DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Icam4

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001165548.1	Gene:	Icam4 / 298702	RGDID:	1308971	Length:	264	Species:	Rattus norvegicus

Alignment Length:	271	Identity:	53/271 - (19%)
Similarity:	91/271 - (33%)	Gaps:	108/271 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVL 126
            :.|:|.|:   ..||     |:.:|       ::.|.:|   |..                |.:|
  Rat    64 NCPLPVHS---SLRT-----QLRQG-------KIVNGSG---WVS----------------YQLL 94

  Fly   127 GDRKQGIYNLRISNASINDDADYQCQV---GPARLNSAIRANAKLTVISPPASIEIK-----GYS 183
                    ::|..|:.:      :|.|   |..|     .|.|::|....|.|:.::     |:.
  Rat    95 --------DVRAWNSKV------RCVVTCAGETR-----EATARITAFKRPRSVILEPPVLVGHK 140

  Fly   184 HNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFT------TTSS 242
            :.            |:|.|.:..|...:|     |..:...|  .|...:.:|||      .|.:
  Rat   141 YT------------LRCYVTHVFPVGFLV-----VSLRKGGR--VVYHESLQRFTGSDLANVTLT 186

  Fly   243 LKLKPGPDDDYTEYTCQARHK------------------ALSPDMPMRATVQLSVL----YPPGP 285
            ..::.|.:|.:...||.||..                  ||||.....|::.::.|    ...|.
  Rat   187 YVMRAGLNDLWQPLTCHARLNLDGLVVRSSSAPVMLTVLALSPASISLASISIATLVGIFLAVGA 251

  Fly   286 PYIEGYSAGET 296
            .|:..|.|.:|
  Rat   252 VYVRKYLAVQT 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	17/99 (17%)
		Ig	76..155	CDD:299845	12/81 (15%)
		IG_like	186..279	CDD:214653	23/116 (20%)
		Ig	197..279	CDD:299845	23/105 (22%)
		IG_like	296..376	CDD:214653	1/1 (100%)
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Icam4	NP_001165548.1	ICAM_N	40..123	CDD:252248	21/111 (19%)
Icam4	NP_001165548.1	PHA03271	<124..>167	CDD:223030	10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910