DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and PRTG

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_776175.2 Gene:PRTG / 283659 HGNCID:26373 Length:1150 Species:Homo sapiens


Alignment Length:1106 Identity:225/1106 - (20%)
Similarity:406/1106 - (36%) Gaps:268/1106 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   585 EPEELRPGMEATIICD-SSSSNPPAKLSWWKDGIP------IEGINNTSKPGLWGGTVSTLEFRV 642
            ||:::....:..::.| .:....|.|::|.|:|..      ||.::|.|   |:   :|.:|.|.
Human    44 EPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSNGS---LY---ISEVEGRR 102

  Fly   643 NVTQEMNGQVYTCQSANE---ALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRA 704
            .  ::.:...|.|.:.|:   .|.:.||.|:|.    ...|...|.||.|. ||...:.:.:..:
Human   103 G--EQSDEGFYQCLAMNKYGAILSQKAHLALST----ISAFEVQPISTEVH-EGGVARFACKISS 160

  Fly   705 NPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSA---SNSQGGATLNITVV 766
            :| |....|..:.||:|...|.......|.|....:.:.|:|.|.|.|   ::.:.....::||:
Human   161 HP-PAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVI 224

  Fly   767 VE------YGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGT 825
            ..      :..||.:..:||..:..:..:|.|...|.|  :..:.|.|:.: .::....|...|.
Human   225 PAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP--KPIISWSRLDH-KSIDVFNTRVLGN 286

  Fly   826 SYLHIKDAKREDVGNFRCVADNRVDNPTNRDI-----LLIVKFAPEIAKTP-TLLRAASGTGERG 884
            ..|.|.|.:.:..|.:.|    |...|..|:.     .|.|...|...:.| :|.|..:||   .
Human   287 GNLMISDVRLQHAGVYVC----RATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGT---A 344

  Fly   885 RLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVAR 949
            |..|:|:|.|.|:..|.::.:.:..|...|           .|.|.|:::::.|.|...|:|:|.
Human   345 RFVCQAEGIPSPKMSWLKNGRKIHSNGRIK-----------MYNSKLVINQIIPEDDAIYQCMAE 398

  Fly   950 NELGEAVETVRLEIT---SQPDPPLSLNILNVTHDTVTLAW-TPGFDGGLKASYRVRYRMAD--- 1007
            |..|..:...||.:.   .:|..|.:::...::...:.||| .|.::.....:|.|.|..|:   
Human   399 NSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLN 463

  Fly  1008 REQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLG 1072
            .|:|:.:.|...:|.: |..|...:.|.|.::::..:| :|.:.|.....|.|..|...|..|| 
Human   464 NEEYQVVIGNDTTHYI-IDDLEPASNYTFYIVAYMPMG-ASQMSDHVTQNTLEDVPLRPPEISL- 525

  Fly  1073 GGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRG---LELMPAELTED 1134
                 ||::|             ..|::..|.:           ..:.:||   |..:...|:.:
Human   526 -----TSRSP-------------TDILISWLPI-----------PAKYRRGQVVLYRLSFRLSTE 561

  Fly  1135 SS--------NTPNLVIIGISLAAFGFLLVNASL-------VAWFFVHQRRK-------KVAETT 1177
            :|        .|...::.|:...:...:.:.|:.       ..| ..|:..|       |..|..
Human   562 NSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVW-TSHRTPKATSVKAPKSPELH 625

  Fly  1178 NQPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQ--PEYIDEVRKKAASTYLVEGS 1240
            .:|....||.:.......||      :::......|..||..:  |.::|    .....|.:.|.
Human   626 LEPLNCTTISVRWQQDVEDT------AAIQGYKLYYKEEGQQENGPIFLD----TKDLLYTLSGL 680

  Fly  1241 DMPPPRYQKDGTLPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPD 1305
            | |..:|.    :.::..||:.:...........|..::.    |:|:           |.|||.
Human   681 D-PRRKYH----VRLLAYNNIDDGYQADQTVSTPGCVSVR----DRMV-----------PPPPPP 725

  Fly  1306 GSYY---NMNSDRYLSYPPMEYPAA--LDFTAQPMPM---------------AH-----LQPMT- 1344
            ...|   |.:|..:|.:....:.||  :::|.:..|:               .|     |:|.| 
Human   726 HHLYAKANTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTK 790

  Fly  1345 --------VTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILR---GVVGVPQPD-----VTHHT- 1392
                    |..|::...|.:..:....|.||....::..::.   .:|....||     ||.:| 
Human   791 YEFAVRLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIEDDTALVSWKPPDGPETVVTRYTI 855

  Fly  1393 ------STVGGSPMQMLH----------------DLHPVNLSASTLTTSTTLNGSLPTATATLPR 1435
                  :.:.|. .|:||                :::.|.:|||........:.|:  ..|.||:
Human   856 LYASRKAWIAGE-WQVLHREGAITMALLENLVAGNVYIVKISASNEVGEGPFSNSV--ELAVLPK 917

  Fly  1436 QPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQIL--------- 1491
            :    ..:.|:..::......:.........|:.:....||||:.::..|..:.||         
Human   918 E----TSESNQRPKRLDSADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKS 978

  Fly  1492 -----------NLPPASGGL--GNNLLMTTNAFDPTTVGLSSFGAVSQAGGI-----PVAYTDAD 1538
                       .||..|..|  ||.            ||.:..|||.....:     |.::.||.
Human   979 SASKTAQNGTQQLPRTSASLASGNE------------VGKNLEGAVGNEESLMPMIMPNSFIDAK 1031

  Fly  1539 G 1539
            |
Human  1032 G 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653
Ig 197..279 CDD:299845
IG_like 296..376 CDD:214653
Ig 300..361 CDD:299845
Ig 380..454 CDD:299845
IG_like 490..573 CDD:214653
Ig 501..560 CDD:299845
Ig 584..666 CDD:299845 20/90 (22%)
IG_like 585..666 CDD:214653 20/90 (22%)
I-set 678..767 CDD:254352 23/91 (25%)
IGc2 692..757 CDD:197706 16/67 (24%)
Ig 788..849 CDD:143165 13/60 (22%)
Ig 885..960 CDD:143165 19/74 (26%)
FN3 967..1051 CDD:238020 20/87 (23%)
PRTGNP_776175.2 Ig 40..130 CDD:299845 22/93 (24%)
Ig 139..223 CDD:299845 20/85 (24%)
IG_like 141..223 CDD:214653 20/83 (24%)
IG_like 241..323 CDD:214653 19/88 (22%)
IGc2 250..309 CDD:197706 14/65 (22%)
I-set 327..412 CDD:254352 27/98 (28%)
Ig 345..412 CDD:299845 21/77 (27%)
FN3 419..512 CDD:238020 21/94 (22%)
FN3 517..610 CDD:238020 19/123 (15%)
fn3 624..699 CDD:278470 17/89 (19%)
FN3 726..814 CDD:238020 15/87 (17%)
FN3 821..911 CDD:238020 16/92 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 981..1002 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1086..1150
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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