DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and NECTIN3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_011510965.1	Gene:	NECTIN3 / 25945	HGNCID:	17664	Length:	580	Species:	Homo sapiens

Alignment Length:	393	Identity:	95/393 - (24%)
Similarity:	149/393 - (37%)	Gaps:	79/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PHDLQVLEGAEAMMRC--EVANVAGAVQWTKDGFALGFSA--VIPGFPRYSVLGDRKQGIYNLRI 138
            || :..:.|....::|  ||......:.|.|   ..|.|:  |....|:|   |...||.|..|:
Human    95 PH-VTAVWGKNVSLKCLIEVNETITQISWEK---IHGKSSQTVAVHHPQY---GFSVQGEYQGRV 152

  Fly   139 --SNASIN------------DDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKGYSHNSKVE 189
              .|.|:|            |...|.|:.....|.:| :::..:||:..|....|||  .:|.::
Human   153 LFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNA-QSSTTVTVLVEPTVSLIKG--PDSLID 214

  Fly   190 VRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYT 254
             ..|:.:...||.|..||.|.|.| .|::    .:.|.|......:..|..|..||.|.......
Human   215 -GGNETVAAICIAATGKPVAHIDW-EGDL----GEMESTTTSFPNETATIISQYKLFPTRFARGR 273

  Fly   255 EYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETL-RRGQTVELMCRSRGGNPPAQL 318
            ..||..:|.||..|  :|.:..|.:.|.| ...:.||.....: |:|  |.|.|.:....||.:.
Human   274 RITCVVKHPALEKD--IRYSFILDIQYAP-EVSVTGYDGNWFVGRKG--VNLKCNADANPPPFKS 333

  Fly   319 IWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARF------------RCEASNVMSQNPLKAE 371
            :|          .|..|:..:.:.     |.||...|            .|:.:|.:.|   :::
Human   334 VW----------SRLDGQWPDGLL-----ASDNTLHFVHPLTFNYSGVYICKVTNSLGQ---RSD 380

  Fly   372 VELSVLFAPTHVTVMGPT---EARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIV-SP 432
            .::..:..|...|.:.||   .....||..|  .|.|...|..:..:.   .:::.|..||: |.
Human   381 QKVIYISDPPTTTTLQPTIQWHPSTADIEDL--ATEPKKLPFPLSTLA---TIKDDTIATIIASV 440

  Fly   433 EGG 435
            .||
Human   441 VGG 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	26/109 (24%)
		Ig	76..155	CDD:299845	24/94 (26%)
		IG_like	186..279	CDD:214653	26/92 (28%)
		Ig	197..279	CDD:299845	24/81 (30%)
		IG_like	296..376	CDD:214653	17/92 (18%)
		Ig	300..361	CDD:299845	14/72 (19%)
		Ig	380..454	CDD:299845	16/60 (27%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
NECTIN3	XP_011510965.1	IG_like	95..197	CDD:214653	26/109 (24%)
		Ig1_Nectin-3_like	103..198	CDD:143295	24/101 (24%)
		Ig	201..296	CDD:299845	30/104 (29%)
		IG_like	318..379	CDD:214653	15/78 (19%)
		Ig_3	<318..373	CDD:290638	13/69 (19%)
		TM_EGFR-like	435..463	CDD:213052	5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910