DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and NFASC

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_024310051.1	Gene:	NFASC / 23114	HGNCID:	29866	Length:	1513	Species:	Homo sapiens

Alignment Length:	1495	Identity:	291/1495 - (19%)
Similarity:	472/1495 - (31%)	Gaps:	527/1495 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 DMPMRATVQLSVLYPPGPPYIEGYSAGETL---RRGQTVELMCRSRGGNPPAQLIWYKNGSQIRM 329
            ::||..::|..:..   ||.|...||.:.:   |....:|  |.:: |||.....|.:|.....:
Human   175 EIPMDPSIQNELTQ---PPTITKQSAKDHIVDPRDNILIE--CEAK-GNPAPSFHWTRNSRFFNI 233

  Fly   330 A-----------------YRTSGRLSENIYTFTAEAGDNKARFRCEASNVMS---QNPLKAEVEL 374
            |                 :|:.||..|           .:..::|.|.|...   .|.::.:|..
Human   234 AKDPRVSMRRRSGTLVIDFRSGGRPEE-----------YEGEYQCFARNKFGTALSNRIRLQVSK 287

  Fly   375 SVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTT 439
            |.|:...:   :.|...:.|..:.|.|...|..|...|.||....: .....|.:.....|....
Human   288 SPLWPKEN---LDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSME-PITQDKRVSQGHNGDLYF 348

  Fly   440 SNIT------------------AVVEPNKRSLVVIC-HGLNMQLTEN--------VVSTHTINVL 477
            ||:.                  .:.:.|..:|.|:. |..|.....|        .|:..|.:.:
Human   349 SNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARGVAERTPSFM 413

  Fly   478 YPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYK------NDK----RINSVIRAAD 532
            ||      .|....|::..|....|.|::| |.|...:.|||      :||    ..|..:|
Human   414 YP------QGTASSQMVLRGMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALR--- 468

  Fly   533 KSVSAEITILANVS-DNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRI--------EPEE 588
                     :.||| ::..:|.|.|||....|             ..|:.:|:        ||:.
Human   469 ---------ITNVSEEDSGEYFCLASNKMGSI-------------RHTISVRVKAAPYWLDEPKN 511

  Fly   589 --LRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQ 651
              |.||.:..::| .::.||...:.|..:|.|::.........:.|.|:.   ||  .||..:..
Human   512 LILAPGEDGRLVC-RANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTII---FR--DTQISSRA 570

  Fly   652 VYTCQSANEALQRSAHEAVS-LDVLYRPKFVPPPSSTAVGVEGESLQVSLQTR--------ANPT 707
            ||.|.::||.....|:..|| |||  .|:.:.|        ..:.::|.|..|        .:|.
Human   571 VYQCNTSNEHGYLLANAFVSVLDV--PPRMLSP--------RNQLIRVILYNRTRLDCPFFGSPI 625

  Fly   708 PVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTT 772
            | |.:|.|:|.....||.:....:.|||....:.::|.|||:|.|:|..|.|...:.:.|:..|.
Human   626 P-TLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTR 689

  Fly   773 IKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKRED 837
            |..:.|:.|...|....|.|.|:..|..:..|.|                       :||.:...
Human   690 IYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSW-----------------------LKDDEPLY 731

  Fly   838 VGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQ 902
            :||                                                            |.
Human   732 IGN------------------------------------------------------------RM 736

  Fly   903 DKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNEL-------------GE 954
            .|:|                ||||      :..||..|.|:|.|||..||             .:
Human   737 KKED----------------DSLT------IFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQ 779

  Fly   955 AVETVRLEI--TSQPDPPLSLNILNVTHDTVTLAWTPG-FDGGLKASYRVRYRMADREQYKYIDG 1016
            |..|.||..  ..:||.|..|.:.::...:|.|.|.|| .:......|.|::     |:.::..|
Human   780 ATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQF-----EEDQFQPG 839

  Fly  1017 LPNSHKLTIGGLRMNTL-------YLFSVMSWNELGQSSYLPDL--ARAETKEAPPPSHPASSLG 1072
            :.:.|....|.:....|       |.|.|::.||:|.|.  |.|  .|..|..|||.|:|....|
Human   840 VWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSH--PSLPSERYRTSGAPPESNPGDVKG 902

  Fly  1073 GGPPTTSQ----TPLGGTSGMLLVGVGAGI-----------------VVVLLNVFVIGCCLHKRN 1116
            .|....:.    ||:..||..     |..:                 |.|..:.:|:|
Human   903 EGTRKNNMEITWTPMNATSAF-----GPNLRYIVKWRRRETREAWNNVTVWGSRYVVG------- 955

  Fly  1117 EKRLKRGLELMPAELTEDSSNTPNLVIIGISLAA---FGFLLVNASLVAWFFVHQRRKKVAETTN 1178
                                .||..|...|.:.|   ||......|::.:......|....|...
Human   956 --------------------QTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKV 1000

  Fly  1179 QPAKTATIEMYAPSSYNDTVTGETLSSVSEKSESYSNEGSSQPE-YIDEVRKKAA---------- 1232
            :...:..|.:.....|:|||.|:    :.|....|..|.|.... ::.:.|::|:
Human  1001 RVMNSTAISLQWNRVYSDTVQGQ----LREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVV 1061

  Fly  1233 ------STY-----LVEGSDMPPPRYQKDGTLP-----------VIYPNNVVNACTLPHPRHNNG 1275
                  |.|     :|.|....|....|:.|.|           |..||.........||.|.||
Human  1062 SRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNG 1126

  Fly  1276 --------SAAIHMTRDDQML-------------------------------ISKGVYIPSPSPA 1301
                    ..|.:.|:..:.:                               :..|..:...|||
Human  1127 IMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPA 1191

  Fly  1302 PPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQPMTVTSLATNGGPTLIG-NGSVAAV 1365
            ||.:.:             |...|..|.                        ||.:| .|:|::.
Human  1192 PPNEAT-------------PTAAPPTLP------------------------PTTVGATGAVSST 1219

  Fly  1366 AGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNL-SASTLTTSTTLNGSLPTA 1429
                                 |.|...:|...:.:.::..:.|..: :.:|:.|:||...:..|.
Human  1220 ---------------------DATAIAATTEATTVPIIPTVAPTTIATTTTVATTTTTTAAATTT 1263

  Fly  1430 TATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGV----------------- 1477
            |.:.|....|           .:..:....:|.:.:...|.|:....:
Human  1264 TESPPTTTSG-----------TKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYI 1317

  Fly  1478 -------GVPVSAPLGSLQILNLPPA-----------SGGLGNNLL--MTTNAFDPTTVGLSSFG 1522
                   .|||.|....:|:.:|.|.           :.|:.:.::  ||:.|:......:::.|
Human  1318 DSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQG 1382

Fly 1523 1522
Human 1383 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	3/10 (30%)
		Ig	197..279	CDD:299845	3/10 (30%)
		IG_like	296..376	CDD:214653	18/102 (18%)
		Ig	300..361	CDD:299845	14/77 (18%)
		Ig	380..454	CDD:299845	14/91 (15%)
		IG_like	490..573	CDD:214653	23/93 (25%)
		Ig	501..560	CDD:299845	20/69 (29%)
		Ig	584..666	CDD:299845	22/91 (24%)
		IG_like	585..666	CDD:214653	22/82 (27%)
		I-set	678..767	CDD:254352	25/96 (26%)
		IGc2	692..757	CDD:197706	21/72 (29%)
		Ig	788..849	CDD:143165	10/60 (17%)
		Ig	885..960	CDD:143165	19/87 (22%)
		FN3	967..1051	CDD:238020	23/91 (25%)
NFASC	XP_024310051.1	Ig_hNeurofascin_like	208..284	CDD:143283	16/89 (18%)
		Ig	289..381	CDD:325142	15/95 (16%)
		Ig3_L1-CAM_like	430..500	CDD:319298	23/95 (24%)
		Ig	517..592	CDD:325142	21/80 (26%)
		Ig	615..681	CDD:319273	20/66 (30%)
		I-set	694..775	CDD:254352	30/185 (16%)
		FN3	794..884	CDD:238020	25/96 (26%)
		FN3	895..985	CDD:238020	21/121 (17%)
		FN3	994..1093	CDD:238020	19/102 (19%)
		FN3	1098..1189	CDD:238020	11/90 (12%)
		fn3	1287..1359	CDD:306538	10/71 (14%)
		Bravo_FIGEY	1405..1489	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910