585..666	CDD:214653	20/93 (22%)
		I-set	678..767	CDD:254352	29/95 (31%)
		IGc2	692..757	CDD:197706	22/65 (34%)
		Ig	788..849	CDD:143165	19/60 (32%)
		Ig	885..960	CDD:143165	22/74 (30%)
		FN3	967..1051	CDD:238020	24/91 (26%)
cntn2	NP_571521.1	Ig1_Contactin-2	33..126	CDD:143258	25/105 (24%)
		I-set	34..125	CDD:254352	24/103 (23%)
		Ig	128..225	CDD:299845	22/105 (21%)
		IG_like	138..227	CDD:214653	20/93 (22%)
		Ig	238..325	CDD:299845	28/91 (31%)
		IG_like	245..324	CDD:214653	27/83 (33%)
		Ig	329..413	CDD:299845	22/87 (25%)
		IG_like	335..413	CDD:214653	21/81 (26%)
		IG_like	429..506	CDD:214653	24/86 (28%)
		Ig5_Contactin_like	434..506	CDD:143170	24/81 (30%)
		I-set	511..605	CDD:254352	2/93 (2%)
		Ig6_Contactin-2	525..606	CDD:143262	2/80 (3%)
		FN3	615..702	CDD:238020	21/88 (24%)
		FN3	714..806	CDD:238020	21/92 (23%)
		FN3	817..909	CDD:238020	21/103 (20%)
		FN3	917..1002	CDD:238020	13/84 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910