DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and Kirrel2

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_766486.1 Gene:Kirrel2 / 243911 MGIID:2442334 Length:700 Species:Mus musculus


Alignment Length:741 Identity:185/741 - (24%)
Similarity:275/741 - (37%) Gaps:142/741 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 VLASAPV------PSHA-QQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAV 116
            :||||.:      ..|| ....|...|.|:.||.|.||.:.|.:....|.|||||||.|||....
Mouse     1 MLASALLVFLCCFKGHAGSSPHFLQQPEDMVVLLGEEARLPCALGAYRGLVQWTKDGLALGGERD 65

  Fly   117 IPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPASIEIKG 181
            :||:.||.:.|:...|.::|.|....:.|:|.|:||...|.|.|   ..|:|.|:.||.:.::.|
Mouse    66 LPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRS---RPAQLHVMVPPEAPQVLG 127

  Fly   182 YSHNSKVEVRENQDLQLKC-IVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKL 245
               ...|.:.......|.| ...:::||.:::|:|..:.........|..:..|.. |..::|.|
Mouse   128 ---GPSVSLVAGVPGNLTCRSRGDSRPAPELLWFRDGIRLDGSSFHQTTLKDKATG-TVENTLFL 188

  Fly   246 KPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSR 310
            .|...||.....|:||.:||.....  ..|.||:.|   ||.:...:..:|::.|:.|..:|::.
Mouse   189 TPSSHDDGATLICRARSQALPTGRD--TAVTLSLQY---PPMVTLSAEPQTVQEGEKVTFLCQAT 248

  Fly   311 GGNPPAQLIWYKNGSQIRMAYRTSGRLSENI--YTFTAEAGDNKARFRCEASN-VMSQNPLKAEV 372
            ...|.....|.|.||.:..|   .|...|.:  .||..|.      ..||.|| |.|.|...|  
Mouse   249 AQPPVTGYRWAKGGSPVLGA---RGPRLEVVADATFLTEP------VSCEVSNAVGSANRSTA-- 302

  Fly   373 ELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKW-MVGGRQVRNATSKTIVSPEGGW 436
             |.||:.|............||.....:|... .||...|.| .:||.||. ::..|:..|....
Mouse   303 -LEVLYGPILQAKPKSVSVDVGKDASFSCVWR-GNPLPRITWTRMGGSQVL-SSGPTLRLPSVAL 364

  Fly   437 TTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQK 501
            ....:.....||.:..|    .|...|....|.:...:..| .|||..:.|       ||    :
Mouse   365 EDAGDYVCRAEPRRTGL----GGGKAQARLTVNAPPVVTAL-QPAPAFLRG-------PA----R 413

  Fly   502 LLCV--SSGGNPLATLTWYKNDKRINSVIRAADKSVSAE----------ITIL----ANVSDNQA 550
            |.||  :|........:|.:......|:.|...::..|.          |::|    ...||...
Mouse   414 LQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFTT 478

  Fly   551 QYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPP-------A 608
            .:.|.|.|...|               ..|:|.:...:|.|.:.  |:..::|:...       .
Mouse   479 GFNCSARNRLGE---------------GRVQIHLGRRDLLPTVR--IVAGAASAATSLLMVITGV 526

  Fly   609 KLSWWKDGIPIEGINNTSKPGLWGGTVST-LEFRVNVTQEMNGQVYTCQS-----ANEALQ---- 663
            .|..|:.|...:..|....||...|:.|. .|.....:::....|:|..|     ..|||:    
Mouse   527 VLCCWRHGSLSKQKNLVRIPGSSEGSSSRGPEEETGSSEDRGPIVHTDHSDLVLEEKEALETKDP 591

  Fly   664 -----RSAHEAVSLDVLYRP---KFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTI 720
                 |....:|||.:...|   .|:||||  .:|:.|             ||..|.:......:
Mouse   592 TNGYYRVRGVSVSLSLGEAPGGGLFLPPPS--PIGLPG-------------TPTYYDFKPHLDLV 641

  Fly   721 PQDGDHRIFADGGSLNFTRLHRDDAG 746
            |.               .||:|..||
Mouse   642 PP---------------CRLYRARAG 652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352 38/96 (40%)
Ig 76..155 CDD:299845 32/78 (41%)
IG_like 186..279 CDD:214653 22/93 (24%)
Ig 197..279 CDD:299845 21/82 (26%)
IG_like 296..376 CDD:214653 24/82 (29%)
Ig 300..361 CDD:299845 16/62 (26%)
Ig 380..454 CDD:299845 16/74 (22%)
IG_like 490..573 CDD:214653 18/98 (18%)
Ig 501..560 CDD:299845 15/74 (20%)
Ig 584..666 CDD:299845 20/103 (19%)
IG_like 585..666 CDD:214653 20/102 (20%)
I-set 678..767 CDD:254352 17/72 (24%)
IGc2 692..757 CDD:197706 10/55 (18%)
Ig 788..849 CDD:143165
Ig 885..960 CDD:143165
FN3 967..1051 CDD:238020
Kirrel2NP_766486.1 IG 27..116 CDD:214652 37/91 (41%)
Ig 122..220 CDD:416386 23/103 (22%)
Ig strand A 123..126 CDD:409353 0/2 (0%)
Ig strand A' 129..133 CDD:409353 1/3 (33%)
Ig strand B 140..147 CDD:409353 2/6 (33%)
Cell attachment site. /evidence=ECO:0000255 146..148 0/1 (0%)
Ig strand C 153..158 CDD:409353 0/4 (0%)
Ig strand C' 161..163 CDD:409353 0/1 (0%)
Ig strand D 166..173 CDD:409353 0/6 (0%)
Ig strand E 180..188 CDD:409353 2/8 (25%)
Ig strand F 197..205 CDD:409353 2/7 (29%)
Ig strand G 211..217 CDD:409353 0/7 (0%)
Ig_3 223..292 CDD:404760 19/77 (25%)
Ig strand B 241..245 CDD:409353 1/3 (33%)
Ig strand C 255..259 CDD:409353 0/3 (0%)
Ig strand E 272..275 CDD:409353 0/2 (0%)
Ig strand F 281..290 CDD:409353 3/14 (21%)
Ig strand G 298..301 CDD:409353 1/2 (50%)
Ig 315..392 CDD:416386 18/82 (22%)
Ig strand A' 316..321 CDD:409353 0/4 (0%)
Ig strand B 324..333 CDD:409353 1/8 (13%)
Ig strand C 339..343 CDD:409353 1/3 (33%)
Ig strand C' 346..348 CDD:409353 1/1 (100%)
Ig strand D 351..354 CDD:409353 0/3 (0%)
Ig strand E 355..360 CDD:409353 1/4 (25%)
Ig strand F 368..376 CDD:409353 0/7 (0%)
Ig strand G 382..392 CDD:409353 2/9 (22%)
Ig 394..498 CDD:416386 25/130 (19%)
Ig strand A 395..399 CDD:409353 0/3 (0%)
Ig strand A' 401..404 CDD:409353 1/3 (33%)
Ig strand B 412..419 CDD:409353 4/10 (40%)
Ig strand C 426..431 CDD:409353 0/4 (0%)
Ig strand C' 433..436 CDD:409353 0/2 (0%)
Ig strand D 444..451 CDD:409353 0/6 (0%)
Ig strand E 461..468 CDD:409353 2/6 (33%)
Ig strand F 479..486 CDD:409353 2/6 (33%)
Ig strand G 489..496 CDD:409353 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..576 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 671..700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141865at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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