DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and Crtam

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:XP_038936973.1 Gene:Crtam / 300649 RGDID:1304602 Length:389 Species:Rattus norvegicus


Alignment Length:233 Identity:49/233 - (21%)
Similarity:85/233 - (36%) Gaps:49/233 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 VEVRENQDLQLKCIVANAK--------PAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLK 244
            :||.|.|.|.|.|:.:..|        |:...::...:...|..|.: .:..|..:...:.|::.
  Rat    24 IEVEEGQTLNLTCVTSLTKNASLQWLAPSGFTIFLNQHPALKSSKYQ-LLHHSATQLSVSVSNVT 87

  Fly   245 LKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRR---GQTVELM 306
            |:     :...|||.....::....     |:::||..|..|.:|..    .|||   .::|.|.
  Rat    88 LR-----EEGVYTCLHYGSSVKTKQ-----VRVTV
LVTPFQPTVEAL----VLRRQNGEKSVVLK 138

  Fly   307 CRSRGGNPPAQLIWYKNG-----SQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQN 366
            |.:....||.|:.|...|     .::...:...|::|....|....:....:...|    |:...
  Rat   139 CSTERSKPPPQVTWLLGGGLEIDGELHHEFEADGKISNTTSTLVVRSYGKNSTVHC----VIRHK 199

  Fly   367 PLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA 404
            .|:..    .|.||          .|.||:|....||:
  Rat   200 GLQGR----K
LVAP----------FRFGDLVADQETTS 223

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653 18/98 (18%)
Ig 197..279 CDD:299845 13/89 (15%)
IG_like 296..376 CDD:214653 17/87 (20%)
Ig 300..361 CDD:299845 12/65 (18%)
Ig 380..454 CDD:299845 7/25 (28%)
IG_like 490..573 CDD:214653
Ig 501..560 CDD:299845
Ig 584..666 CDD:299845
IG_like 585..666 CDD:214653
I-set 678..767 CDD:254352
IGc2 692..757 CDD:197706
Ig 788..849 CDD:143165
Ig 885..960 CDD:143165
FN3 967..1051 CDD:238020
CrtamXP_038936973.1 Ig 22..112 CDD:416386 18/98 (18%)
FR1 22..37 CDD:409353 6/12 (50%)
Ig strand A' 22..28 CDD:409353 2/3 (67%)
Ig strand B 30..38 CDD:409353 4/7 (57%)
CDR1 38..43 CDD:409353 0/4 (0%)
FR2 44..51 CDD:409353 0/6 (0%)
Ig strand C 44..50 CDD:409353 0/5 (0%)
CDR2 52..63 CDD:409353 0/10 (0%)
Ig strand C' 54..58 CDD:409353 0/3 (0%)
Ig strand C' 60..63 CDD:409353 0/2 (0%)
FR3 64..99 CDD:409353 8/40 (20%)
Ig strand D 68..75 CDD:409353 1/7 (14%)
Ig strand E 78..84 CDD:409353 0/5 (0%)
Ig strand F 91..99 CDD:409353 3/7 (43%)
CDR3 100..103 CDD:409353 0/2 (0%)
Ig strand G 103..112 CDD:409353 1/13 (8%)
FR4 105..112 CDD:409353 1/11 (9%)
C2-set_2 119..205 CDD:400489 19/97 (20%)
Ig strand B 135..142 CDD:409353 3/6 (50%)
Ig strand C 147..155 CDD:409353 3/7 (43%)
Ig strand C' 157..159 CDD:409353 0/1 (0%)
Ig strand D 161..168 CDD:409353 0/6 (0%)
Ig strand E 173..181 CDD:409353 1/7 (14%)
Ig strand F 191..198 CDD:409353 2/10 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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