DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and CADM4

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_660339.1 Gene:CADM4 / 199731 HGNCID:30825 Length:388 Species:Homo sapiens


Alignment Length:301 Identity:87/301 - (28%)
Similarity:136/301 - (45%) Gaps:42/301 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   547 DNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLS 611
            :::..|.|:.   .||....|..||:|..|||...:.:. |:...|.|..:.|....|.|.|.|.
Human    97 EDEGGYFCQL---YTEDTHHQIATLTV
LVAPENPVVEVR-EQAVEGGEVELSCLVPRSRPAATLR 157

  Fly   612 WWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVS---LD 673
            |::|...::|::::.:.|......||:.|||:  ::.:|.:..|::.|:||. |.|...:   ||
Human   158 WYRDRKELKGVSSSQENGKVWSVASTVRFRVD--RKDDGGIIICEAQNQALP-SGHSKQTQYVLD 219

  Fly   674 VLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFT 738
            |.|.|. ....:|.||..||::|.::.....||.|...:|.:...::|:    |..|.|.:|...
Human   220 VQYSPT-ARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPE----RAEAVGETLTLP 279

  Fly   739 RLHRDDAGIYSCSASNSQGGA-TLNITVVVEYGTTIK---SVSENIV-------------VNPGE 786
            .|...|.|.|:|.|||..|.| .|.:.||.:.|..::   ||...||             |..| 
Human   280 GLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVG- 343

  Fly   787 DAMLSCTV--EGKPLTEEHVKWERVGYDMTVKTSTTFANGT 825
              |:.|:|  :|..||.     |..|.|...:....|.||:
Human   344 --MVWCSVRQKGSYLTH-----EASGLDEQGEAREAFLNGS 377

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653
Ig 197..279 CDD:299845
IG_like 296..376 CDD:214653
Ig 300..361 CDD:299845
Ig 380..454 CDD:299845
IG_like 490..573 CDD:214653 7/25 (28%)
Ig 501..560 CDD:299845 2/12 (17%)
Ig 584..666 CDD:299845 22/81 (27%)
IG_like 585..666 CDD:214653 22/80 (28%)
I-set 678..767 CDD:254352 28/89 (31%)
IGc2 692..757 CDD:197706 20/64 (31%)
Ig 788..849 CDD:143165 12/40 (30%)
Ig 885..960 CDD:143165
FN3 967..1051 CDD:238020
CADM4NP_660339.1 Ig 29..120 CDD:416386 7/25 (28%)
FR1 29..45 CDD:409353
Ig strand A' 30..36 CDD:409353
Ig strand B 38..46 CDD:409353
CDR1 46..51 CDD:409353
FR2 52..59 CDD:409353
Ig strand C 52..58 CDD:409353
CDR2 60..71 CDD:409353
Ig strand C' 62..66 CDD:409353
Ig strand C' 68..71 CDD:409353
FR3 72..107 CDD:409353 2/12 (17%)
Ig strand D 76..83 CDD:409353
Ig strand E 86..92 CDD:409353
Ig strand F 99..107 CDD:409353 2/10 (20%)
CDR3 108..111 CDD:409353 2/2 (100%)
Ig strand G 111..120 CDD:409353 3/8 (38%)
FR4 113..120 CDD:409353 3/6 (50%)
IgI_2_Necl-4 121..220 CDD:409468 28/102 (27%)
Ig strand B 141..145 CDD:409468 0/3 (0%)
Ig strand C 155..159 CDD:409468 1/3 (33%)
Ig strand E 182..186 CDD:409468 2/3 (67%)
Ig strand F 196..201 CDD:409468 1/4 (25%)
Ig strand G 213..216 CDD:409468 0/2 (0%)
Ig_3 224..295 CDD:404760 22/75 (29%)
Ig strand A' 231..235 CDD:409353 2/3 (67%)
Ig strand B 241..248 CDD:409353 1/6 (17%)
Ig strand C 255..260 CDD:409353 1/4 (25%)
Ig strand C' 262..264 CDD:409353 0/1 (0%)
Ig strand E 274..280 CDD:409353 1/5 (20%)
Ig strand F 287..294 CDD:409353 3/6 (50%)
Ig strand G 300..308 CDD:409353 2/7 (29%)
4.1m 344..362 CDD:128590 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11787
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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