DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and F830045P16Rik

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_808321.1	Gene:	F830045P16Rik / 228592	MGIID:	3045317	Length:	487	Species:	Mus musculus

Alignment Length:	443	Identity:	99/443 - (22%)
Similarity:	155/443 - (34%)	Gaps:	111/443 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 WYRGNVEYKPEKREDTVEEST------AKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPM 271
            |.|.|.|: |......|..:.      :|.:.|.:.       .|..::.||:..|..|..  |:
Mouse    70 WLRNNNEH-PASTTHVVHVNNDSYSLRSKAWVTLTK-------QDISSQITCEVTHGDLKE--PL 124

  Fly   272 RATVQLSVLYPPGP--------PYIEGYSAGETLRRGQTVELMCRSRGGNPP-AQLIWYKNGSQI 327
            |.|:.||.:....|        |.|:.:.       .|.|.|.|......|. ..|||.|||.:|
Mouse   125 RMTINLSQVLRVIPTLKITTEDPEIQDHV-------HQKVNLTCHVNHFYPQNMDLIWTKNGHKI 182

  Fly   328 -RMAYRTSGRLSENIY----TFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMG 387
             .|....:.|.|:..|    |...:|..||..|.|.... ..|.|:|..:.|.   ||.  .:.|
Mouse   183 PTMELPQTTRNSDGTYSLQHTLQVDAILNKTDFVCWVIQ-DDQPPVKNSITLG---APR--KIRG 241

  Fly   388 PTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRS 452
            .||.......||  ...|.....::|:.....|.|..|...:.:......|.:|:.:..|
Mouse   242 RTEYSHHLEGPL--QRFPPGASIQLKYTSSALQTRQVTVTWLKNNHTRLQTQTNVFSNGE----- 299

  Fly   453 LVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYME-------------GQII---PAGSVQK 501
                        |.||.||..:::.......|:...:|             ||.:   ||..|.:
Mouse   300 ------------TYNVTSTAIVSLESDDILSLVLCLVEHKSLVVFQKVIYLGQYLCVPPAVRVSQ 352

  Fly   502 LLCVSSGGNPLATLT-----WYKNDKRIN-----SVIRAADKSVSAEITILANVSDNQAQYRCEA 556
            ...|||    |.|:|     :|..:..::     .|||..::.....        :....|..|
Mouse   353 SSTVSS----LVTVTCHVQRFYPQEVYLSWLEDCHVIRRIEQPTPKR--------NEDGSYTLE- 404

  Fly   557 SNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAK 609
                    :.|....||..:.:.:..::|.|| .|.::|:|:. |::|.|.:|
Mouse   405 --------VLQLVNTSVERSDQVLTCKVEHEE-HPPIQASIVL-SAASFPTSK 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	17/71 (24%)
		Ig	197..279	CDD:299845	17/71 (24%)
		IG_like	296..376	CDD:214653	26/85 (31%)
		Ig	300..361	CDD:299845	22/66 (33%)
		Ig	380..454	CDD:299845	14/73 (19%)
		IG_like	490..573	CDD:214653	19/108 (18%)
		Ig	501..560	CDD:299845	12/68 (18%)
		Ig	584..666	CDD:299845	10/26 (38%)
		IG_like	585..666	CDD:214653	10/25 (40%)
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
F830045P16Rik	NP_808321.1	Ig	34..138	CDD:299845	18/77 (23%)
		IgC	147..219	CDD:143166	24/78 (31%)
		Ig	251..346	CDD:299845	19/113 (17%)
		IgC	348..436	CDD:143166	21/109 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910