DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and Iglon5

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001157990.1	Gene:	Iglon5 / 210094	MGIID:	2686277	Length:	336	Species:	Mus musculus

Alignment Length:	328	Identity:	83/328 - (25%)
Similarity:	130/328 - (39%)	Gaps:	58/328 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 PSSTAVGVEGESLQVSL-----QTRA---NPTPVTY----KWTKDG-----TTIPQDGDHRIFAD 731
            |:......||::..:|.     .||.   |.:.:.|    :||.|.     ...|::
Mouse    38 PADNYTVCEGDNATLSCFIDEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEE-------- 94

  Fly   732 GGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEG 796
             .|:..|::...|.|:|:||........|..:.::|.....|.::|..:.||.|.:..|.|...|
Mouse    95 -FSILITQVGLGDEGLYTCSFQTRHQPYTTQVYLIVHVPARIVNISSPVAVNEGGNVNLLCLAVG 158

  Fly   797 KPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDN-PTNRDILLI 860
            :|  |..|.|.::        ...|.:....|.|.|.:|...|.:.||..|.|:: |.:|.:|:.
Mouse   159 RP--EPTVTWRQL--------RDGFTSEGEILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVT 213

  Fly   861 VKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSL 925
            |.:.|.|....:   |.:..|....|.|.|...|...|.|.:|.:.|...     ..|..|:.:.
Mouse   214 VNYPPTITDVTS---ARTALGRAALLRCEAMAVPPADFQWYKDDRLLSSG-----SAEGLKVQTE 270

  Fly   926 TYESTLIVDKVAPADYGAYECVARNELGEAVETVR------LEITSQPDPPLSLNILNVTHDTVT 984
            ...|.|:...|:...||.|.|.|.|.||.:..::|      || .|.|.||..|.:|:      .
Mouse   271 RTRSMLLFANVSARHYGNYTCRAANRLGASSASMRLLRPGSLE-NSAPRPPGPLTLLS------A 328

  Fly   985 LAW 987
            |:|
Mouse   329 LSW 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	20/99 (20%)
		IGc2	692..757	CDD:197706	18/81 (22%)
		Ig	788..849	CDD:143165	16/60 (27%)
		Ig	885..960	CDD:143165	21/74 (28%)
		FN3	967..1051	CDD:238020	7/21 (33%)
Iglon5	NP_001157990.1	Ig	41..129	CDD:416386	19/96 (20%)
		Ig strand A'	41..46	CDD:409353	0/4 (0%)
		Ig strand B	48..56	CDD:409353	1/7 (14%)
		CDR1	56..60	CDD:409353	0/3 (0%)
		FR2	61..68	CDD:409353	2/6 (33%)
		Ig strand C	61..67	CDD:409353	2/5 (40%)
		CDR2	69..79	CDD:409353	1/9 (11%)
		Ig strand C'	71..74	CDD:409353	0/2 (0%)
		Ig strand C'	76..79	CDD:409353	0/2 (0%)
		FR3	80..115	CDD:409353	10/43 (23%)
		Ig strand D	84..91	CDD:409353	0/6 (0%)
		Ig strand E	94..100	CDD:409353	1/14 (7%)
		Ig strand F	107..115	CDD:409353	4/7 (57%)
		CDR3	116..120	CDD:409353	0/3 (0%)
		Ig strand G	120..129	CDD:409353	1/8 (13%)
		FR4	122..129	CDD:409353	1/6 (17%)
		Ig strand A	132..137	CDD:409353	1/4 (25%)
		Ig_3	134..199	CDD:404760	20/74 (27%)
		Ig strand A'	140..145	CDD:409353	0/4 (0%)
		Ig strand B	148..157	CDD:409353	2/8 (25%)
		Ig strand C	163..167	CDD:409353	1/3 (33%)
		Ig strand D	174..177	CDD:409353	0/2 (0%)
		Ig strand E	178..183	CDD:409353	1/4 (25%)
		Ig strand F	191..199	CDD:409353	3/7 (43%)
		Ig_3	217..295	CDD:404760	22/85 (26%)
		putative Ig strand A	218..224	CDD:409353	2/5 (40%)
		Ig strand B	234..238	CDD:409353	1/3 (33%)
		Ig strand C	247..251	CDD:409353	1/3 (33%)
		Ig strand E	274..278	CDD:409353	2/3 (67%)
		Ig strand F	288..293	CDD:409353	2/4 (50%)
		Ig strand G	301..304	CDD:409353	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910