DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Fcgrt

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_203502.1	Gene:	Fcgrt / 29558	RGDID:	61811	Length:	366	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	54/302 - (17%)
Similarity:	94/302 - (31%)	Gaps:	94/302 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QQHQQHQQQQQQQ--------QQQQHIKWQQHATKRRRCRQHWIKHLQLLR--------LLAVIV 59
            ||:..:...:|:.        :.|....|::..|..:...|.:::.::.|.        |..::.
  Rat    55 QQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLG 119

  Fly    60 LASAPVPSHAQQQKFRTTPHDLQVLEGAEAM-MRCEVANVAGAVQWTKDGFALGFSAVIPGFPRY 123
            ...||..|        :.|..:..|.|.|.| ......|.:|  :|                |..
  Rat   120 CELAPDNS--------SLPTAVFALNGEEFMRFNPRTGNWSG--EW----------------PET 158

  Fly   124 SVLGDRKQGIYNLRISN-ASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSK 187
            .::|       ||.:.. .:...::::.....|.||...:....:......|.|:.:|....||.
  Rat   159 DIVG-------NLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSG 216

  Fly   188 VEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAK-------------RFTT 239
            ..|       |.|...:.              |.||.:...:....|.             .|..
  Rat   217 SSV-------LTCAAFSF--------------YPPELKFRFLRNGLASGSGNCSTGPNGDGSFHA 260

  Fly   240 TSSLKLKPGPDDDYTEYTCQARHKALSP------DMPMRATV 275
            .|.|::|.|   |...|.||..|:.|:.      |.|.|::|
  Rat   261 WSLLEVKRG---DEHHYQCQVEHEGLAQPLTVDLDSPARSSV 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	15/98 (15%)
		Ig	76..155	CDD:299845	12/80 (15%)
		IG_like	186..279	CDD:214653	23/109 (21%)
		Ig	197..279	CDD:299845	21/98 (21%)
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
Fcgrt	NP_203502.1	Alpha-1. /evidence=ECO:0000269\|PubMed:7969498, ECO:0000269\|PubMed:9493268, ECO:0007744\|PDB:1FRT, ECO:0007744\|PDB:3FRU	23..111		8/55 (15%)
		MHC_I	25..198	CDD:395078	27/175 (15%)
		Alpha-2. /evidence=ECO:0000269\|PubMed:7969498, ECO:0000269\|PubMed:9493268, ECO:0007744\|PDB:1FRT, ECO:0007744\|PDB:3FRU	112..201		19/121 (16%)
		IgC1_MHC-like_FcRn	199..291	CDD:409602	23/115 (20%)
		Alpha-3. /evidence=ECO:0000269\|PubMed:7969498, ECO:0000269\|PubMed:9493268, ECO:0007744\|PDB:1FRT, ECO:0007744\|PDB:3FRU	202..291		23/112 (21%)
		Ig strand B	218..222	CDD:409602	2/10 (20%)
		Ig strand C	233..237	CDD:409602	0/3 (0%)
		Ig strand E	262..266	CDD:409602	2/3 (67%)
		Ig strand F	273..278	CDD:409602	2/4 (50%)
		Ig strand G	288..291	CDD:409602	0/2 (0%)
		Connecting peptide	293..298		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910