DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Robo3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_006510170.1	Gene:	Robo3 / 19649	MGIID:	1343102	Length:	1403	Species:	Mus musculus

Alignment Length:	1340	Identity:	268/1340 - (20%)
Similarity:	438/1340 - (32%)	Gaps:	459/1340 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 LYPPAPPLISGYMEGQIIPAGSVQKL------LCVSSG----------GNPLATLTWYKNDKRIN 525
            |.||..|.::|...|   |..::.::      |.||.|          |.|...:.||||..|
Mouse    44 LLPPGDPSLNGSRVG---PEDAMPRIVEQPPDLVVSRGEPATLPCRAEGRPRPNIEWYKNGAR-- 103

  Fly   526 SVIRAADKSVSAEITILANVS-------------DNQAQYRCEASN----SATEIPLFQSTTLSV 573
              :..|.:...|...:|.:.:             .::..|.|.|.|    :|:.....:...|..
Mouse   104 --VATAREDPRAHRLLLPSGALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRD 166

  Fly   574 HF--APETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVS 636
            .|  :|..|.:.:       |..|.:.|.....:|...::|.|..|.::  ....:..:.||
Mouse   167 DFRQSPGNVVVAV-------GEPAVMECVPPKGHPEPLVTWKKGKIKLK--EEEGRITIRGG--- 219

  Fly   637 TLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQ 701
              :..::.|.:.:..:|.|.::|.|.:|.: .|..|.||.||.|:..|.:..| :....:....:
Mouse   220 --KLMMSHTFKSDAGMYMCVASNMAGERES-GAAELVVLERPSFLRRPINQVV-LADAPVNFLCE 280

  Fly   702 TRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVV 766
            .:.:|.| ...|.||...:|. |.:.|.:| .||...::..:|.|.|:|.|.||.|.|..:.::.
Mouse   281 VQGDPQP-NLHWRKDDGELPA-GRYEIRSD-HSLWIDQVSSEDEGTYTCVAENSVGRAEASGSLS 342

  Fly   767 VEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTT-------FANG 824
            |.......:..:|..|.||.:....|..:|.|  ...:.|::.|..:.:..|.:       ..:.
Mouse   343 VHVPPQFVTKPQNQTVAPGANVSFQCETKGNP--PPAIFWQKEGSQVLLFPSQSLQPMGRLLVSP 405

  Fly   825 TSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASG----TGERGR 885
            ...|:|.:.|..|.|.:.|.|.: |........||.:|.|......|.:|:..:.    .|....
Mouse   406 RGQLNITEVKIGDGGYYVCQAVS-VAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVW 469

  Fly   886 LPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARN 950
            ||||..|:|:|...|::|::.|        :.::.:. :|....||.:..:...|.|.|.|||::
Mouse   470 LPCRVIGNPQPNIQWKKDERWL--------QGDDSQF-NLMDNGTLHIASIQEMDMGFYSCVAKS 525

  Fly   951 ELGEAVETVRLE--------------ITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKA-SYR 1000
            .:|||.....|.              .::.|.||....:..||.:::||.|.|....|..| ||.
Mouse   526 SIGEATWNSWLRKQEDWGASPGPATGPSNPPGPPSQPIVTEVTANSITLTWKPNPQSGATATSYV 590

  Fly  1001 VR-YRMADREQYKYI-DGLPNSHKLTIGGLRMNTLYLFSV------------------------- 1038
            :. :..|....::.: ||: .....||.||:.||:|||.|
Mouse   591 IEAFSQAAGNTWRTVADGV-QLETYTISGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVQTQADSS 654

  Fly  1039 --------------------------------------------------MSWNELG-------- 1045
                                                              :||...|
Mouse   655 LSRPAEDPWKGQRGLAEVAVRMQEPTVLGPRTLQVSWTVDGPVQLVQGFRVSWRIAGLDQGSWTM 719

  Fly  1046 --------QSSYL-------------------------PDLARAETKEAP--PPSHPASSLGGG- 1074
                    ||:.|                         |.:.|:..:|||  ||...|.:|||.
Mouse   720 LDLQSPHKQSTVLRGLPPGAQIQIKVQVQGQEGLGAESPFVTRSIPEEAPSGPPQGVAVALGGDR 784

  Fly  1075 ---------PPTTSQTP----------LGGT------------------SGML-------LV--- 1092
                     ||..||..          ||..                  ||:|       ||
Mouse   785 NSSVTVSWEPPLPSQRNGVITEYQIWCLGNESRFHLNRSAAGWARSVTFSGLLPGQIYRALVAAA 849

  Fly  1093 ---GVGAGIVVVLLNV---------------------------------------FVIGCC--LH 1113
               |||.....||:.:                                       .::|.|  |:
Mouse   850 TSAGVGVASAPVLVQLPFPPAAEPGPEVSEGLAERLAKVLRKPAFLAGSSAACGALLLGFCAALY 914

  Fly  1114 KRNEKRLK-----RGLELMPA-------ELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFV 1166
            :|.::|.:     ......||       .|:..||..|    :|:..||:.:|       |..:.
Mouse   915 RRQKQRKELSHYTASFAYTPAVSFPHSEGLSGSSSRPP----MGLGPAAYPWL-------ADSWP 968

  Fly  1167 HQRRKKVAETTNQPA---------------KTATIEMY-APSSYNDTVTGE-----TLSSVSEKS 1210
            |..|...|:   :|.               ..|.|.:| |.::.....:||     |:..|.|:.
Mouse   969 HPPRSPSAQ---EPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGANASGEGPVYSTIDPVGEEL 1030

  Fly  1211 ES----YSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQK--------DGTL---PVIYP-- 1258
            ::    :....|..|           ||:    |...||.:.:        .|.|   ||..|
Mouse  1031 QTFHGGFPQHSSGDP-----------STW----SQYAPPEWSEGDSGARGGQGKLLGKPVQMPSL 1080

  Fly  1259 ----------------------------NNVVNAC-TLPHPRHNNGSAAIHMTRDDQMLISKGVY 1294
                                        :::...| .:|...|..||:            |.|..
Mouse  1081 SWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPVPEKSHLVGSS------------SSGAC 1133

  Fly  1295 IPSPSP--APPPDGSYYNMNSDRYLS-------YPPMEYPAALDFTAQPMPMAHLQPMTVTSLAT 1350
            :.:|:|  .|.|..| |...|...|:       .||.:.| .|....:.:|:....|::|:..|.
Mouse  1134 MVAPAPRDTPSPTSS-YGQQSTATLTPSPPDPPQPPTDIP-HLHQMPRRVPLGPSSPLSVSQPAL 1196

  Fly  1351 ---NGGPTLIGNGSVAAV------AGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLH-- 1404
               :|.|..:|.|.|.:.      ...:.:...|..|.|.|...|.:..|.:.:...|..:.:
Mouse  1197 SSHDGRPVGLGAGPVLSYHASPSPVPSTASSAPGRTRQVTGEMTPPLHGHRARIRKKPKALPYRR 1261

  Fly  1405 -----DLHPVNLSASTLTTSTTLNGSLPTATATLPRQPHG 1439
                 ||.|..|......||..|......:.::|.|:..|
Mouse  1262 EHSPGDLPPPPLPPPEEETSWPLGLRAAGSMSSLERERSG 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	22/115 (19%)
		Ig	501..560	CDD:299845	18/91 (20%)
		Ig	584..666	CDD:299845	15/81 (19%)
		IG_like	585..666	CDD:214653	15/80 (19%)
		I-set	678..767	CDD:254352	24/88 (27%)
		IGc2	692..757	CDD:197706	18/64 (28%)
		Ig	788..849	CDD:143165	13/67 (19%)
		Ig	885..960	CDD:143165	22/74 (30%)
		FN3	967..1051	CDD:238020	32/202 (16%)
Robo3	XP_006510170.1	Ig	64..162	CDD:386229	19/101 (19%)
		Ig	170..254	CDD:386229	19/98 (19%)
		Ig	275..343	CDD:386229	20/70 (29%)
		Ig4_Robo	361..450	CDD:143203	19/91 (21%)
		Ig	451..531	CDD:386229	24/88 (27%)
		FN3	564..649	CDD:238020	23/85 (27%)
		FN3	678..761	CDD:238020	7/82 (9%)
		FN3	771..864	CDD:238020	22/92 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910