DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Myom3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001078978.1	Gene:	Myom3 / 242702	MGIID:	2685280	Length:	1439	Species:	Mus musculus

Alignment Length:	1097	Identity:	210/1097 - (19%)
Similarity:	345/1097 - (31%)	Gaps:	360/1097 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 PPAS--IEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKRED-------- 227
            |.||  :::....|..:.|.:|.:...|:     ...:.|...||.:.|.:....||
Mouse    13 PQASQTVQVHRLEHRQEEEQKEERQHSLQ-----MGSSVQRRTYRSSEEEQQFSSEDYALAAALA 72

  Fly   228 -TVE-----ESTAKRFTTTSSLKLKP------GPDDDYTEYTCQARHKALSPDMPMRATVQLSVL 280
             |..     |:..:|.|||..|:.:.      |.|.:..|.......:.|......:|..|
Mouse    73 LTASSELSWEAKLRRQTTTVELEERGQRRVGFGNDLERMELAFLRTQRLLRQRRDWKALRQ---- 133

  Fly   281 YPPGPPYIEGYSAGETLRRGQTVELMCRSRG-------------------------GNPPAQLIW 320
                       ...|.:|..:.:..:|..||                         |:||.|:.|
Mouse   134 -----------RTEEKVREAKELIELCSGRGPWFWIPLRSHAVWEHTTVLLTCTVQGSPPFQVTW 187

  Fly   321 YKNGSQIRMAYRTSG--RLSENIYTFTAEAGDNKARFRC-----------------EASN---VM 363
            |||..:|......:|  |::.|....|.|.      .||                 :||:   |:
Mouse   188 YKNDIRIDPRLFPAGKYRITNNYGLLTLEI------MRCTVEDSATYTVLVKNAYGQASSFAKVL 246

  Fly   364 SQNPL------KAEVELSVLFAPT--HVTVMGPTEARVGDIVPLTCTTAPSNPPAE--IKWMVGG 418
            .:|.|      .:|:....:|.|:  ..:|:.|..|:..:...|||..:.....||  |:|...|
Mouse   247 IRNYLGKDAGFDSEIFKRSMFGPSAEFTSVLKPIFAQEKEPFSLTCLFSDDVLEAEQRIQWYRDG 311

  Fly   419 RQVRNATSKTIV---------------SPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQ----- 463
            |.:|::|.:.|:               ..||.:|.  .:::...|.::|..|.......:
Mouse   312 RLLRSSTRRQILYADRQASVKVSCAYKEDEGFYTI--RVSSPFGPQEQSAYVFIRDAAAEKPGAP 374

  Fly   464 ---LTENVVSTHTINVLYPPAPP------LISGYMEGQIIPAGSVQKLLCVSSGGN----PLATL 515
               |....::.|...:.....||      .|:|| ..::....|.:.:.|:.:.|.    |:..|
Mouse   375 GSPLNVRCLNVHRDCLTLTWVPPSDTRGSTITGY-SIEMCQGDSEEWMPCLKAPGGTCRCPIQGL 438

  Fly   516 TWYKNDK-RINSVIRAA----DKSVSAEITILANVSDNQAQYRCEASNSATEIP--LFQSTTLSV 573
            ...::.: |:.::.:|.    .|:..|.:|         ..|  :|.:.:||||  |....|:|.
Mouse   439 VEGQSYQFRVRAISKAGTSLPSKASEAVVT---------GDY--DAVHKSTEIPYDLGSKITISK 492

  Fly   574 HFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWW----KDGIPIEGINNTSKPGLWGGT 634
            :...:.|.|...|         |.:..|......|.|||.    :...|:  .....|..:..||
Mouse   493 NDFEDAVTIPSAP---------TNVHASEIREAYAVLSWEEPRPRGRAPL--TYTLEKSVIGSGT 546

  Fly   635 ---------VSTLEFRVNVTQEMNGQVYTCQSANE-ALQRSAHEAVSLDVLYRPKFVPPPSSTAV 689
                     :.:..|.:...::....|:..::.|: .:...:..:..:.:..:|..:|||:....
Mouse   547 WEAISTETPIKSPRFALLDLEKGKSYVFRVRALNQYGMSDPSEPSEPVALKGKPATLPPPAQVQA 611

  Fly   690 GVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASN 754
                        .|...|.|:..|.      |.||       |..|....::..:||.......|
Mouse   612 ------------FRNTQTSVSLAWE------PVDG-------GSELLGYYIYSREAGASEWQTVN 651

  Fly   755 SQGGATLNITVV-----VEYGTTIKSVSENIVVN-------------------PGEDAMLSCTVE 795
            ::.......||.     .||...|:||||..|..                   |.:.|:|:|
Mouse   652 NKPIQDTKFTVPGLRTGKEYDFCIRSVSEAGVGESSAATQPVRVKQALATPSAPYDFALLNC--- 713

  Fly   796 GKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVD------NPTN 854
            ||  .|..:.|                        |..||...|.......::.|      :|.|
Mouse   714 GK--NEMVIGW------------------------KPPKRRGGGKILGYFMDQHDSVESDWHPVN 752

  Fly   855 RDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEE 919
            |                                     .|.|..:.    |...::..:.||...
Mouse   753 R-------------------------------------QPIPSRVC----KVTNLHEGHFYEFRA 776

  Fly   920 RKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVT 984
            |.::..                |..|..|.:.|.|..|....|    |.||..:.:..|...:|.
Mouse   777 RAVNWA----------------GIGELSAPSSLFECKEWTMPE----PGPPYDVRVSEVQATSVM 821

  Fly   985 LAWTPG--FDGGLKASYRVRYRMADREQYKYI--DGLPNSHKLTIGGLRMNTLYLFSVMSWNE-- 1043
            |.|.|.  ...|....|.|.::....|::|.:  |...::| |.:..|:....|:|.|.:.|.
Mouse   822 LQWEPPLYIGAGPVTGYHVSFQEKGSEEWKPVTPDATSDTH-LRVSDLQPGKQYMFRVQAMNSAG 885

  Fly  1044 LGQSSYLPDLARAETK--------------------EAP-PPSHPA---SSLGGGPP 1076
            |||.|...|....|.|                    ||| .|..|.   |....|||
Mouse   886 LGQPSVPTDPVLLEDKPDAQEIEVGVDDEGQIYLAFEAPEAPDFPEFQWSKDYQGPP 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	22/112 (20%)
		Ig	197..279	CDD:299845	20/101 (20%)
		IG_like	296..376	CDD:214653	26/132 (20%)
		Ig	300..361	CDD:299845	20/104 (19%)
		Ig	380..454	CDD:299845	21/92 (23%)
		IG_like	490..573	CDD:214653	18/93 (19%)
		Ig	501..560	CDD:299845	11/67 (16%)
		Ig	584..666	CDD:299845	14/95 (15%)
		IG_like	585..666	CDD:214653	14/94 (15%)
		I-set	678..767	CDD:254352	18/93 (19%)
		IGc2	692..757	CDD:197706	12/64 (19%)
		Ig	788..849	CDD:143165	11/60 (18%)
		Ig	885..960	CDD:143165	12/74 (16%)
		FN3	967..1051	CDD:238020	25/89 (28%)
Myom3	NP_001078978.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		10/48 (21%)
		I-set	154..247	CDD:254352	19/98 (19%)
		Ig	171..244	CDD:143165	18/78 (23%)
		I-set	272..363	CDD:254352	21/92 (23%)
		Ig	289..360	CDD:143165	17/72 (24%)
		FN3	374..467	CDD:238020	16/93 (17%)
		FN3	502..592	CDD:238020	14/100 (14%)
		FN3	604..691	CDD:238020	25/111 (23%)
		FN3	702..792	CDD:238020	25/175 (14%)
		FN3	804..893	CDD:238020	25/89 (28%)
		IG_like	1137..1207	CDD:214653
		Ig	1138..1200	CDD:143165
		Ig	1336..1426	CDD:299845
		I-set	1343..1426	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000