DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and sax-3

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:NP_001024990.1 Gene:sax-3 / 180637 WormBaseID:WBGene00004729 Length:1273 Species:Caenorhabditis elegans


Alignment Length:660 Identity:162/660 - (24%)
Similarity:254/660 - (38%) Gaps:113/660 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   468 VVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNP-LATLTWYK-------NDKRI 524
            |:..|.|:|                ::..||...|.|   |..| .|.:||||       |.:::
 Worm    32 VIIEHPIDV----------------VVSRGSPATLNC---GAKPSTAKITWYKDGQPVITNKEQV 77

  Fly   525 NS--VIRAADKSVSAEITILANVSDNQA-QYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEP 586
            ||  ::.........::....|..|:.| .|.|.|||...|:   :|...|:..|......|:.|
 Worm    78 NSHRIVLDTGSLFLLKVNSGKNGKDSDAGAYYCVASNEHGEV---KSNEGSLKLAMLREDFRVRP 139

  Fly   587 EELRP--GMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLW--GGTVSTLEFRVNVTQE 647
            ..::.  |..|.:.|......|...:||.||...:. |.:..:..|.  |..:      ::....
 Worm   140 RTVQALGGEMAVLECSPPRGFPEPVVSWRKDDKELR-IQDMPRYTLHSDGNLI------IDPVDR 197

  Fly   648 MNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTP-VTY 711
            .:...|.|.:.|...:|.::.| .|.|..:|||...|....|.| |.::....:...:|.| :| 
 Worm   198 SDSGTYQCVANNMVGERVSNPA-RLSVFEKPKFEQEPKDMTVDV-GAAVLFDCRVTGDPQPQIT- 259

  Fly   712 KWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSV 776
             |.:....:|....: |..|...|...|:...|.|.|.|.|.|..|....:..:.|:...:.::.
 Worm   260 -WKRKNEPMPVTRAY-IAKDNRGLRIERVQPSDEGEYVCYARNPAGTLEASAHLRVQAPPSFQTK 322

  Fly   777 SENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANG------TSYLHIKDAKR 835
            ..:..|..|..|...||:.|:|  .....|.:.|....:..|...|:|      |..|.|::.::
 Worm   323 PADQSVPAGGTATFECTLVGQP--SPAYFWSKEGQQDLLFPSYVSADGRTKVSPTGTLTIEEVRQ 385

  Fly   836 EDVGNFRCVADNRVDNPTNRDILLIVKFA-----PEIAKTP----------TLLRAASGTGERGR 885
            .|.|.:.|...|...:..::..|.:...|     |  ||.|          ||:     .|....
 Worm   386 VDEGAYVCAGMNSAGSSLSKAALKVTTKAVTGNTP--AKPPPTIEHGHQNQTLM-----VGSSAI 443

  Fly   886 LPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARN 950
            |||:|.|.|.|...|.:|  .|||      ::.:.:|...:..|..|.|...| |.|.|.|:|:|
 Worm   444 LPCQASGKPTPGISWLRD--GLPI------DITDSRISQHSTGSLHIADLKKP-DTGVYTCIAKN 499

  Fly   951 ELGEAV---------ETVRLEITSQPDP------PLSLNILNVTHDTVTLAW-TPGFDG-GLKAS 998
            |.||:.         .|...:....|||      |....|:|||...|.|.| .|...| |....
 Worm   500 EDGESTWSASLTVEDHTSNAQFVRMPDPSNFPSSPTQPIIVNVTDTEVELHWNAPSTSGAGPITG 564

  Fly   999 YRVRYRMADREQYKYIDGLPN---SHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKE 1060
            |.::|...|..|..:  .:|:   |.:..|.||:.:..|:|.:.:.||.|..:  |.::.|....
 Worm   565 YIIQYYSPDLGQTWF--NIPDYVASTEYRIKGLKPSHSYMFVIRAENEKGIGT--PSVSSALVTT 625

  Fly  1061 APPPSHPASS 1070
            :.|.:..|.|
 Worm   626 SKPAAQVALS 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653
Ig 197..279 CDD:299845
IG_like 296..376 CDD:214653
Ig 300..361 CDD:299845
Ig 380..454 CDD:299845
IG_like 490..573 CDD:214653 24/93 (26%)
Ig 501..560 CDD:299845 20/69 (29%)
Ig 584..666 CDD:299845 16/85 (19%)
IG_like 585..666 CDD:214653 16/84 (19%)
I-set 678..767 CDD:254352 23/89 (26%)
IGc2 692..757 CDD:197706 16/65 (25%)
Ig 788..849 CDD:143165 17/66 (26%)
Ig 885..960 CDD:143165 27/83 (33%)
FN3 967..1051 CDD:238020 28/94 (30%)
sax-3NP_001024990.1 Ig 30..129 CDD:299845 29/118 (25%)
I-set 31..121 CDD:254352 27/110 (25%)
I-set 135..223 CDD:254352 19/95 (20%)
Ig2_Robo 137..223 CDD:143201 18/93 (19%)
I-set 227..313 CDD:254352 23/89 (26%)
Ig 244..313 CDD:299845 16/71 (23%)
I-set 317..410 CDD:254352 20/94 (21%)
Ig 331..411 CDD:299845 19/81 (23%)
Ig 424..512 CDD:299845 30/101 (30%)
I-set 432..512 CDD:254352 29/93 (31%)
FN3 531..624 CDD:238020 27/96 (28%)
FN3 659..747 CDD:238020
FN3 755..836 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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