DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Mag

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_058886.1	Gene:	Mag / 29409	RGDID:	3035	Length:	626	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	136/566 - (24%)
Similarity:	205/566 - (36%)	Gaps:	127/566 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 FQSTTLSVHFAPETVKIR--IEPEELRPGMEATIICDSSSSNPPAK--LSWWKDGIPIEGINNTS 626
            :...|.|.|...:.:...  :.|.|:..|.|..:.|....:.|..:  |||    :..||:   .
  Rat   124 YNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSW----LGHEGL---G 181

  Fly   627 KPGLWG------GT---VSTLEFRVNVTQEMNGQVYTCQSA--NEALQRSAHEAVSLDVLYRPKF 680
            :|.:.|      ||   ||.|.|  ..|:|.||....||:|  |..||...:  .||||.|.|..
  Rat   182 EPTVLGRLREDEGTWVQVSLLHF--VPTREANGHRLGCQAAFPNTTLQFEGY--ASLDVKYPPVI 242

  Fly   681 VPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDA 745
            |...||.. .:||..:.:.....:||.|: ..|.:||..:     ....|:...|:...:...:.
  Rat   243 VEMNSSVE-AIEGSHVSLLCGADSNPPPL-LTWMRDGMVL-----REAVAESLYLDLEEVTPAED 300

  Fly   746 GIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKP---LT---EEHV 804
            |||:|.|.|:.|.....:.:.|.|.....:|:..:|...||...:.|:.:..|   ||   |:.:
  Rat   301 GIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQI 365

  Fly   805 KWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAK 869
                        .:|........|.:.....||.|.:.|||:|:....... ..|.|:|||.|
  Rat   366 ------------LATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATA-FNLSVEFAPII-- 415

  Fly   870 TPTLLRA-ASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYK-YEVEERKIDSLTYESTLI 932
               ||.: .:...:..:..|..:.:|:|...:....:::.:|.|.: :...||....||...||.
  Rat   416 ---LLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLR 477

  Fly   933 VDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPL--------------SLNILNVTHDTV 983
            ....||.   ...|.:||..|    |..||:..|....|              ::.|..|.:.|.
  Rat   478 GQAQAPP---RVICTSRNLYG----TQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQ 535

  Fly   984 T-----LAWTPGFDGGLKASYRVRYRMADREQYKY-----IDGLPNSHKLTIGGLRMNTLYLFSV 1038
            |     :..:|.|..|            |.....|     |.|.|:.::
  Rat   536 TRRKKNVTESPSFSAG------------DNPHVLYSPEFRISGAPDKYE---------------- 572

  Fly  1039 MSWNELGQSSYLPDLARAETKEAPPP---SHPASSLGGGPPTTSQT 1081
             |...||....|..| |.|    ||.   |:..|.||..|...|.|
  Rat   573 -SEKRLGSERRLLGL-RGE----PPELDLSYSHSDLGKRPTKDSYT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	1/6 (17%)
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	29/94 (31%)
		IG_like	585..666	CDD:214653	29/93 (31%)
		I-set	678..767	CDD:254352	21/88 (24%)
		IGc2	692..757	CDD:197706	16/64 (25%)
		Ig	788..849	CDD:143165	14/66 (21%)
		Ig	885..960	CDD:143165	18/75 (24%)
		FN3	967..1051	CDD:238020	16/107 (15%)
Mag	NP_058886.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000269\|PubMed:19420245	20..325		59/218 (27%)
		IgV_CD33	22..138	CDD:409377	3/13 (23%)
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	65..67
		Ig strand E	100..104	CDD:409377
		Ig strand F	114..119	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000250\|UniProtKB:P20917	124..128		0/3 (0%)
		Ig strand G	128..133	CDD:409377	2/4 (50%)
		IgC2_CD33_d2_like	141..235	CDD:409579	30/104 (29%)
		Ig strand B	155..159	CDD:409579	0/3 (0%)
		Ig strand C	171..175	CDD:409579	3/7 (43%)
		Ig strand E	200..204	CDD:409579	2/3 (67%)
		Ig strand F	214..219	CDD:409579	1/4 (25%)
		Ig strand G	229..232	CDD:409579	0/4 (0%)
		Ig_3	239..309	CDD:404760	19/76 (25%)
		Ig strand A	239..242	CDD:409353	1/2 (50%)
		Ig strand A'	248..251	CDD:409353	1/3 (33%)
		Ig strand B	256..264	CDD:409353	0/7 (0%)
		Ig strand C	270..274	CDD:409353	0/4 (0%)
		Ig strand C'	277..280	CDD:409353	1/2 (50%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	5/7 (71%)
		Ig strand G	312..322	CDD:409353	1/9 (11%)
		IG	333..409	CDD:214652	18/88 (20%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000250\|UniProtKB:P20917	577..626		15/41 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..608		11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910