DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Il1rapl2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001159814.1	Gene:	Il1rapl2 / 300913	RGDID:	1561761	Length:	686	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	67/321 - (20%)
Similarity:	121/321 - (37%)	Gaps:	60/321 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   687 TAVGVEGESLQVS-------LQTR---ANPTPVTYKWTKDGTTIPQD---GDHRIFADGGSLNFT 738
            |.:.:.||.::|.       ::|.   |..|.:...|.::...:.:.   .:.|:..:..::.|.
  Rat    40 TYMALAGEPVRVKCALFYSYIRTNYSMAQSTGLRLMWYRNKGDLEEPIIFSEVRMSKEEDAIWFH 104

  Fly   739 RLHRDDAGIYSCSASNSQGGATLNITVVVE-------YGTTIKSVSENIVVNPGEDAMLSCTVEG 796
            .....|:|.|:|...||.....:::::.|.       |.:.|:.:.::.|....|   :||....
  Rat   105 SAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKE---ISCPDMD 166

  Fly   797 ---KPLTEEHVKWERVGYDMTVK--TSTTFANGTSYLHIKDAKREDVGNFRC---VADNRVDNPT 853
               |...|..|.|.:   :...|  .|.....|.:.| |::.:.||.||:.|   .....|...|
  Rat   167 DFKKSDQEPDVVWYK---ECKPKMWRSIIIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTT 227

  Fly   854 NRDILLIVKFAP-----EIAKTPTLLRAASGTGERGRLPCRA----QGSPKPQFIWRQDKKDLP- 908
            ...:..::...|     .:...|:::...  .|:...:||:|    .|...|...|.:.:|.:.
  Rat   228 ELKVTALLTDKPPKPLFPMENQPSVIDVQ--LGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEE 290

  Fly   909 ----IN----RTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRL 961
                |.    |..|..:.|:::     |.|||.|.|..||...|.|...|..|....:|.|
  Rat   291 LAGHIREGEIRLLKEHLGEKEV-----ELTLIFDSVVEADLANYTCHVENRNGRKHASVLL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	16/92 (17%)
		IGc2	692..757	CDD:197706	15/77 (19%)
		Ig	788..849	CDD:143165	16/68 (24%)
		Ig	885..960	CDD:143165	23/87 (26%)
		FN3	967..1051	CDD:238020
Il1rapl2	NP_001159814.1	Ig1_IL1RAPL-1_like	32..133	CDD:143304	16/92 (17%)
		IG_like	39..133	CDD:214653	16/92 (17%)
		Ig2_IL1R_like	146..237	CDD:143234	21/97 (22%)
		IG_like	159..231	CDD:214653	19/78 (24%)
		IG_like	250..347	CDD:214653	27/104 (26%)
		Ig	261..344	CDD:143165	23/87 (26%)
		TIR	401..559	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910