DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Hepacam

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_038938232.1	Gene:	Hepacam / 300517	RGDID:	1306811	Length:	418	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	85/376 - (22%)
Similarity:	139/376 - (36%)	Gaps:	117/376 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 LNITVVVE--YGTTIKSVSENIVVNPGEDAML----SCTVEGKPLTEEHVKW-----------ER 808
            :|||..|.  :||.            |:.|:|    |.|...||:    |||           :.
  Rat    34 VNITSPVRLIHGTV------------GKSALLSVQYSSTSSDKPV----VKWQLKRDKPVTVVQS 82

  Fly   809 VGYDM--TVKTS-----TTFANGTSYLHIKDAKREDVGNFR---CVADN----------RVDNPT 853
            :|.::  |::..     ..|.||:  |.:.|.:..|.|.:.   .:.|:          .||.|.
  Rat    83 IGTEVIGTLRPDYRDRIRLFENGS--LLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPI 145

  Fly   854 NRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVE 918
            :|..:|:.        :.|:|..:    |...|.|..:...||.:.|.:|.|.| :|.:......
  Rat   146 SRPQVLVA--------STTVLELS----EAFTLNCSHENGTKPSYTWLKDGKPL-LNDSRMLLSP 197

  Fly   919 ERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNI------LN 977
            ::|:        |.:.:|...|...|.||..|.:.: |.::.::||......|.:.:      |.
  Rat   198 DQKV--------LTITRVLMEDDDLYSCVVENPISQ-VRSLPVKITVYRRSSLYIILSTGGIFLL 253

  Fly   978 VTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYI-----------DGLPNSHKLTIGGLRMN 1031
            ||..||...|.|.     |.| |.:.::..:...:|:           |.||.|.:..    |.|
  Rat   254 VTLVTVCACWKPS-----KKS-RKKRKLEKQNSLEYMDQNDDRLKSEADTLPRSGEQE----RKN 308

  Fly  1032 TLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTP 1082
            .:.|:            .|.|...:|..| .|.:.|.|:...|||..|.:|
  Rat   309 PMALY------------ILKDKDSSEPDE-NPATEPRSTTEPGPPGYSVSP 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	3/5 (60%)
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165	19/95 (20%)
		Ig	885..960	CDD:143165	18/74 (24%)
		FN3	967..1051	CDD:238020	19/100 (19%)
Hepacam	XP_038938232.1	Ig	43..141	CDD:416386	22/115 (19%)
		FR1	43..59	CDD:409353	5/27 (19%)
		Ig strand A	43..45	CDD:409353	0/1 (0%)
		Ig strand A'	48..50	CDD:409353	1/1 (100%)
		Ig strand B	53..60	CDD:409353	2/6 (33%)
		CDR1	60..65	CDD:409353	1/4 (25%)
		FR2	66..71	CDD:409353	3/8 (38%)
		Ig strand C	66..70	CDD:409353	2/7 (29%)
		CDR2	72..87	CDD:409353	1/14 (7%)
		Ig strand C'	75..80	CDD:409353	0/4 (0%)
		Ig strand C'	84..87	CDD:409353	1/2 (50%)
		FR3	98..124	CDD:409353	7/27 (26%)
		Ig strand D	98..103	CDD:409353	0/4 (0%)
		Ig strand E	105..109	CDD:409353	2/5 (40%)
		Ig strand F	119..124	CDD:409353	0/4 (0%)
		CDR3	125..133	CDD:409353	1/7 (14%)
		FR4	134..141	CDD:409353	0/6 (0%)
		Ig strand G	134..140	CDD:409353	0/5 (0%)
		Ig	148..236	CDD:416386	24/109 (22%)
		Ig strand A	148..151	CDD:409353	0/2 (0%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	164..170	CDD:409353	2/5 (40%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..188	CDD:409353	2/3 (67%)
		Ig strand D	192..196	CDD:409353	0/3 (0%)
		Ig strand E	199..204	CDD:409353	2/12 (17%)
		Ig strand F	214..222	CDD:409353	3/7 (43%)
		Ig strand G	226..235	CDD:409353	2/8 (25%)
		Herpes_UL1	<324..383	CDD:392246	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910