DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Mybpc3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006234565.1	Gene:	Mybpc3 / 295929	RGDID:	1305950	Length:	1276	Species:	Rattus norvegicus

Alignment Length:	1407	Identity:	252/1407 - (17%)
Similarity:	419/1407 - (29%)	Gaps:	529/1407 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGD 128
            |.|.......|...|..::|..|:.|:...|.......|||.:||      :.|....:|.:..:
  Rat     2 PEPGKRPVSAFTKKPRSVEVTAGSAAVFEAETERSGLKVQWQRDG------SDIAANDKYGLAAE 60

  Fly   129 RKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVEVREN 193
            .|:  :.|.:.:...:|...|....|    :|.::.:.|:|..:|
  Rat    61 GKR--HTLTVRDVGPDDQGSYAVIAG----SSKVKFDLKVTEPAP-------------------- 99

  Fly   194 QDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTC 258
                                        |||.|..|..::.:          .|....:......
  Rat   100 ----------------------------PEKAESAVAPTSME----------APETPKEVPALAT 126

  Fly   259 QARHKALSPDMPMRATVQLSVLYPPGPP------YIEGYSAGETLRRGQTVELMCRSRGGN---P 314
            |......||:..:..|...||....|.|      ::.....|| :..|.::....|..|.:   |
  Rat   127 QLEGNVSSPEGSVSVTQDGSVAGSQGAPDDPIGLFLMRPQDGE-VTVGGSIVFSARVAGASLLKP 190

  Fly   315 PAQLIWYKNGSQIRMAYRTSGRL--------SENIYTFTAEAGDNKAR----FRCEAS------- 360
            |. :.|:| |..:.::.:....|        :..:|.|.....|.:|.    :|||.|
  Rat   191 PV-VKWFK-GKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQATSAGGYRCEVSTKDKFDS 253

  Fly   361 ---NVMSQNPL-KAEVELSVLFAPTHVTVMG---------------------------------P 388
               |:.....: ..:::|...|..|.:...|                                 |
  Rat   254 CNFNLTVHEAIGSGDLDLRSAFRRTSLAGTGRRTSDSHEDAGTLDFSSLLKKRDSFRRDSKLEAP 318

  Fly   389 TEARVGDIV------------------------------------------------------PL 399
            .|..|.:|:                                                      .:
  Rat   319 AEEDVWEILRQAPPSEYERIAFQHGVTDLRGMLKRLKGMKHDEKKSTAFQKKLEPAYQVNKGHKI 383

  Fly   400 TCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVI-CHGLNMQ 463
            ..|...::|.||:||:..|::::.:.||.|....|.              ||:|.:. |...:..
  Rat   384 RLTVELADPDAEVKWLKNGQEIQMSGSKYIFESIGA--------------KRTLTISQCSLADDA 434

  Fly   464 LTENVVSTHTINV-LYPPAPP-LISGYMEGQIIPAGSVQKLLC-VSSGGNPLATLTW-------- 517
            ..:.||.....:. |:...|| ||:..:|.|::..|...:..| ||..|   |.:.|
  Rat   435 AYQCVVGGEKCSTELFVKEPPVLITRSLEDQLVMVGQRVEFECEVSEEG---AQVKWLKDGVELT 496

  Fly   518 --------YKNDKR-----INS---------VIRAADKSVSAEITI-------------LANVSD 547
                    :|.|.|     ||.         .:|.:.....||:.:             ||..:.
  Rat   497 REETFKYRFKKDGRKHHLIINEATLEDAGHYAVRTSGGQALAELIVQEKKLEVYQSIADLAVGAK 561

  Fly   548 NQAQYRCEAS----------NSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEA--TIICD 600
            :||.::||.|          |....:|   ...:.|.......|:.|  :::.|..||  :.:.:
  Rat   562 DQAVFKCEVSDENVRGVWLKNGKELVP---DNRIKVSHIGRVHKLTI--DDVTPADEADYSFVPE 621

  Fly   601 SSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRS 665
            ..:.|..|||.:                         :|.::                 :.:.|.
  Rat   622 GFACNLSAKLHF-------------------------MEVKI-----------------DFVPRQ 644

  Fly   666 AHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTT----------- 719
            ....:.||.   |...|   .|.|.|.|..|::.:....:|.| |..|.|..|.
  Rat   645 EPPKIHLDC---PGSTP---DTIVVVAGNKLRLDVPISGDPAP-TVIWQKTITQGKKASAGPPPG 702

  Fly   720 IPQDG--------------------------DHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGG 758
            .|:|.                          |..:|...|:      .::|.|:|:.:..|..|.
  Rat   703 APEDAGADEEWVFDKKLLCETEGRVRVETTKDRSVFTVEGA------EKEDEGVYTVTVKNPVGE 761

  Fly   759 ATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVE--------GKPL--------TEEHVKWE 807
            ..:|:||.|.......:..:  :.|.|||   ||.|:        |:|:        .::..:|.
  Rat   762 DQVNLTVKVIDVPDAPAAPK--ISNVGED---SCIVQWEPPAYDGGQPVLGYILERKKKKSYRWM 821

  Fly   808 RVGYDMTVKTS---TTFANGTSY---------------------------------LHIKDAKRE 836
            |:.:|:..:.|   .....|.:|                                 |.::|....
  Rat   822 RLNFDLLRELSHEARRMIEGVAYEMRVYAVNAVGMSRPSPASQPFMPIGPPGEPTHLTVEDVSDT 886

  Fly   837 DVGNFRCVADNRV------------------------------------DNPTNRDILLIVKF-- 863
            .| :.:.....||                                    |.||...:|..|:.
  Rat   887 TV-SLKWRPPERVGAGGLDGYSVEYCQEGCSEWVTALQGLTERTSLLVKDLPTGARLLFRVRAHN 950

  Fly   864 -----APEIAKTPTLLR-----------------AASGTGERGRLPCRAQGSPKPQFIWRQDKKD 906
                 .|.|.|.|..::                 .....||...|....||.|:||..|.::.:.
  Rat   951 VAGPGGPIITKEPVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQP 1015

  Fly   907 LPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPL 971
            |        ..||..|.:...::.|.:........|.|:...|.|..|...|:.|:|..:|.|||
  Rat  1016 L--------AGEEVSIRNSPTDTILFIRAAHRTHSGTYQVTVRIENMEDKATLVLQIVDKPSPPL 1072

  Fly   972 SLNILNVTHDTVTLAWTPGFDGGLKASYRVRYRMADR---EQYKYIDGLPNSHKLTIGGLRMNTL 1033
            .:.::.....:|.|.|.|..|.|....:....:.||:   |.:..::....:| ..:..|.:...
  Rat  1073 DIRVVETWGFSVALEWKPPQDDGNTEIWGYTVQKADKKTMEWFTVLEHYRQTH-CVVSELIIGNG 1136

  Fly  1034 YLFSVMSWNELGQSSYLPDLARAETKEA----------PPPSHPASSLGGGPPTTSQTPLGGTSG 1088
            |.|.|.|.|.:|.|    |.| |.|||.          .||.:.|......|..|.  ||  |:.
  Rat  1137 YYFRVFSHNMVGSS----DRA-AATKEPIFIPRPGITYEPPKYKALDFSEAPSFTQ--PL--TNR 1192

  Fly  1089 MLLVGVGAGIVVVLLNVFVIGCCLHKRNEKR----LKRGLEL 1126
            .::.|..|           |.||..:.:.|.    .|.||:|
  Rat  1193 SIIAGYNA-----------ILCCAVRGSPKPKISWFKNGLDL 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	20/96 (21%)
		Ig	76..155	CDD:299845	16/78 (21%)
		IG_like	186..279	CDD:214653	10/92 (11%)
		Ig	197..279	CDD:299845	10/81 (12%)
		IG_like	296..376	CDD:214653	19/105 (18%)
		Ig	300..361	CDD:299845	17/85 (20%)
		Ig	380..454	CDD:299845	19/160 (12%)
		IG_like	490..573	CDD:214653	26/136 (19%)
		Ig	501..560	CDD:299845	22/112 (20%)
		Ig	584..666	CDD:299845	10/83 (12%)
		IG_like	585..666	CDD:214653	9/82 (11%)
		I-set	678..767	CDD:254352	26/125 (21%)
		IGc2	692..757	CDD:197706	17/101 (17%)
		Ig	788..849	CDD:143165	14/112 (13%)
		Ig	885..960	CDD:143165	18/74 (24%)
		FN3	967..1051	CDD:238020	22/86 (26%)
Mybpc3	XP_006234565.1	I-set	12..94	CDD:254352	19/93 (20%)
		Ig	<40..92	CDD:299845	13/63 (21%)
		I-set	161..260	CDD:254352	20/101 (20%)
		ig	165..249	CDD:278476	19/86 (22%)
		I-set	367..451	CDD:254352	18/97 (19%)
		IGc2	386..444	CDD:197706	17/71 (24%)
		I-set	458..543	CDD:254352	18/87 (21%)
		IGc2	470..528	CDD:197706	12/60 (20%)
		Ig	565..631	CDD:299845	13/70 (19%)
		Ig_C5_MyBP-C	658..770	CDD:143302	25/121 (21%)
		I-set	658..770	CDD:254352	25/121 (21%)
		FN3	774..864	CDD:238020	15/94 (16%)
		FN3	872..965	CDD:238020	14/93 (15%)
		IG_like	983..1064	CDD:214653	21/88 (24%)
		Ig_Titin_like	992..1064	CDD:143225	19/79 (24%)
		FN3	1068..1151	CDD:238020	22/87 (25%)
		I-set	1183..1272	CDD:254352	15/56 (27%)
		IGc2	1197..1259	CDD:197706	10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000