DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Robo2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006523098.1	Gene:	Robo2 / 268902	MGIID:	1890110	Length:	1598	Species:	Mus musculus

Alignment Length:	1218	Identity:	265/1218 - (21%)
Similarity:	418/1218 - (34%)	Gaps:	324/1218 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 PPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKS---------VSA 537
            ||.|..:....|:..|....|.| .:.|.|..|:.|||:.:|:.:     ||.         .|.
Mouse    53 PPRIVEHPSDVIVSKGEPTTLNC-KAEGRPTPTIEWYKDGERVET-----DKDDPRSHRMLLPSG 111

  Fly   538 EITILANV-----SDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE--LRPGMEA 595
            .:..|..|     ..::..|.|.|.|...|.   .|...|:..|......|..|.:  :..|..|
Mouse   112 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEA---VSRNASLEVALLRDDFRQNPTDVVVAAGEPA 173

  Fly   596 TIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANE 660
            .:.|.....:|...:.|.||.:.|:  :...:..:.||     :..::.|::.:..:|||...|.
Mouse   174 ILECQPPRGHPEPTIYWKKDKVRID--DKEERISIRGG-----KLMISNTRKSDAGMYTCVGTNM 231

  Fly   661 ALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGD 725
            ..:|.:..| .|.|..||.|:..|.:..| :|.|:::...|.:.:|.| |.:|.||...:|: |.
Mouse   232 VGERDSDPA-ELTVFERPTFLRRPINQVV-LEEEAVEFRCQVQGDPQP-TVRWKKDDADLPR-GR 292

  Fly   726 HRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVS-ENIVVNP----- 784
            :.| .|..:|...:....|.|.|.|.|.|..|....:.|:.|.    ::.|: ...||.|
Mouse   293 YDI-KDDYTLRIKKAMSTDEGTYVCIAENRVGKVEASATLTVR----VRPVAPPQFVVRPRDQIV 352

  Fly   785 --GEDAMLSCTVEGKPLTEEHVKWERVGYDMTV-------KTSTTFANGTSYLHIKDAKREDVGN 840
              |......|..:|.|  :..|.|::.|....:       ..|....:.|..|.|.:.:|.|.|.
Mouse   353 AQGRTVTFPCETKGNP--QPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGY 415

  Fly   841 FRC----------------VADNRVDNPTNRDILLIVKFAPEIAKTP---TLLRAASGTGERGRL 886
            :.|                |.|...|.|           .|.|.:.|   ||  |..||   ..|
Mouse   416 YICQALTVAGSILAKAQLEVTDVLTDRP-----------PPIILQGPINQTL--AVDGT---ALL 464

  Fly   887 PCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNE 951
            .|:|.|.|.|...|.::.... :.|..:..:::        :.||.:..:..:|.|.|.|||.:.
Mouse   465 KCKATGEPLPVISWLKEGFTF-LGRDPRATIQD--------QGTLQIKNLRISDTGTYTCVATSS 520

  Fly   952 LGEAVETVRLEITSQ-------------PDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRV-- 1001
            .||...:..|::|..             |.||....:.:|:.::|||:|.||..|.|.||..:
Mouse   521 SGETSWSAVLDVTESGATISKNYDMNDLPGPPSKPQVTDVSKNSVTLSWQPGTPGVLPASAYIIE 585

  Fly  1002 RYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKEAPPPSH 1066
            .:..:....::.:.....:...|:.|||.||:|||.|.:.|..|.|...|......|::..||:.
Mouse   586 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQ 650

  Fly  1067 PA------SSLGG------GP----PTTSQTP---------LGG-------TSGMLLVGVGAGI- 1098
            ..      ..||.      .|    |||.|..         :.|       |||:....|...:
Mouse   651 GVDHRQVQKELGDVVVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQASTVWQNLD 715

  Fly  1099 -------VVVLLNVFVIGCCLHKRNEKRLKRGL------------------ELMPAELTEDSSNT 1138
                   ..||:|               ||:|:                  |......||::.:.
Mouse   716 AKVPTERSAVLVN---------------LKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 765

  Fly  1139 PNLVIIGISLAAFGFLLVNAS---------------LVAWFFVHQRRKKVAETTNQPAKTATIEM 1188
            |...:..:::.:.....::.|               ...|...::.|..:.:|.:...::..|..
Mouse   766 PPQSVTVLTVGSHNSTSISVSWDPPPADHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVVIGG 830

  Fly  1189 YAPS-SYNDTVTGETLSSVSEKSES------------YSNEGSSQPEYIDEVRKKAASTYLVEGS 1240
            ..|. .|...|...|.:.|..|||.            .:...:|..|.|.:|.|:.|   .:.|
Mouse   831 LFPGIQYRVEVAASTSAGVGVKSEPQPIIIGGRNEVVITENNNSITEQITDVVKQPA---FIAG- 891

  Fly  1241 DMPPPRYQKDGTLPVIYPNNVVNACTL------------PHPRHNNGSAAIHMTRDDQMLISKGV 1293
                                :..||.:            ...|....:.|:...|.|..|:|.|.
Mouse   892 --------------------IGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGS 936

  Fly  1294 YIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALD-FTAQPMPMAHLQPMTVTSLATNGGPTLI 1357
            . |....|..|:                  ||...| :.|..:|:.:          :|.||..|
Mouse   937 R-PGLLNAGDPN------------------YPWLADSWPATSLPVNN----------SNSGPNEI 972

  Fly  1358 GNGSVAAVAGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTL 1422
            ||..                ||.|..|.|.....|:|       ||.|  ....|:...||.||.
Mouse   973 GNFG----------------RGDVLPPVPGQGDKTAT-------MLSD--GAIYSSIDFTTKTTY 1012

  Fly  1423 NGSLPTATATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAP--- 1484
            |.|.....||    |:...:..:.|...:........|.:...||:   ..|:|.|  .|.|
Mouse  1013 NSSSQITQAT----PYATTQILHSNSIHELAVDLPDPQWKSSVQQK---TDLMGFG--YSLPDQN 1068

  Fly  1485 LGSLQILNLPP--ASGGLGNNLLMT-TNAFDPTTVGLSSFGAVSQAGG 1529
            .|:..:|.:|.  .:.||.|.:... :..|..|:...||..:.|.:||
Mouse  1069 KGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSGG 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	22/96 (23%)
		Ig	501..560	CDD:299845	18/72 (25%)
		Ig	584..666	CDD:299845	17/83 (20%)
		IG_like	585..666	CDD:214653	17/82 (21%)
		I-set	678..767	CDD:254352	26/88 (30%)
		IGc2	692..757	CDD:197706	20/64 (31%)
		Ig	788..849	CDD:143165	16/83 (19%)
		Ig	885..960	CDD:143165	18/74 (24%)
		FN3	967..1051	CDD:238020	27/85 (32%)
Robo2	XP_006523098.1	Ig1_Robo	53..152	CDD:143317	26/107 (24%)
		Ig	160..244	CDD:386229	19/91 (21%)
		Ig	265..333	CDD:386229	20/70 (29%)
		Ig4_Robo	355..444	CDD:143203	19/101 (19%)
		IG	451..532	CDD:214652	25/94 (27%)
		FN3	549..642	CDD:238020	28/92 (30%)
		FN3	673..758	CDD:238020	16/99 (16%)
		FN3	767..859	CDD:238020	13/91 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910