DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Il1rap

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_038943965.1	Gene:	Il1rap / 25466	RGDID:	2893	Length:	697	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	128/677 - (18%)
Similarity:	203/677 - (29%)	Gaps:	252/677 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 SSGGNPLATLTWY--KNDKRINSVI--RAADKSVSAEITIL---ANVSDNQAQYRCEASNSATEI 563
            |||    .||.||  :.|:.:...|  |..:..:|.|..:|   ..:.::...|.|
  Rat    75 SSG----LTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTC--------- 126

  Fly   564 PLFQSTTL--SVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPI------E 620
             :.::||.  .|.|..|.|:                  ..|..|.|.:|       |:      :
  Rat   127 -MLRNTTYCSKVAFPLEVVQ------------------KDSCFNSPMRL-------PVHRLYIEQ 165

  Fly   621 GINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPS 685
            ||:|.:.|.:.|                                           |.|..|.|
  Rat   166 GIHNITCPNVDG-------------------------------------------YFPSSVKP-- 185

  Fly   686 STAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSC 750
                                    :..|.|..|.|.  ..|.:...|.:|:|......:.|.|:|
  Rat   186 ------------------------SVTWYKGCTEIV--NFHNVQPKGMNLSFFIPLVSNNGNYTC 224

  Fly   751 SASNSQGGATLNIT---VVVEYGTT-------IKSVSENIVV--NPGEDAMLSCTVEGKPLTEEH 803
            ..:..:.|...::|   .|...|:.       |.|.::.:|.  .|||:.::.|.|....:.:.|
  Rat   225 VVTYLENGRLFHLTRTMTVKVVGSPKDAVPPHIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSH 289

  Fly   804 --VKW-------ERVGYDMTVKTSTTFAN-----GTSYLHIKDAKREDV-GNFRCVADNRVDN-- 851
              :.|       :.|..|:|:..|.::::     .|..|.||....||: .|:.|.|.|....
  Rat   290 NEIWWTIDGKKPDDVPVDITINESVSYSSTEDETRTQILSIKKVTPEDLKRNYVCHARNAEGEAE 354

  Fly   852 ----------PTNRDILLIVKFAPEIAKTPTLL--------------RAASGTGERGRLPCRAQG 892
                      |....:.|...|...:.....|:              ||..||.|.
  Rat   355 QAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDET--------- 410

  Fly   893 SPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECV-ARNEL--GE 954
                    ..|.|:..|..:|....||.:...||....|      ..::|...|: .|:.|  |.
  Rat   411 --------ILDGKEYDIYVSYARNAEEEEFVLLTLRGVL------ENEFGYKLCIFDRDSLPGGN 461

  Fly   955 AVETV--------RLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYR-------VRYR 1004
            .||.|        |:.:...||        .||..::::.   .|..|:.....       |.||
  Rat   462 TVEAVFDFIQRSRRMIVVLSPD--------YVTEKSISML---EFKLGVMCQNSIATKLIVVEYR 515

  Fly  1005 ---------MADREQYKYID--GLPNSH------KLTIGGLRMNTLYLFSVMSWNELGQSS---Y 1049
                     |..:|...::.  |..:.|      |.....|.:.:|...|  .|||...|.   .
  Rat   516 PLEQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALPLRSLSASS--GWNESCSSQSDIS 578

  Fly  1050 LPDLARAETKEAPPPSHPASSLGGGPP 1076
            |..:.|....:.||....:..:.|..|
  Rat   579 LDHVQRRSRLKEPPELQSSERVSGAAP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	17/75 (23%)
		Ig	501..560	CDD:299845	15/60 (25%)
		Ig	584..666	CDD:299845	10/87 (11%)
		IG_like	585..666	CDD:214653	10/86 (12%)
		I-set	678..767	CDD:254352	16/91 (18%)
		IGc2	692..757	CDD:197706	11/64 (17%)
		Ig	788..849	CDD:143165	18/75 (24%)
		Ig	885..960	CDD:143165	17/85 (20%)
		FN3	967..1051	CDD:238020	21/110 (19%)
Il1rap	XP_038943965.1	Ig1_IL1R_like	37..144	CDD:409584	20/82 (24%)
		Ig strand B	55..59	CDD:409584
		Ig strand C	79..83	CDD:409584	2/3 (67%)
		Ig strand E	109..113	CDD:409584	1/3 (33%)
		Ig strand F	123..128	CDD:409584	2/14 (14%)
		Ig strand G	136..139	CDD:409584	1/2 (50%)
		Ig	155..247	CDD:416386	25/169 (15%)
		Ig strand A	157..162	CDD:409353	1/4 (25%)
		Ig strand A	157..162	CDD:409353	1/4 (25%)
		Ig strand B	168..172	CDD:409353	1/3 (33%)
		Ig strand B	168..172	CDD:409353	1/3 (33%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C	186..191	CDD:409353	1/4 (25%)
		Ig strand C'	194..196	CDD:409353	1/1 (100%)
		Ig strand C'	194..196	CDD:409353	1/1 (100%)
		Ig strand D	201..205	CDD:409353	0/3 (0%)
		Ig strand D	201..205	CDD:409353	0/3 (0%)
		Ig strand E	207..212	CDD:409353	1/4 (25%)
		Ig strand E	207..212	CDD:409353	1/4 (25%)
		Ig strand F	221..230	CDD:409353	2/8 (25%)
		Ig strand F	221..230	CDD:409353	2/8 (25%)
		Ig strand G	233..246	CDD:409353	2/12 (17%)
		Ig strand G	233..246	CDD:409353	2/12 (17%)
		Ig3_IL1RAP	255..361	CDD:409525	24/105 (23%)
		Ig strand B	274..278	CDD:409525	0/3 (0%)
		Ig strand C	291..295	CDD:409525	0/3 (0%)
		Ig strand E	326..330	CDD:409525	1/3 (33%)
		Ig strand F	341..346	CDD:409525	2/4 (50%)
		Ig strand G	353..356	CDD:409525	0/2 (0%)
		TIR	416..559	CDD:214587	31/159 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910